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FBXL4 [cytosol]
Stable Identifier
R-HSA-8850899
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
F-box/LRR-repeat protein 4, FBXL4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
F-box protein [cytosol] (Homo sapiens)
FBXL4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKA2 FBXL4
Gene Names
FBXL4, FBL4, FBL5
Chain
chain:1-621
Reference Genes
BioGPS Gene:26235 FBXL4
COSMIC (genes):FBXL4 FBXL4
CTD Gene:26235 FBXL4
dbSNP Gene:26235 FBXL4
ENSEMBL:ENSG00000112234 FBXL4
ENSEMBL_homo_sapiens_GENE:ENSG00000112234.9 FBXL4
HGNC:13601 FBXL4
KEGG Gene (Homo sapiens):26235 FBXL4
Monarch:26235 FBXL4
NCBI Gene:26235 FBXL4
OMIM:605654 FBXL4
UCSC:Q9UKA2 FBXL4
Reference Transcript
RefSeq:NM_001278716.1 FBXL4
RefSeq:NM_012160.4 FBXL4
RefSeq:XM_017010726.1 FBXL4
Other Identifiers
11728800_s_at
11747380_a_at
17021888
209943_3p_at
209943_PM_at
209943_at
235450_PM_at
235450_at
236994_PM_at
236994_at
26235
2966083
2966084
2966085
2966086
2966087
2966088
2966089
2966090
2966091
2966092
2966096
2966097
2966103
2966109
2966110
2966113
2966116
2966120
2966121
2966122
2966123
2966124
2966125
2966130
39987_at
74830_at
78618_at
8128356
A_23_P214739
A_24_P129205
A_32_P67610
GE472290
GE56064
GO:0000151
GO:0000422
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005829
GO:0006511
GO:0006914
GO:0007005
GO:0016607
GO:0019005
GO:0030163
GO:0031146
GO:0043226
HMNXSV003018769
HMNXSV003030457
Hs.132809.0.A1_3p_at
Hs.134482.0.A1_3p_at
ILMN_1671393
PH_hs_0003444
PH_hs_0007963
PH_hs_0035983
TC06001961.hg
g6103636_3p_at
g6103636_3p_x_at
Participates
as a member of
F-box protein [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
FBXL4 [cytosol]
(Bos taurus)
FBXL4 [cytosol]
(Canis familiaris)
FBXL4 [cytosol]
(Gallus gallus)
FBXL4 [cytosol]
(Sus scrofa)
zgc:92297 [cytosol]
(Danio rerio)
Fbxl4 [cytosol]
(Drosophila melanogaster)
Fbxl4 [cytosol]
(Mus musculus)
Fbxl4 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001265645.1
,
NP_036292.2
,
XP_016866215.1
OpenTargets
ENSG00000112234
HPA
ENSG00000112234-FBXL4
GeneCards
Q9UKA2
Ensembl
ENSG00000112234
,
ENST00000229971
,
ENSP00000358247
,
ENSP00000229971
,
ENST00000369244
PRO
Q9UKA2
Pharos - Targets
Q9UKA2
Orphanet
22557
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14773 TPP1
1
TPP1 [lysosomal lumen]
(R-HSA-535504)
0.556
3
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