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CCT8 [secretory granule lumen]
Stable Identifier
R-HSA-6801035
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
T-complex protein 1 subunit theta (TCP-1-theta)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
CCT8 [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50990 CCT8
Gene Names
CCT8, C21orf112, CCTQ, KIAA0002
Chain
initiator methionine:1, chain:2-548
Reference Genes
BioGPS Gene:10694 CCT8
COSMIC (genes):CCT8 CCT8
CTD Gene:10694 CCT8
dbSNP Gene:10694 CCT8
ENSEMBL:ENSG00000156261.13 CCT8
HGNC:1623 CCT8
KEGG Gene (Homo sapiens):10694 CCT8
Monarch:10694 CCT8
NCBI Gene:10694 CCT8
OMIM:617786 CCT8
UCSC:P50990 CCT8
Reference Transcript
RefSeq:NM_006585.3 CCT8
RefSeq:NM_001282909.1 CCT8
RefSeq:NM_001282907.1 CCT8
Other Identifiers
0003440070
10694
11733131_s_at
11752550_x_at
11756850_x_at
11757031_a_at
16924719
200873_PM_s_at
200873_s_at
2433265
2433269
2433271
2433273
3928072
3928073
3928076
3928077
3928078
3928079
3928081
3928083
3928085
3928087
3928089
3928091
3928093
3928094
3928095
3928097
3928102
3928103
3928104
3928105
39767_at
8069753
A_23_P102876
D13627_at
GE57061
GO:0000166
GO:0002199
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005773
GO:0005813
GO:0005815
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0005929
GO:0006457
GO:0007339
GO:0016787
GO:0016887
GO:0022414
GO:0031410
GO:0032200
GO:0032212
GO:0032991
GO:0034774
GO:0035578
GO:0042995
GO:0043226
GO:0044183
GO:0044297
GO:0045111
GO:0045296
GO:0046931
GO:0050821
GO:0051082
GO:0061077
GO:0065003
GO:0070062
GO:0140657
GO:0140662
GO:1901998
GO:1904813
GO:1904851
GO:1904871
GO:1904874
HMNXSV003041563
ILMN_1717868
TC21000353.hg
g6005726_3p_a_at
Participates
as a member of
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
CCT8 [ficolin-1-rich granule lumen]
CCT8 [extracellular region]
CCT8 [azurophil granule lumen]
CCT8 [cytosol]
Inferred To
CCT8 [secretory granule lumen]
(Bos taurus)
CCT8 [secretory granule lumen]
(Canis familiaris)
CCT8 [secretory granule lumen]
(Danio rerio)
CCT8 [secretory granule lumen]
(Drosophila melanogaster)
CCT8 [secretory granule lumen]
(Gallus gallus)
CCT8 [secretory granule lumen]
(Plasmodium falciparum)
CCT8 [secretory granule lumen]
(Saccharomyces cerevisiae)
CCT8 [secretory granule lumen]
(Sus scrofa)
Cct8 [secretory granule lumen]
(Mus musculus)
Cct8 [secretory granule lumen]
(Rattus norvegicus)
cct8 [secretory granule lumen]
(Dictyostelium discoideum)
cct8 [secretory granule lumen]
(Schizosaccharomyces pombe)
cct8 [secretory granule lumen]
(Xenopus tropicalis)
cct-8 [secretory granule lumen]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001269838.1
,
NP_006576.2
,
NP_001269836.1
OpenTargets
ENSG00000156261
GeneCards
P50990
HPA
ENSG00000156261-CCT8
Ensembl
ENSP00000442730
,
ENSG00000156261
,
ENST00000626972
,
ENSP00000286788
,
ENST00000540844
,
ENST00000286788
,
ENSP00000486921
PRO
P50990
Pharos - Targets
P50990
PDB
6NR9
,
7NVO
,
7LUP
,
6NRB
,
7NVN
,
6NR8
,
6NRC
,
7LUM
,
7NVM
,
6QB8
,
6NRD
,
6NRA
,
7NVL
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.643
3
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.564
2
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
0.527
3
UniProt:P04049 RAF1
20
RAF1 [cytosol]
(R-HSA-167205)
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
0.527
3
UniProt:P52333 JAK3
6
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
JAK3 [endosome]
(R-HSA-8983184)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [cytosol]
(R-HSA-451893)
0.527
2
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.527
2
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
3
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
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