Reactome | VCP [secretory granule lumen]

VCP [secretory granule lumen]

Stable Identifier

R-HSA-6801039

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

p97 ATPase, Transitional endoplasmic reticulum ATPase, TERA_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P55072 VCP

Gene Names

VCP

Chain

initiator methionine:1, chain:2-806

Reference Genes

BioGPS Gene:7415 VCP

COSMIC (genes):VCP VCP

CTD Gene:7415 VCP

dbSNP Gene:7415 VCP

ENSEMBL:ENSG00000165280 VCP

ENSEMBL:ENSG00000165280.18 VCP

HGNC:12666 VCP

KEGG Gene (Homo sapiens):7415 VCP

Monarch:7415 VCP

NCBI Gene:7415 VCP

OMIM:601023 VCP

Reference Transcript

RefSeq:NM_007126.3 VCP

Other Identifiers

11733010_a_at

11745875_x_at

11746412_x_at

11758451_s_at

17093570

208648_PM_at

208648_at

208649_PM_s_at

208649_s_at

3204407

3204408

3204409

3204410

3204412

3204414

3204415

3204417

3204419

3204420

3204421

3204422

3204423

3204425

3204426

3204429

3204430

3204432

3204433

3204435

3204437

3204440

3204441

3204454

33818_at

44058_at

56348_at

7415

8160914

A_23_P83045

A_24_P295412

GE54792

GE79640

GO:0000166

GO:0000278

GO:0000502

GO:0003723

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005811

GO:0005829

GO:0006091

GO:0006281

GO:0006302

GO:0006511

GO:0006734

GO:0006886

GO:0006888

GO:0006914

GO:0006919

GO:0006974

GO:0006996

GO:0007010

GO:0008289

GO:0010494

GO:0010498

GO:0010918

GO:0012501

GO:0016192

GO:0016236

GO:0016567

GO:0016787

GO:0016887

GO:0019079

GO:0019903

GO:0019904

GO:0019985

GO:0023052

GO:0030163

GO:0030433

GO:0030968

GO:0030970

GO:0031334

GO:0031410

GO:0031593

GO:0031625

GO:0032436

GO:0032510

GO:0032991

GO:0034098

GO:0034330

GO:0034605

GO:0034774

GO:0035578

GO:0035617

GO:0035800

GO:0035861

GO:0036211

GO:0036297

GO:0036435

GO:0036503

GO:0036513

GO:0042288

GO:0042802

GO:0042981

GO:0043161

GO:0043226

GO:0043231

GO:0043531

GO:0044389

GO:0044877

GO:0045184

GO:0045202

GO:0045732

GO:0045879

GO:0046034

GO:0048471

GO:0050807

GO:0051228

GO:0055086

GO:0061857

GO:0065003

GO:0070062

GO:0070842

GO:0071712

GO:0072389

GO:0090263

GO:0097352

GO:0098772

GO:0098978

GO:0106300

GO:0120186

GO:0140036

GO:0140657

GO:1901135

GO:1903006

GO:1903007

GO:1903715

GO:1903843

GO:1903862

GO:1904288

GO:1904813

GO:1904949

GO:1905634

GO:1990381

GO:1990730

GO:2000060

GO:2001171

HMNXSV003053327

Hs.106357.0.S2_3p_at

ILMN_1777220

PH_hs_0024763

TC09001048.hg

TC09002468.hg

g5410289_3p_a_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

Me3K315-VCP [cytosol]

VCP [endoplasmic reticulum membrane]

VCP [nucleoplasm]

VCP [azurophil granule lumen]

VCP [extracellular region]

VCP [ficolin-1-rich granule lumen]

VCP [cytosol]

Inferred To

cdcD [secretory granule lumen] (Dictyostelium discoideum)

VCP [secretory granule lumen] (Bos taurus)

VCP [secretory granule lumen] (Caenorhabditis elegans)

