F-box protein [cytosol]

Stable Identifier
R-HSA-976085
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Synonyms
substrate recognition component of a SCF E3 ligase complex
Locations in the PathwayBrowser
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General
F-box proteins were first characterized as components of SCF ubiquitin-ligase complexes (named after their main components, SkpI, Cullin, and an F-box protein), in which they bind substrates for ubiquitin-mediated proteolysis. The F-box motif links the F-box protein to other components of the SCF complex by binding the core SCF component SkpI.
Literature References
PubMed ID Title Journal Year
10531035 Identification of a family of human F-box proteins

Guardavaccaro, D, Chiaur, DS, Vidal, M, Pagano, M, Parks, W, Cenciarelli, C

Curr. Biol. 1999
21145461 Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics

Bennett, EJ, Gygi, SP, Rush, J, Harper, JW

Cell 2010
Participants
members
Participates
as a component of
Inferred To
F-box protein [cytosol] (Bos taurus)
F-box protein [cytosol] (Caenorhabditis elegans)
F-box protein [cytosol] (Canis familiaris)
F-box protein [cytosol] (Danio rerio)
F-box protein [cytosol] (Dictyostelium discoideum)
F-box protein [cytosol] (Drosophila melanogaster)
F-box protein [cytosol] (Gallus gallus)
F-box protein [cytosol] (Mus musculus)
F-box protein [cytosol] (Plasmodium falciparum)
F-box protein [cytosol] (Rattus norvegicus)
F-box protein [cytosol] (Saccharomyces cerevisiae)
F-box protein [cytosol] (Schizosaccharomyces pombe)
F-box protein [cytosol] (Sus scrofa)
F-box protein [cytosol] (Xenopus tropicalis)
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