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SKP1 [nucleoplasm]
Stable Identifier
R-HSA-187538
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Skp1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Association of Cks1 with SCF(Skp2) complex (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Ubiquitination of phospho-p27/p21 (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Homo sapiens)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
BTRC binds p-S344, 347 NFE2L2 (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1 (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:p-S344, S347 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
BTRC:SKP1:CUL1:RBX1:ub,p-S335, S338 NFE2L2 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Regulation of BACH1 activity (Homo sapiens)
BACH1:FBXL17 binds SCF(SKP2) complex (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Homo sapiens)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Circadian clock (Homo sapiens)
Degradation of CRY and PER proteins (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2 (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1:p-S-CRY1,2 [nucleoplasm] (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1:p-S-CRY1,2 [nucleoplasm] (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner (Homo sapiens)
NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
NPM1p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1 (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
NPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
FBXW7 Mutants and NOTCH1 in Cancer (Homo sapiens)
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling (Homo sapiens)
FBXW7 WD mutants do not bind NICD1 (Homo sapiens)
FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
SCF(SKP2) complex binds RUNX2 (Homo sapiens)
RUNX2:SCF(SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
SCF(SKP2) polyubiquitinates RUNX2 (Homo sapiens)
RUNX2:SCF(SKP2) [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
Phosphorylated NICD1 binds FBXW7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Ubiquitination of NICD1 by FBWX7 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
p-NICD1:FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
FBXW7 promotes ubiquitination of p-NICD4 (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SKP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63208 SKP1
Gene Names
SKP1, EMC19, OCP2, SKP1A, TCEB1L
Chain
initiator methionine:, chain:2-163
Reference Genes
BioGPS Gene:6500 SKP1
COSMIC (genes):SKP1 SKP1
CTD Gene:6500 SKP1
dbSNP Gene:6500 SKP1
ENSEMBL:ENSG00000113558 SKP1
HGNC:10899 SKP1
KEGG:hsa:6500 SKP1
Monarch:6500 SKP1
NCBI Gene:6500 SKP1
OMIM:601434 SKP1
UCSC:P63208 SKP1
Reference Transcript
RefSeq:NM_170679.2 SKP1
RefSeq:NM_006930.3 SKP1
Participates
as a component of
CUL1:RBX1:SKP1:p-S354 ZC3HC1 [nucleoplasm] (Homo sapiens)
CUL1:RBX1:SKP1:ZC3HC1 [nucleoplasm] (Homo sapiens)
FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
FBXL3:CUL1:SKP1:RBX1 [nucleoplasm] (Homo sapiens)
BTRC:SKP1:RBX1:CUL1 [nucleoplasm] (Homo sapiens)
FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
SCF (SKP2) complex [nucleoplasm] (Homo sapiens)
