Reactome | SKP1 [nucleoplasm]

SKP1 [nucleoplasm]

Stable Identifier

R-HSA-187538

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Skp1

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External Reference Information

External Reference

UniProt:P63208 SKP1

Gene Names

SKP1, EMC19, OCP2, SKP1A, TCEB1L

Chain

initiator methionine:, chain:2-163

Reference Genes

BioGPS Gene:6500 SKP1

COSMIC (genes):SKP1 SKP1

CTD Gene:6500 SKP1

dbSNP Gene:6500 SKP1

ENSEMBL:ENSG00000113558 SKP1

HGNC:10899 SKP1

KEGG:hsa:6500 SKP1

Monarch:6500 SKP1

NCBI Gene:6500 SKP1

OMIM:601434 SKP1

UCSC:P63208 SKP1

Reference Transcript

Participates

as a component of

Other forms of this molecule

SKP1 [cytosol]

Inferred To

skr-1 [nucleoplasm] (Caenorhabditis elegans)

skp1 [nucleoplasm] (Danio rerio)

skp1 [nucleoplasm] (Schizosaccharomyces pombe)

skp1 [nucleoplasm] (Xenopus tropicalis)

fpaB-1 [nucleoplasm] (Dictyostelium discoideum)

SkpA [nucleoplasm] (Drosophila melanogaster)

SKP1 [nucleoplasm] (Bos taurus)

SKP1 [nucleoplasm] (Canis familiaris)

SKP1 [nucleoplasm] (Gallus gallus)

SKP1 [nucleoplasm] (Saccharomyces cerevisiae)

SKP1 [nucleoplasm] (Sus scrofa)

Homologues of SKP1 [nucleoplasm] (Dictyostelium discoideum)

Skp1 [nucleoplasm] (Mus musculus)

Skp1 [nucleoplasm] (Rattus norvegicus)

fpaA [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_733779.1, NP_008861.2

OpenTargets

ENSG00000113558

ENSEMBL

ENST00000522855, ENST00000353411, ENST00000517625, ENSP00000231487, ENSG00000113558, ENSP00000429472, ENSP00000429686, ENST00000522552, ENSP00000429961

GeneCards

SKP1

HPA

ENSG00000113558-SKP1

PRO

P63208

Pharos - Targets

P63208

GlyGen

P63208

PDB

5IBK, 1FS1, 6M91, 6M92, 8OR3, 6VCD, 5VZT, 5JH5, 1LDK, 3WSO, 6WCQ, 7T1Y, 2AST, 2E32, 8CDK, 4I6J, 8CDJ, 1P22, 9JKB, 5XYL, 6TTU, 6WNX, 5K35, 8BYA, 2OVR, 7B5M, 6BVA, 6M90, 6BYH, 1FS2, 6M93, 6M94, 8OR0, 6W66, 8OR4, 7Z8B, 7T1Z, 5VZU, 2ASS, 2E31, 7ZBW, 7ZBZ, 8BYL, 3L2O, 1FQV, 7Z8T, 5V4B, 2OVQ, 7B5L, 6O60, 7B5R, 6C16, 2OVP, 7Z8V

