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LRSAM1 [cytosol]
Stable Identifier
R-HSA-976004
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase LRSAM1, LRSM1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
LRSAM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6UWE0 LRSAM1
Gene Names
LRSAM1, TAL, UNQ6496/PRO21356
Chain
chain:1-723
Reference Genes
BioGPS Gene:90678 LRSAM1
COSMIC (genes):LRSAM1 LRSAM1
CTD Gene:90678 LRSAM1
dbSNP Gene:90678 LRSAM1
ENSEMBL:ENSG00000148356 LRSAM1
HGNC:25135 LRSAM1
KEGG:hsa:90678 LRSAM1
Monarch:90678 LRSAM1
NCBI Gene:90678 LRSAM1
OMIM:610933 LRSAM1
UCSC:Q6UWE0 LRSAM1
Reference Transcript
RefSeq:NM_138361.5 LRSAM1
RefSeq:NM_001384142.1 LRSAM1
RefSeq:NM_001005374.4 LRSAM1
RefSeq:XM_017015283.1 LRSAM1
RefSeq:NM_001005373.4 LRSAM1
RefSeq:NM_001190723.3 LRSAM1
Other Identifiers
11755662_a_at
17089324
227675_PM_at
227675_at
235449_PM_at
235449_at
2671681
3189863
3189865
3189866
3189867
3189868
3189869
3189870
3189871
3189872
3189873
3189874
3189875
3189876
3189877
3189878
3189880
3189882
3189883
3189887
3189888
3189889
3189890
3189891
3189892
3189894
3189895
3189897
3189898
3189899
3189901
3189902
3189903
3189904
3189905
3189907
3189908
3189909
3189910
3189911
3189912
3189913
62473_at
8158028
90678
A_14_P110696
A_19_P00810156
A_23_P123916
GE62518
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005829
GO:0006914
GO:0008270
GO:0015031
GO:0016020
GO:0016567
GO:0016740
GO:0030163
GO:0045806
GO:0046755
GO:0046872
GO:0051865
GO:0061630
GO:0070086
GO:0140096
GO:1904417
GO:2000786
HMNXSV003025614
HMNXSV003055996
Hs.323813.0.S1_3p_at
Hs.58372.0.A1_3p_at
Hs.58372.0.A1_3p_x_at
ILMN_1683355
ILMN_1774856
ILMN_1811102
PH_hs_0016118
PH_hs_0040666
TC09000666.hg
TC09002268.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Lrsam1 [cytosol]
(Mus musculus)
Lrsam1 [cytosol]
(Rattus norvegicus)
LRSAM1 [cytosol]
(Canis familiaris)
LRSAM1 [cytosol]
(Gallus gallus)
LRSAM1 [cytosol]
(Sus scrofa)
lrsam1 [cytosol]
(Danio rerio)
Sclp [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001005374.1
,
NP_001371071.1
,
NP_001005373.1
,
NP_612370.3
,
XP_016870772.1
,
NP_001177652.1
OpenTargets
ENSG00000148356
ENSEMBL
ENSP00000322937
,
ENSP00000300417
,
ENST00000373322
,
ENST00000373324
,
ENSP00000501592
,
ENST00000300417
,
ENST00000675448
,
ENSP00000502167
,
ENSP00000362419
,
ENSG00000148356
,
ENST00000675883
,
ENSP00000362421
,
ENST00000323301
HPA
ENSG00000148356-LRSAM1
GeneCards
LRSAM1
PRO
Q6UWE0
Pharos - Targets
Q6UWE0
Orphanet
LRSAM1
GlyGen
Q6UWE0
HMDB Protein
HMDBP09325
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99816 TSG101
2
TSG101 [endosome membrane]
(R-HSA-2980549)
TSG101 [cytosol]
(R-HSA-917727)
0.83
8
UniProt:P61088 UBE2N
5
UBE2N [cytosol]
(R-HSA-206072)
Ub-C87-UBE2N [cytosol]
(R-HSA-8864210)
UBE2N [nucleoplasm]
(R-HSA-5682541)
K63polyUb-C87-UBE2N [nucleoplasm]
(R-HSA-6790511)
Ub-C87-UBE2N [nucleoplasm]
(R-HSA-8943013)
0.692
3
UniProt:Q6GPH4 XAF1
1
XAF1 [cytosol]
(R-HSA-1015680)
0.556
3
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