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VAMP2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-9609886
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Vesicle-associated membrane protein 2, VAMP2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Protein localization (Homo sapiens)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored protein:ASNA1:ADP:WRB:CAMLG dissociates yielding Tail-anchored protein in the endoplasmic reticulum membrane (Homo sapiens)
Tail-anchored proteins [endoplasmic reticulum membrane] (Homo sapiens)
VAMP2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63027 VAMP2
Gene Names
VAMP2, SYB2
Chain
initiator methionine:, chain:2-116
Reference Genes
BioGPS Gene:6844 VAMP2
COSMIC (genes):VAMP2 VAMP2
CTD Gene:6844 VAMP2
dbSNP Gene:6844 VAMP2
ENSEMBL:ENSG00000220205 VAMP2
HGNC:12643 VAMP2
KEGG:hsa:6844 VAMP2
Monarch:6844 VAMP2
NCBI Gene:6844 VAMP2
OMIM:185881 VAMP2
UCSC:P63027 VAMP2
Reference Transcript
RefSeq:NM_014232.2 VAMP2
Other Identifiers
11716067_at
11716068_a_at
16840876
201556_PM_s_at
201556_s_at
201557_PM_at
201557_at
214792_PM_x_at
214792_x_at
32254_at
3744218
3744219
3744220
3744221
3744222
3744223
3744224
3744225
3744226
3744227
3744228
6844
8012376
A_23_P164341
A_24_P313576
A_33_P3213493
A_33_P3409886
GE62982
GO:0000149
GO:0002376
GO:0005484
GO:0005515
GO:0005516
GO:0005543
GO:0005802
GO:0005829
GO:0005886
GO:0006887
GO:0006906
GO:0008021
GO:0008076
GO:0008289
GO:0009749
GO:0015031
GO:0016020
GO:0016079
GO:0016192
GO:0017075
GO:0017156
GO:0017157
GO:0019905
GO:0030136
GO:0030141
GO:0030667
GO:0030669
GO:0030672
GO:0031201
GO:0031410
GO:0031982
GO:0032869
GO:0035493
GO:0042589
GO:0043001
GO:0043005
GO:0043226
GO:0043231
GO:0043308
GO:0044306
GO:0045202
GO:0048306
GO:0048471
GO:0048488
GO:0060090
GO:0060203
GO:0060291
GO:0060627
GO:0061024
GO:0061025
GO:0061202
GO:0065003
GO:0070032
GO:0070033
GO:0070044
GO:0070083
GO:0072659
GO:0090316
GO:1902259
HMNXSV003039309
Hs.194534.1.A1_3p_a_at
Hs.194534.1.A1_3p_x_at
ILMN_1713491
ILMN_1911044
M36205_at
PH_hs_0002231
TC17002850.hg
g12803794_3p_a_at
g12803794_3p_x_at
g7657674_3p_at
g7657674_3p_x_at
Participates
as a member of
Tail-anchored proteins [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
VAMP2 [clathrin-sculpted monoamine transport vesicle membrane]
VAMP2 [plasma membrane]
VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
VAMP2 [clathrin-sculpted glutamate transport vesicle membrane]
VAMP2 [synaptic vesicle membrane]
VAMP2(59-116) [synaptic vesicle membrane]
VAMP2(2-58) [cytosol]
VAMP2(2-76) [cytosol]
VAMP2(77-116) [synaptic vesicle membrane]
VAMP2(60-116) [synaptic vesicle membrane]
VAMP2(2-59) [cytosol]
VAMP2(82-116) [synaptic vesicle membrane]
VAMP2(2-81) [cytosol]
VAMP2 [secretory granule membrane]
VAMP2 [cytosol]
VAMP2 [cytoplasmic vesicle membrane]
VAMP2 [lysosomal membrane]
VAMP2 [Golgi membrane]