Interactors (108)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y297 BTRC	2	BTRC [cytosol] (R-HSA-174237) BTRC [nucleoplasm] (R-HSA-3361753)	0.962	27
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.957	20
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.952	18
UniProt:Q9UKB1 FBXW11	1	FBXW11 [cytosol] (R-HSA-976035)	0.934	14
UniProt:Q86XK2 FBXO11	1	FBXO11 [cytosol] (R-HSA-8955092)	0.92	11
UniProt:Q9NVF7 FBX28			0.909	14
UniProt:Q9UKA1 FBXL5	1	FBXL5 [cytosol] (R-HSA-391295)	0.905	15
UniProt:Q96CD0 FBXL8	1	FBXL8 [cytosol] (R-HSA-8850912)	0.905	17
UniProt:Q9UKT5 FBXO4	1	FBXO4 [cytosol] (R-HSA-391298)	0.904	19
UniProt:Q96EF6 FBXO17	1	FBXO17 [cytosol] (R-HSA-976036)	0.895	19
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.891	11
UniProt:Q9UK99 FBX3			0.888	12
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.851	14
UniProt:Q9UKC9 FBXL2			0.847	9
UniProt:Q8NHM5 KDM2B	1	KDM2B [nucleoplasm] (R-HSA-3214398)	0.839	8
UniProt:Q8N5M4 TTC9C			0.832	13
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.821	11
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.818	7
UniProt:Q969U6 FBXW5	1	FBXW5 [cytosol] (R-HSA-391286)	0.818	7
UniProt:Q9H4M3 FBXO44	1	FBXO44 [cytosol] (R-HSA-976031)	0.801	8
UniProt:Q9UKT4 FBXO5	6	p-S182-FBXO5 [cytosol] (R-HSA-177324) p-S145,S149-FBXO5 [cytosol] (R-HSA-174207) FBXO5 [nucleoplasm] (R-HSA-174060) p-S182-FBXO5 [nucleoplasm] (R-HSA-176447) p-S145,S149-FBXO5 [nucleoplasm] (R-HSA-174220) p-FBXO5 [nucleoplasm] (R-HSA-163049)	0.801	8
UniProt:Q9NRD1 FBXO6	1	FBXO6 [cytosol] (R-HSA-391296)	0.8	9
UniProt:Q9NXK8 FBXL12	1	FBXL12 [cytosol] (R-HSA-8862611)	0.8	10
UniProt:Q8NEZ5 FBXO22	1	FBXO22 [cytosol] (R-HSA-8862600)	0.8	10
UniProt:Q8N1E6 FBXL14	1	FBXL14 [cytosol] (R-HSA-8862603)	0.8	6
UniProt:Q6PJ61 FBX46			0.788	7
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.784	7
UniProt:Q6P050 FBXL22	1	FBXL22 [cytosol] (R-HSA-8862597)	0.765	7
UniProt:Q9Y2K7 KDM2A	1	KDM2A [nucleoplasm] (R-HSA-3214392)	0.744	6
UniProt:Q96IG2 FBXL20	1	FBXL20 [cytosol] (R-HSA-8862591)	0.742	7
UniProt:Q9UF56 FBXL17	1	FBXL17 [nucleoplasm] (R-HSA-9708570)	0.737	16
UniProt:Q6W2J9 BCOR			0.725	5
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.725	6
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.725	6
UniProt:Q9BSM1 PCGF1			0.725	6
UniProt:Q5XUX1 FBXW9	1	FBXW9 [cytosol] (R-HSA-391290)	0.716	7
UniProt:O94952 FBXO21	1	FBXO21 [cytosol] (R-HSA-8862592)	0.708	10
UniProt:P54253 ATX1			0.696	6
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.692	3
UniProt:Q8N3Y1 FBXW8	1	FBXW8 [cytosol] (R-HSA-976017)	0.669	5
UniProt:Q7Z6M2 FBX33			0.669	5
UniProt:P57775 FBXW4	1	FBXW4 [cytosol] (R-HSA-391305)	0.669	3
UniProt:Q9UK97 FBXO9	1	FBXO9 [cytosol] (R-HSA-8862608)	0.669	5
UniProt:Q9H4M3-2 FBXO44			0.666	6
UniProt:Q8TCJ0-3 FBXO25			0.666	4
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.662	9
UniProt:Q8N531 FBXL6			0.659	3
UniProt:Q6P3S6 FBX42			0.643	5
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.643	5
UniProt:P20248 CCNA2	5	p-S154-CCNA2 [nucleoplasm] (R-HSA-9929512) p-S154-CCNA2 [cytosol] (R-HSA-9929551) CCNA2 [nucleoplasm] (R-HSA-68905) CCNA2 [cytosol] (R-HSA-157444) PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099)	0.643	4
UniProt:Q6PCT2 FBXL19	1	FBXL19 [cytosol] (R-HSA-8862607)	0.643	5
