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Ub-C87-UBE2N [cytosol]
Stable Identifier
R-HSA-8864210
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBE2N(1-152), Ubc13
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
PRKN ubiquitinates MOM substrates (Homo sapiens)
Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Homo sapiens)
Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Homo sapiens)
Ub-C87-UBE2N:UBE2V1 [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF152 binds RRAGA:GDP and Ubiquitin:UBE2D3 (Homo sapiens)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Homo sapiens)
Ub:UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
Ub:UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
RNF152 polyubiquitinates RRAGA (Homo sapiens)
RNF152:RRAGA:GDP:Ub:UBE2N [lysosomal membrane] (Homo sapiens)
Ub:UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
Ub:UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)
RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
RNF181 polyubiquinates BCL10 (Homo sapiens)
RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61088 UBE2N
Gene Names
UBE2N, BLU
Chain
chain:1-152
Reference Genes
BioGPS Gene:7334 UBE2N
COSMIC (genes):UBE2N UBE2N
CTD Gene:7334 UBE2N
dbSNP Gene:7334 UBE2N
ENSEMBL:ENSG00000177889 UBE2N
HGNC:12492 UBE2N
KEGG:hsa:7334 UBE2N
Monarch:7334 UBE2N
NCBI Gene:7334 UBE2N
OMIM:603679 UBE2N
UCSC:P61088 UBE2N
Reference Transcript
RefSeq:NM_003348.3 UBE2N
Other Identifiers
11718482_at
11718483_s_at
11753695_s_at
1660_at
16768528
201523_3p_x_at
201523_PM_x_at
201523_x_at
201524_PM_x_at
201524_x_at
212751_PM_at
212751_at
2355641
2355642
2355643
2793764
3133962
3133963
3465777
3465778
3465780
3465782
3465784
3465786
3465787
3465788
3465789
3465790
3465792
3465793
3465794
3465795
3465796
3465797
3465798
3465799
3465800
3465801
3465802
3465803
3465810
3465815
3465817
3465818
3556518
36604_at
7334
7965471
A_23_P116829
A_23_P341471
D83004_at
GE79028
GE85923
GO:0000151
GO:0000209
GO:0000724
GO:0000729
GO:0002376
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006281
GO:0006282
GO:0006301
GO:0006310
GO:0006355
GO:0006511
GO:0016567
GO:0016740
GO:0019787
GO:0030163
GO:0031371
GO:0031372
GO:0031625
GO:0032446
GO:0032991
GO:0043123
GO:0043130
GO:0043161
GO:0043226
GO:0045739
GO:0050852
GO:0051092
GO:0061631
GO:0070062
GO:0070534
GO:0097027
GO:0098542
GO:0098772
GO:0140096
GO:0140374
GO:1902523
GO:1902533
GO:1904262
GO:2000781
HMNXSV003013479
Hs.75355.0.A1_3p_a_at
Hs.75355.0.A1_3p_s_at
Hs.75355.1.A1_3p_at
ILMN_1793651
PH_hs_0030462
TC12001815.hg
g4507792_3p_a_at
Participates
as a member of
Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
as a component of
Ub:UBE2N [cytosol] (Homo sapiens)
Ub-C87-UBE2N:UBE2V1 [cytosol] (Homo sapiens)
Other forms of this molecule
UBE2N [cytosol]
UBE2N [nucleoplasm]