VCP [secretory granule lumen] (Canis familiaris)

VCP [secretory granule lumen] (Danio rerio)

VCP [secretory granule lumen] (Drosophila melanogaster)

VCP [secretory granule lumen] (Gallus gallus)

VCP [secretory granule lumen] (Mus musculus)

VCP [secretory granule lumen] (Plasmodium falciparum)

VCP [secretory granule lumen] (Rattus norvegicus)

VCP [secretory granule lumen] (Saccharomyces cerevisiae)

VCP [secretory granule lumen] (Schizosaccharomyces pombe)

VCP [secretory granule lumen] (Sus scrofa)

VCP [secretory granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_009057.1

OpenTargets

ENSG00000165280

ZINC - Substances

TERA_HUMAN

ZINC target

P55072

PRO

P55072

PDB

5FTK, 7LMY, 7R7S, 5IFW, 7BPA, 6HD0, 5C19, 7VCU, 4P0A, 7L5W, 7RLD, 5IFS, 7VCV, 7BPB, 7LMZ, 7L5X, 5X4L, 5KIY, 7RLF, 3QQ8, 7RL7, 5KIW, 7K57, 4KO8, 3QC8, 4KDL, 6G2X, 7RLH, 7RLG, 7RL9, 3QQ7, 4KLN, 7OAT, 7BP8, 5GLF, 5C1B, 7RLA, 4KDI, 7VCS, 6G2Z, 5B6C, 6G2V, 7LN5, 7MHS, 5C1A, 5FTL, 5DYI, 5FTJ, 3HU2, 3HU3, 5EPP, 7RLC, 5DYG, 7R7T, 7LN0, 6MCK, 4KOD, 7RL6, 3EBB, 7K56, 7R7U, 7VCX, 6G2W, 3HU1, 7LN1, 5C18, 7LN2, 3TIW, 7PUX, 7LN3, 7JY5, 7K59, 6G2Y, 7MDM, 5FTN, 6G30, 7LN4, 7MDO, 7BP9, 3QWZ, 7RLI, 5FTM, 7RLB, 7RLJ, 7LN6, 7VCT