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.643	5
UniProt:Q8TB52 FBXO30	1	FBXO30 [cytosol] (R-HSA-8862619)	0.643	5
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.643	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.641	4
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.638	3
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	3
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.564	4
UniProt:Q4G163 FBX43			0.556	3
UniProt:Q8NI29 FBXO27	1	FBXO27 [cytosol] (R-HSA-976039)	0.556	3
UniProt:Q96IX9 A26L1			0.556	3
UniProt:A0A0B4J1Y2 A0A0B4J1Y2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q7L273 KCTD9			0.556	3
IntAct:EBI-22514577 CCSB ORF ID			0.556	3
UniProt:Q13309-2 SKP2			0.556	5
UniProt:P25791 LMO2	1	LMO2 [nucleoplasm] (R-HSA-8956513)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
IntAct:EBI-10220632 119369			0.556	3
UniProt:Q9UK97-2 FBXO9			0.556	3
UniProt:Q5FWF7 FBX48			0.556	5
UniProt:Q9ULD2-3 MTUS1			0.556	3
UniProt:Q8BFZ4 Fbxl21	1	Fbxl21 [cytosol] (R-MMU-9932861)	0.547	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.547	2
UniProt:Q8C4V4 Fbxl3	2	Fbxl3 [nucleoplasm] (R-MMU-508623) Fbxl3 [cytosol] (R-MMU-391289)	0.547	3
UniProt:Q9Y2Z0-2 SUGT1			0.544	2
UniProt:P38936 CDKN1A	5	CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.536	3
UniProt:Q16526 CRY1	5	K48polyUb-K,p-S-CRY1 [nucleoplasm] (R-HSA-517931) K48polyUb-K107,p-S-CRY1 [cytosol] (R-HSA-9932884) p-S-CRY1 [cytosol] (R-HSA-400270) p-S-CRY1 [nucleoplasm] (R-HSA-400340) CRY1 [cytosol] (R-HSA-400247)	0.527	4
UniProt:Q92530 PSMF1	1	PSMF1 [cytosol] (R-HSA-68818)	0.527	4
UniProt:Q9UH90 FBXO40	1	FBXO40 [cytosol] (R-HSA-8862612)	0.527	3
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	4
UniProt:Q8WUF8 ARB2A			0.527	4
UniProt:Q96ME1 FBXL18	1	FBXL18 [cytosol] (R-HSA-8854063)	0.527	4
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.527	2
UniProt:Q9HC35 EML4	12	EML4 [cytosol] (R-HSA-9647741) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4(1-496)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119)	0.527	3
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.527	3
UniProt:Q008S8 ECT2L			0.527	2
UniProt:Q9ULD2 MTUS1			0.527	4
UniProt:Q8NFZ0 FBH1			0.527	4
UniProt:Q8TCJ0 FBX25			0.527	2
UniProt:P0C2W1 FBSP1			0.527	4
UniProt:O75592 MYCB2			0.527	4
UniProt:Q6PIJ6 FBX38			0.527	4
UniProt:Q9UK96 FBXO10	1	FBXO10 [cytosol] (R-HSA-8862618)	0.527	3
UniProt:Q9UKA2 FBXL4	1	FBXL4 [cytosol] (R-HSA-8850899)	0.527	4
UniProt:Q5H9F3 BCORL			0.527	2
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.527	3
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	3
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	13
UniProt:Q49AN0 CRY2	5	CRY2 [cytosol] (R-HSA-400255) p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) K48polyUb-K126,p-S-CRY2 [cytosol] (R-HSA-9932882) K48polyUb-K,p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	4
UniProt:P46527 CDKN1B	8	p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.524	2
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.508	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4
UniProt:P49768 PSEN1	6	PSEN1(299-467) [plasma membrane] (R-HSA-2534245) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [plasma membrane] (R-HSA-201606)	0.462	3

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