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PEX7 [peroxisomal membrane]
Stable Identifier
R-HSA-9033493
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
peroxisomal membrane
Synonyms
Peroxisomal targeting signal 2 receptor, PEX7_HUMAN
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
Cargo of PEX5L:PEX7 translocates from the cytosol to the peroxisomal matrix (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14:PEX1:PEX6:PEX26:ZFAND6 [peroxisomal membrane] (Homo sapiens)
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX7 [peroxisomal membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00628 PEX7
Gene Names
PEX7, PTS2R
Chain
chain:1-323
Reference Genes
BioGPS Gene:5191 PEX7
COSMIC (genes):PEX7 PEX7
CTD Gene:5191 PEX7
dbSNP Gene:5191 PEX7
ENSEMBL:ENSG00000112357 PEX7
ENSEMBL_homo_sapiens_GENE:ENSG00000112357.14 PEX7
HGNC:8860 PEX7
KEGG Gene (Homo sapiens):5191 PEX7
Monarch:5191 PEX7
NCBI Gene:5191 PEX7
OMIM:601757 PEX7
UCSC:O00628 PEX7
Reference Transcript
RefSeq:NM_000288.3 PEX7
Other Identifiers
11722338_at
17012888
205420_PM_at
205420_at
211033_PM_s_at
211033_s_at
2927254
2927256
2927257
2927258
2927259
2927261
2927262
2927268
2927269
2927270
2927271
2927272
2927273
2927275
2927279
2927280
2927281
40654_at
5191
80931_at
8122242
A_14_P101723
A_23_P93543
A_33_P3412095
GE59524
GO:0001764
GO:0001958
GO:0005053
GO:0005515
GO:0005737
GO:0005777
GO:0005778
GO:0005782
GO:0005829
GO:0006625
GO:0006629
GO:0006635
GO:0006886
GO:0007031
GO:0008611
GO:0015031
GO:0016558
GO:0019899
GO:0030154
GO:0042803
GO:0043226
GO:0048856
GO:0048870
GO:0055085
HMNXSV003028490
ILMN_1729650
PH_hs_0004617
TC06001019.hg
U88871_at
g13623327_3p_s_at
g4505730_3p_at
Participates
as a component of
PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] (Homo sapiens)
PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12 [peroxisomal membrane] (Homo sapiens)
Other forms of this molecule
PEX7 [cytosol]
Inferred To
Ghost homologue of PEX7 [peroxisomal membrane]
(Caenorhabditis elegans)
Ghost homologue of PEX7 [peroxisomal membrane]
(Xenopus tropicalis)
Pex7 [peroxisomal membrane]
(Drosophila melanogaster)
Pex7 [peroxisomal membrane]
(Mus musculus)
Pex7 [peroxisomal membrane]
(Rattus norvegicus)
pex7 [peroxisomal membrane]
(Dictyostelium discoideum)
pex7 [peroxisomal membrane]
(Schizosaccharomyces pombe)
PEX7 [peroxisomal membrane]
(Bos taurus)
PEX7 [peroxisomal membrane]
(Canis familiaris)
PEX7 [peroxisomal membrane]
(Gallus gallus)
PEX7 [peroxisomal membrane]
(Saccharomyces cerevisiae)
PEX7 [peroxisomal membrane]
(Sus scrofa)
Cross References
RefSeq
NP_000279.1
OpenTargets
ENSG00000112357
GeneCards
O00628
HPA
ENSG00000112357-PEX7
Ensembl
ENSP00000315680
,
ENST00000541292
,
ENST00000318471
,
ENSP00000441004
,
ENSG00000112357
PRO
O00628
Pharos - Targets
O00628
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P57076 CF298
0.623
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
3
UniProt:P09110 ACAA1
6
ACAA1(1-26) [peroxisomal matrix]
(R-HSA-9033534)
ACAA1(1-424) [peroxisomal matrix]
(R-HSA-9033517)
ACAA1(1-424) [cytosol]
(R-HSA-9033127)
ACAA1 [extracellular region]
(R-HSA-6799680)
ACAA1 [specific granule lumen]
(R-HSA-6799608)
ACAA1 [peroxisomal matrix]
(R-HSA-390238)
0.527
3
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
3
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.527
3
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
3
UniProt:Q9H2J4 PDCL3
0.527
3
UniProt:Q8IYD2 KLD8A
0.527
2
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
3
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.527
3
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
3
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
3
UniProt:Q5I0X4 CF226
0.527
3
UniProt:Q92526 CCT6B
1
CCT6B [cytosol]
(R-HSA-5216201)
0.527
3
UniProt:P61758 VBP1
1
VBP1 [cytosol]
(R-HSA-379543)
0.527
2
UniProt:Q92968 PEX13
2
PEX13 [cytosol]
(R-HSA-9603795)
PEX13 [peroxisomal membrane]
(R-HSA-452790)
0.527
3
UniProt:Q9UQ74 PSG8
1
PSG8 [extracellular region]
(R-HSA-8870757)
0.527
2
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