CUL1:SKP1:SKP2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SKP1 [cytosol]
Inferred To
skr-1 [nucleoplasm]
(Caenorhabditis elegans)
skp1 [nucleoplasm]
(Danio rerio)
skp1 [nucleoplasm]
(Schizosaccharomyces pombe)
skp1 [nucleoplasm]
(Xenopus tropicalis)
fpaB-1 [nucleoplasm]
(Dictyostelium discoideum)
SkpA [nucleoplasm]
(Drosophila melanogaster)
SKP1 [nucleoplasm]
(Bos taurus)
SKP1 [nucleoplasm]
(Canis familiaris)
SKP1 [nucleoplasm]
(Gallus gallus)
SKP1 [nucleoplasm]
(Saccharomyces cerevisiae)
SKP1 [nucleoplasm]
(Sus scrofa)
Homologues of SKP1 [nucleoplasm]
(Dictyostelium discoideum)
Skp1 [nucleoplasm]
(Mus musculus)
Skp1 [nucleoplasm]
(Rattus norvegicus)
fpaA [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_733779.1
,
NP_008861.2
OpenTargets
ENSG00000113558
ENSEMBL
ENST00000522855
,
ENST00000353411
,
ENST00000517625
,
ENSP00000231487
,
ENSG00000113558
,
ENSP00000429472
,
ENSP00000429686
,
ENST00000522552
,
ENSP00000429961
GeneCards
SKP1
HPA
ENSG00000113558-SKP1
PRO
P63208
Pharos - Targets
P63208
GlyGen
P63208
PDB
5IBK
,
1FS1
,
6M91
,
6M92
,
8OR3
,
6VCD
,
5VZT
,
5JH5
,
1LDK
,
3WSO
,
6WCQ
,
7T1Y
,
2AST
,
2E32
,
8CDK
,
4I6J
,
8CDJ
,
1P22
,
9JKB
,
5XYL
,
6TTU
,
6WNX
,
5K35
,
8BYA
,
2OVR
,
7B5M
,
6BVA
,
6M90
,
6BYH
,
1FS2
,
6M93
,
6M94
,
8OR0
,
6W66
,
8OR4
,
7Z8B
,
7T1Z
,
5VZU
,
2ASS
,
2E31
,
7ZBW
,
7ZBZ
,
8BYL
,
3L2O
,
1FQV
,
7Z8T
,
5V4B
,
2OVQ
,
7B5L
,
6O60
,
7B5R
,
6C16
,
2OVP
,
7Z8V
Interactors (108)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.962
27
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.957
20
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.952
18
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.934
14
UniProt:Q86XK2 FBXO11
1
FBXO11 [cytosol]
(R-HSA-8955092)
0.92
11
UniProt:Q9NVF7 FBX28
0.909
14
UniProt:Q9UKA1 FBXL5
1
FBXL5 [cytosol]
(R-HSA-391295)
0.905
15
UniProt:Q96CD0 FBXL8
1
FBXL8 [cytosol]
(R-HSA-8850912)
0.905
17
UniProt:Q9UKT5 FBXO4
1
FBXO4 [cytosol]
(R-HSA-391298)
0.904
19
UniProt:Q96EF6 FBXO17
1
FBXO17 [cytosol]
(R-HSA-976036)
0.895
19
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.891
11
UniProt:Q9UK99 FBX3
0.888
12
UniProt:Q9UK22 FBXO2
1
FBXO2 [cytosol]
(R-HSA-976044)
0.851
14
UniProt:Q9UKC9 FBXL2
0.847
9
UniProt:Q8NHM5 KDM2B
1
KDM2B [nucleoplasm]
(R-HSA-3214398)
0.839
8
UniProt:Q8N5M4 TTC9C
0.832
13
UniProt:Q969H0 FBXW7
1
FBXW7 [cytosol]
(R-HSA-391304)
0.821
11
UniProt:Q9UKT8 FBXW2
1
FBXW2 [cytosol]
(R-HSA-391300)
0.818
7
UniProt:Q969U6 FBXW5
1
FBXW5 [cytosol]
(R-HSA-391286)
0.818
7
UniProt:Q9H4M3 FBXO44
1
FBXO44 [cytosol]
(R-HSA-976031)
0.801
8
UniProt:Q9UKT4 FBXO5
6
p-S182-FBXO5 [cytosol]
(R-HSA-177324)
p-S145,S149-FBXO5 [cytosol]
(R-HSA-174207)
FBXO5 [nucleoplasm]
(R-HSA-174060)
p-S182-FBXO5 [nucleoplasm]
(R-HSA-176447)
p-S145,S149-FBXO5 [nucleoplasm]
(R-HSA-174220)
p-FBXO5 [nucleoplasm]
(R-HSA-163049)
0.801
8
UniProt:Q9NRD1 FBXO6
1
FBXO6 [cytosol]
(R-HSA-391296)
0.8
9
UniProt:Q9NXK8 FBXL12
1
FBXL12 [cytosol]
(R-HSA-8862611)
0.8
10
UniProt:Q8NEZ5 FBXO22
1
FBXO22 [cytosol]
(R-HSA-8862600)
0.8
10
UniProt:Q8N1E6 FBXL14
1
FBXL14 [cytosol]
(R-HSA-8862603)
0.8
6
UniProt:Q6PJ61 FBX46
0.788
7
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.784
7
UniProt:Q6P050 FBXL22
1
FBXL22 [cytosol]
(R-HSA-8862597)
0.765
7
