Reactome | PTK6 Regulates Proteins Involved in RNA Processing

PTK6 Regulates Proteins Involved in RNA Processing

Stable Identifier

R-HSA-8849468

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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PTK6 Regulates Proteins Involved in RNA Processing

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PTK6 binds and phosphorylates several nuclear RNA-binding proteins, including SAM68 family members (KHDRSB1, KHDRSB2 and KHDRSB3) (Derry et al. 2000, Haegebarth et al. 2004, Lukong et al. 2005) and SFPQ (PSF) (Lukong et al. 2009). The biological role of PTK6 in RNA processing is not known.

Literature References

PubMed ID	Title	Journal	Year
15471878	The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2 Haegebarth, A, Heap, D, Bie, W, Derry, JJ, Richard, S, Tyner, AL	J. Biol. Chem.	2004
10913193	Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability Derry, JJ, Richard, S, Valderrama Carvajal, H, Ye, X, Vasioukhin, V, Cochrane, AW, Chen, T, Tyner, AL	Mol. Cell. Biol.	2000
16179349	Tyrosine phosphorylation of sam68 by breast tumor kinase regulates intranuclear localization and cell cycle progression Lukong, KE, Larocque, D, Tyner, AL, Richard, S	J. Biol. Chem.	2005
19439179	BRK phosphorylates PSF promoting its cytoplasmic localization and cell cycle arrest Lukong, KE, Huot, ME, Richard, S	Cell. Signal.	2009