VAMP2 [clathrin-coated endocytic vesicle membrane]
Cross References
RefSeq
NP_055047.2
OpenTargets
ENSG00000220205
ENSEMBL
ENSP00000314214
,
ENST00000316509
HPA
ENSG00000220205-VAMP2
PRO
P63027
Pharos - Targets
P63027
PDB
3RL0
,
7UDC
,
3FII
,
3FIE
,
3RK3
,
3RK2
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60880-2 SNAP25
0.764
9
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.718
6
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.666
5
UniProt:O95721 SNAP29
3
SNAP29 [azurophil granule membrane]
(R-HSA-6799359)
SNAP29 [plasma membrane]
(R-HSA-2029020)
SNAP29 [Golgi membrane]
(R-HSA-6810997)
0.666
4
UniProt:P61266 STX1B
3
STX1B(1-?) [cytosol]
(R-HSA-5246520)
STX1B(?-288) [plasma membrane]
(R-HSA-5246519)
STX1B [plasma membrane]
(R-HSA-181479)
0.659
4
UniProt:O14810 CPLX1
1
CPLX1 [cytosol]
(R-HSA-210385)
0.656
3
UniProt:Q8IWB7 WDFY1
0.643
3
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.632
5
UniProt:O94806 PRKD3
1
PRKD3 [cytosol]
(R-HSA-58212)
0.618
7
UniProt:O55012
3
Picalm [Golgi membrane]
(R-RNO-434341)
Picalm [cytoplasmic vesicle membrane]
(R-RNO-429812)
Picalm [cytosol]
(R-RNO-8867593)
0.558
2
UniProt:Q57236 Q57236
0.558
3
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.556
3
IntAct:EBI-22326698 CCSB ORF ID
0.556
3
UniProt:P32856-2 STX2
0.556
3
UniProt:Q5T0T0 MARH8
0.556
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:Q8TBB6 S7A14
0.556
3
UniProt:Q7Z5P4 HSD17B13
1
HSD17B13 [cytosol]
(R-HSA-8862029)
0.556
3
UniProt:Q3SXY8 ARL13B
8
PolyUb-Misfolded ARL13B [lysosomal lumen]
(R-HSA-9660004)
PolyUb-Misfolded ARL13B [cytosol]
(R-HSA-9641129)
Ub-Misfolded ARL13B [cytosol]
(R-HSA-9641119)
Misfolded ARL13B [cytosol]
(R-HSA-9640110)
Misfolded ARL13B [cilium]
(R-HSA-9640116)
ARL13B [cilium]
(R-HSA-5618181)
PolyUb-Misfolded ARL13B [late endosome lumen]
(R-HSA-9659986)
ARL13B [plasma membrane]
(R-HSA-9716787)
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q8IWU4 SLC30A8
2
SLC30A8 [Golgi membrane]
(R-HSA-9817561)
SLC30A8 [secretory granule membrane]
(R-HSA-437106)
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8N661 TMEM86B
1
TMEM86B [endoplasmic reticulum membrane]
(R-HSA-8874443)
0.556
3
UniProt:Q3ZAQ7 VMA21
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q8N5M9 JAGN1
0.556
3
UniProt:P31937 HIBADH
1
HIBADH [mitochondrial matrix]
(R-HSA-70882)
0.556
3
UniProt:Q96IK0 TM101
0.556
3
UniProt:Q9HA82 CERS4
1
CERS4 [endoplasmic reticulum membrane]
(R-HSA-428138)
0.556
3
UniProt:Q9NY72 SCN3B
1
SCN3B [plasma membrane]
(R-HSA-197921)
0.556
3
UniProt:Q9Y282 ERGI3
0.556
3
UniProt:O75558 STX11
0.527
2
UniProt:Q8N4C7 STX19
0.527
2
UniProt:Q86Y82 STX12
0.527
4
UniProt:Q16563 SYPL1
0.527
2
UniProt:Q8NHX9 TPCN2
1
TPCN2 [lysosomal membrane]
(R-HSA-2685518)
0.527
2
UniProt:P54920 NAPA
1
NAPA [cytosol]
(R-HSA-264469)
0.527
2
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