UniProt:Q9Y2K7 KDM2A
1
KDM2A [nucleoplasm]
(R-HSA-3214392)
0.744
6
UniProt:Q96IG2 FBXL20
1
FBXL20 [cytosol]
(R-HSA-8862591)
0.742
7
UniProt:Q9UF56 FBXL17
1
FBXL17 [nucleoplasm]
(R-HSA-9708570)
0.737
16
UniProt:Q6W2J9 BCOR
0.725
5
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.725
6
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.725
6
UniProt:Q9BSM1 PCGF1
0.725
6
UniProt:Q5XUX1 FBXW9
1
FBXW9 [cytosol]
(R-HSA-391290)
0.716
7
UniProt:O94952 FBXO21
1
FBXO21 [cytosol]
(R-HSA-8862592)
0.708
10
UniProt:P54253 ATX1
0.696
6
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.692
3
UniProt:Q8N3Y1 FBXW8
1
FBXW8 [cytosol]
(R-HSA-976017)
0.669
5
UniProt:Q7Z6M2 FBX33
0.669
5
UniProt:P57775 FBXW4
1
FBXW4 [cytosol]
(R-HSA-391305)
0.669
3
UniProt:Q9UK97 FBXO9
1
FBXO9 [cytosol]
(R-HSA-8862608)
0.669
5
UniProt:Q9H4M3-2 FBXO44
0.666
6
UniProt:Q8TCJ0-3 FBXO25
0.666
4
UniProt:P41002 CCNF
1
CCNF [cytosol]
(R-HSA-8862602)
0.662
9
UniProt:Q8N531 FBXL6
0.659
3
UniProt:Q6P3S6 FBX42
0.643
5
UniProt:Q99496 RNF2
1
RNF2 [nucleoplasm]
(R-HSA-389119)
0.643
5
UniProt:P20248 CCNA2
5
p-S154-CCNA2 [nucleoplasm]
(R-HSA-9929512)
p-S154-CCNA2 [cytosol]
(R-HSA-9929551)
CCNA2 [nucleoplasm]
(R-HSA-68905)
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
0.643
4
UniProt:Q6PCT2 FBXL19
1
FBXL19 [cytosol]
(R-HSA-8862607)
0.643
5
UniProt:Q06587 RING1
1
RING1 [nucleoplasm]
(R-HSA-389113)
0.643
5
UniProt:Q8TB52 FBXO30
1
FBXO30 [cytosol]
(R-HSA-8862619)
0.643
5
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.643
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.641
4
UniProt:Q96FJ2 DYNLL2
4
DYNLL2 [cytosol]
(R-HSA-2029024)
DYNLL2 [plasma membrane]
(R-HSA-140527)
DYNLL2 [cilium]
(R-HSA-5624865)
DYNLL2 [ciliary tip]
(R-HSA-5625337)
0.638
3
UniProt:P11440 Cdk1
11
phospho-p-T161-CDK1 [nucleoplasm]
(R-MMU-170066)
phospho-p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-MMU-170074)
phospho-p-T161-CDK1 [cytosol]
(R-MMU-157415)
phospho-p-T14,Y15,T161-CDK1 [cytosol]
(R-MMU-170071)
CDK1 [cytosol]
(R-MMU-170075)
Cdk1 [nucleoplasm]
(R-MMU-1362302)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(R-MMU-170078)
phospho-p-T14-CDK1 [nucleoplasm]
(R-MMU-170045)
phospho-p-T14-CDK1 [cytosol]
(R-MMU-170064)
phospho-p-Y4-CDK1 [cytosol]
(R-MMU-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-MMU-264424)
0.623
3
UniProt:Q5XUX0 FBXO31
1
FBXO31 [cytosol]
(R-HSA-8850911)
0.564
4
UniProt:Q4G163 FBX43
0.556
3
UniProt:Q8NI29 FBXO27
1
FBXO27 [cytosol]
(R-HSA-976039)
0.556
3
UniProt:Q96IX9 A26L1
0.556
3
UniProt:A0A0B4J1Y2 A0A0B4J1Y2
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q7L273 KCTD9
0.556
3
IntAct:EBI-22514577 CCSB ORF ID
0.556
3
UniProt:Q13309-2 SKP2
0.556
5
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.556
3
UniProt:Q96GX9 APIP
1
APIP [cytosol]
(R-HSA-1237171)
0.556
3
IntAct:EBI-10220632 119369
0.556
3
UniProt:Q9UK97-2 FBXO9
0.556
3
UniProt:Q5FWF7 FBX48
0.556
5
UniProt:Q9ULD2-3 MTUS1
0.556
3
UniProt:Q8BFZ4 Fbxl21
1
Fbxl21 [cytosol]
(R-MMU-9932861)
0.547
3
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.547
2
UniProt:Q8C4V4 Fbxl3
2
Fbxl3 [nucleoplasm]
(R-MMU-508623)
Fbxl3 [cytosol]
(R-MMU-391289)
0.547
3
UniProt:Q9Y2Z0-2 SUGT1
0.544
2
UniProt:P38936 CDKN1A
5
