Reactome | EP300-S-S-FOXO4 [nucleoplasm]

EP300-S-S-FOXO4 [nucleoplasm]

Stable Identifier

R-HSA-9617681

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P98177 FOXO4

Gene Names

FOXO4, AFX, AFX1, MLLT7

Chain

chain:1-505

Reference Genes

BioGPS Gene:4303 FOXO4

COSMIC (genes):FOXO4 FOXO4

CTD Gene:4303 FOXO4

dbSNP Gene:4303 FOXO4

ENSEMBL:ENSG00000184481 FOXO4

HGNC:7139 FOXO4

KEGG:hsa:4303 FOXO4

Monarch:4303 FOXO4

NCBI Gene:4303 FOXO4

OMIM:300033 FOXO4

UCSC:P98177 FOXO4

Reference Transcript

Participates

as a component of

EP300-S-S-FOXO4:FOXO4-S-S-EP300 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

FOXO4 [nucleoplasm]

p-T32,S197,S262-FOXO4 [nucleoplasm]

p-T32,S197,S262-FOXO4 [cytosol]

SOH-C481-FOXO4 [nucleoplasm]

CREBBP-S-S-FOXO4 [nucleoplasm]

Ac-K-FOXO4 [nucleoplasm]

PolyUb-FOXO4 [nucleoplasm]

Modified Residues

Name

Inter-chain Crosslink via L-cystine (cross-link) at 481 and unknown

Coordinate

481

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_005929.2, NP_001164402.1

OpenTargets

ENSG00000184481

ENSEMBL

ENST00000374259, ENSG00000184481, ENSP00000363377, ENST00000341558, ENSP00000342209

HPA

ENSG00000184481-FOXO4

GeneCards

FOXO4

PRO

P98177

Pharos - Targets

P98177

GlyGen

P98177

PDB

1E17, 3L2C

HMDB Protein

HMDBP08863

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.675	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	3
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.544	3
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.524	2
UniProt:P98177 FOXO4	8	FOXO4 [nucleoplasm] (R-HSA-5690183) p-T32,S197,S262-FOXO4 [nucleoplasm] (R-HSA-199314) p-T32,S197,S262-FOXO4 [cytosol] (R-HSA-9614415) SOH-C481-FOXO4 [nucleoplasm] (R-HSA-9617655) CREBBP-S-S-FOXO4 [nucleoplasm] (R-HSA-9617679) EP300-S-S-FOXO4 [nucleoplasm] (R-HSA-9617681) Ac-K-FOXO4 [nucleoplasm] (R-HSA-9617761) PolyUb-FOXO4 [nucleoplasm] (R-HSA-6782501)	0.499	2

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