IntEnz

3.6.4.6

GeneCards

P55072

HPA

ENSG00000165280-VCP

Ensembl

ENSG00000165280, ENSP00000351777, ENST00000358901

Pharos - Targets

P55072

ZINC - Predictions - Purchasable

TERA_HUMAN

Orphanet

15706

HMDB Protein

HMDBP11971

Interactors (66)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UNZ2 NSFL1C	1	NSFL1C [cytosol] (R-HSA-9714673)	0.951	20
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.946	28
UniProt:P68543 UBX2A			0.881	17
UniProt:Q9UKV5 AMFR	1	AMFR [endoplasmic reticulum membrane] (R-HSA-975999)	0.874	12
UniProt:Q9BZV1 UBXN6			0.872	20
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.848	9
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.846	7
UniProt:P54252-1 ATXN3			0.833	18
UniProt:Q96CS3 FAF2	3	FAF2 [cytosol] (R-HSA-6781921) FAF2 [extracellular region] (R-HSA-6806183) FAF2 [azurophil granule lumen] (R-HSA-6799138)	0.776	13
UniProt:O94888 UBXN7	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.77	18
UniProt:Q14CS0 UBX2B			0.766	11
UniProt:Q92890 UFD1	2	UFD1L [nucleoplasm] (R-HSA-5654993) UFD1 [cytosol] (R-HSA-9668519)	0.743	5
UniProt:Q969W3 F104A			0.718	6
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.675	4
UniProt:Q92575 UBXN4			0.667	11
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.666	4
UniProt:Q9H0K1 SIK2			0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.643	3
UniProt:Q9UNN5-1 FAF1			0.618	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	13
UniProt:O00124 UBXN8			0.604	8
UniProt:Q96LJ8 UBX10			0.604	7
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.573	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.57	3
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q8NBI5 S43A3			0.556	3
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P26378-2 P263782			0.556	3
UniProt:Q16560-2 SNRNP35			0.556	3
UniProt:Q96J88-3 Q96J883			0.556	3
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q9Y263 PLAP			0.556	3
UniProt:O60941-5 DTNB			0.556	3
UniProt:Q96LK0 CEP19			0.556	3
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.556	3
UniProt:O94941 UBOX5	1	UBOX5 [cytosol] (R-HSA-976034)	0.556	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	3
UniProt:P24278 ZBT25			0.556	3
UniProt:P32969 RPL9	1	RPL9 [cytosol] (R-HSA-72492)	0.556	3
UniProt:Q9H7H0-2 METTL17			0.556	3
UniProt:Q8WZA0 LZIC			0.556	3
UniProt:Q9Y4L5 RNF115	1	RNF115 [cytosol] (R-HSA-8850904)	0.556	3
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.556	3
UniProt:Q07869 PPARA	2	monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099) PPARA [nucleoplasm] (R-HSA-400186)	0.556	3
UniProt:Q9BUN8 DERL1	1	DERL1 [endoplasmic reticulum membrane] (R-HSA-6781898)	0.527	2
UniProt:Q96IV0 NGLY1	1	NGLY1 [cytosol] (R-HSA-8850591)	0.527	2
UniProt:P04114 APOB	20	APOB(28-2179) [cytosol] (R-HSA-2395786) APOB(28-2179) [early endosome] (R-HSA-2429651) APOB(28-4563) [lysosomal lumen] (R-HSA-8876369) APOB(28-2179) [endosome lumen] (R-HSA-174716) APOB(28-2179) [endosome membrane] (R-HSA-174762) APOB(28-4563) [plasma membrane] (R-HSA-171089) APOB(28-4563) [clathrin-coated endocytic vesicle membrane] (R-HSA-171155) APOB(28-4563) [endosome lumen] (R-HSA-171119) APOB(28-4563) [endosome membrane] (R-HSA-171121) APOB(28-2179) [clathrin-coated endocytic vesicle membrane] (R-HSA-174788) APOB(28-2179) [plasma membrane] (R-HSA-174625) APOB(28-2179) [endoplasmic reticulum lumen] (R-HSA-174620) APOB(28-2179) [extracellular region] (R-HSA-174770) APOB(28-2179) [endoplasmic reticulum membrane] (R-HSA-174637) APOB(28-4563) [smooth endoplasmic reticulum] (R-HSA-8866317) APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2512789) 10xdHF-10xglutamyl semialdehyde (Pro)-6xL-tyrosine residue-3xOxoH-2xmodified L-lysine residue-N'-formyl-L-kynurenine-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239461) AcK-APOB(28-4563) [endocytic vesicle lumen] (R-HSA-2239446) AcK-APOB(28-4563) [extracellular region] (R-HSA-2173751) p-APOB(28-4563) [endoplasmic reticulum lumen] (R-HSA-8957068)	0.527	2
UniProt:B1AQ61 B1AQ61			0.525	4
UniProt:O96017 CHEK2	3	CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825) p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784)	0.524	2
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.524	2
UniProt:O94868 FCSD2			0.508	2
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.499	2
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.499	2
UniProt:Q9UNN5 FAF1			0.499	2
UniProt:Q9WTX6 Cul1	3	Cul1 [cytosol] (R-MMU-8952519) Cul1 [nucleoplasm] (R-MMU-9008723) Cul1 [cytosol] (R-MMU-174230)	0.499	2
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.488	2
UniProt:Q5T124-6 UBXN11			0.471	7
UniProt:Q86TM6 SYVN1	1	SYVN1(1-617) [endoplasmic reticulum membrane] (R-HSA-535496)	0.462	2
UniProt:P04578-PRO_0000038428 ENV			0.462	2

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