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.536
3
UniProt:Q16526 CRY1
5
K48polyUb-K,p-S-CRY1 [nucleoplasm]
(R-HSA-517931)
K48polyUb-K107,p-S-CRY1 [cytosol]
(R-HSA-9932884)
p-S-CRY1 [cytosol]
(R-HSA-400270)
p-S-CRY1 [nucleoplasm]
(R-HSA-400340)
CRY1 [cytosol]
(R-HSA-400247)
0.527
4
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.527
4
UniProt:Q9UH90 FBXO40
1
FBXO40 [cytosol]
(R-HSA-8862612)
0.527
3
UniProt:Q14999 CUL7
1
CUL7 [cytosol]
(R-HSA-535534)
0.527
4
UniProt:Q8WUF8 ARB2A
0.527
4
UniProt:Q96ME1 FBXL18
1
FBXL18 [cytosol]
(R-HSA-8854063)
0.527
4
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.527
2
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.527
2
UniProt:Q9HC35 EML4
12
EML4 [cytosol]
(R-HSA-9647741)
p-S,T-EML4 [cytosol]
(R-HSA-9648096)
EML4(1-496)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699812)
EML4(1-223)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699862)
EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699813)
EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9716113)
EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol]
(R-HSA-9716116)
EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699903)
EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9699885)
EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699918)
EML4(1-569)-ALK(1078-1620) fusion [cytosol]
(R-HSA-9716112)
EML4(1-780)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9716119)
0.527
3
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.527
3
UniProt:Q008S8 ECT2L
0.527
2
UniProt:Q9ULD2 MTUS1
0.527
4
UniProt:Q8NFZ0 FBH1
0.527
4
UniProt:Q8TCJ0 FBX25
0.527
2
UniProt:P0C2W1 FBSP1
0.527
4
UniProt:O75592 MYCB2
0.527
4
UniProt:Q6PIJ6 FBX38
0.527
4
UniProt:Q9UK96 FBXO10
1
FBXO10 [cytosol]
(R-HSA-8862618)
0.527
3
UniProt:Q9UKA2 FBXL4
1
FBXL4 [cytosol]
(R-HSA-8850899)
0.527
4
UniProt:Q5H9F3 BCORL
0.527
2
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.527
3
UniProt:Q14155 ARHGEF7
1
ARHGEF7 [cytosol]
(R-HSA-430346)
0.527
3
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
NEDD8 [cytosol]
(R-HSA-416969)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
0.527
3
UniProt:Q15052 ARHGEF6
1
ARHGEF6 [cytosol]
(R-HSA-195017)
0.527
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.527
13
UniProt:Q49AN0 CRY2
5
CRY2 [cytosol]
(R-HSA-400255)
p-S-CRY2 [nucleoplasm]
(R-HSA-400328)
p-S-CRY2 [cytosol]
(R-HSA-400305)
K48polyUb-K126,p-S-CRY2 [cytosol]
(R-HSA-9932882)
K48polyUb-K,p-S-CRY2 [nucleoplasm]
(R-HSA-517935)
0.527
4
UniProt:P46527 CDKN1B
8
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.524
2
UniProt:P61962 DCAF7
2
DCAF7 [nucleoplasm]
(R-HSA-8863312)
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
0.508
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
UniProt:P05919 vpu
6
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
4
UniProt:P49768 PSEN1
6
PSEN1(299-467) [plasma membrane]
(R-HSA-2534245)
PSEN1(1-298) [plasma membrane]
(R-HSA-2534298)
PSEN1(1-298) [azurophil granule membrane]
(R-HSA-6799209)
PSEN1(1-467) [azurophil granule membrane]
(R-HSA-6799235)
PSEN1(299-467) [azurophil granule membrane]
(R-HSA-6799234)
PSEN1(1-467) [plasma membrane]
(R-HSA-201606)
0.462
3
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