K63polyUb-C87-UBE2N [nucleoplasm]
Ub-C87-UBE2N [nucleoplasm]
Inferred To
Ghost homologue of Ub-C87-UBE2N [cytosol]
(Rattus norvegicus)
ubc-13 [cytosol]
(Caenorhabditis elegans)
Ub-C87-UBE2N [cytosol]
(Gallus gallus)
Ub-C87-UBE2N [cytosol]
(Plasmodium falciparum)
Dmel\CG3473 [cytosol]
(Drosophila melanogaster)
ubc13 [cytosol]
(Schizosaccharomyces pombe)
Homologues of Ub-C87-UBE2N [cytosol]
(Drosophila melanogaster)
UBE2N [cytosol]
(Bos taurus)
UBE2N [cytosol]
(Canis familiaris)
UBE2N [cytosol]
(Sus scrofa)
Ube2n [cytosol]
(Mus musculus)
ben [cytosol]
(Drosophila melanogaster)
UBC13 [cytosol]
(Saccharomyces cerevisiae)
ube2n [cytosol]
(Dictyostelium discoideum)
ube2n [cytosol]
(Xenopus tropicalis)
ube2na [cytosol]
(Danio rerio)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 87
Coordinate
87
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_003339.1
ENSEMBL
ENST00000318066
,
ENSP00000316176
OpenTargets
ENSG00000177889
IntEnz
2.3.2.23
HPA
ENSG00000177889-UBE2N
ZINC - Substances
UBE2N_HUMAN
ZINC target
P61088
PRO
P61088
Pharos - Targets
P61088
GlyGen
P61088
HMDB Protein
HMDBP00654
PDB
6D6I
,
3W31
,
1J7D
,
4DHZ
,
3VON
,
6KG6
,
5EYA
,
5H7S
,
4WHV
,
4IP3
,
7BBF
,
3HCU
,
2C2V
,
3HCT
,
6JKY
,
5VO0
,
7BBD
,
6LP2
,
4NR3
,
6S53
,
6UMP
,
4DHI
,
5VNZ
,
7BXG
,
4NRI
,
4ONL
,
5AIU
,
6KL4
,
4TKP
,
6UMS
,
4ONM
,
4DHJ
,
4NRG
,
4ORH
,
6P5B
,
6ULH
,
4ONN
,
6KFP
,
5YWR
,
5AIT
Interactors (33)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13404 UBE2V1
1
UBE2V1 [cytosol]
(R-HSA-205753)
0.91
22
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.847
9
UniProt:Q8ND25 ZNRF1
1
ZNRF1 [cytosol]
(R-HSA-8850903)
0.822
7
UniProt:Q15819 UBE2V2
2
UBE2V2 [cytosol]
(R-HSA-947624)
UBE2V2 [nucleoplasm]
(R-HSA-5682543)
0.811
6
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.75
5
UniProt:Q13049 TRIM32
1
TRIM32 [cytosol]
(R-HSA-976030)
0.731
4
UniProt:Q9Y3C5 RNF11
0.729
4
UniProt:Q96FW1 OTUB1
2
OTUB1 [nucleoplasm]
(R-HSA-6783242)
OTUB1 [cytosol]
(R-HSA-933411)
0.725
5
UniProt:Q6UWE0 LRSAM1
1
LRSAM1 [cytosol]
(R-HSA-976004)
0.692
3
UniProt:Q14527 HLTF
1
HLTF [nucleoplasm]
(R-HSA-8855007)
0.677
4
UniProt:Q96F44 TRIM11
1
TRIM11 [cytosol]
(R-HSA-976033)
0.672
3
UniProt:P22314 UBA1
2
UBA1 [cytosol]
(R-HSA-947698)
UBA1 [nucleoplasm]
(R-HSA-8852116)
0.638
3
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.592
2
UniProt:Q13489 BIRC3
3
BIRC3 [cytosol]
(R-HSA-50845)
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.592
2
UniProt:O43567 RNF13
0.592
2
UniProt:Q8N6D2 RNF182
1
RNF182 [cytosol]
(R-HSA-976010)
0.592
2
UniProt:Q6PCD5 RFWD3
0.592
2
UniProt:Q96FW1-1 OTUB1
0.591
5
UniProt:Q8VSD5 Q8VSD5
0.558
2
UniProt:Q9XVR6
4
OTUB2 [cytosol]
(R-CEL-933410)
OTUB1 [nucleoplasm]
(R-CEL-6783242)
OTUB2 [nucleoplasm]
(R-CEL-6783260)
OTUB1 [cytosol]
(R-CEL-933411)
0.558
2
UniProt:P62158 CALM
0.553
2
UniProt:Q9UKV5 AMFR
1
AMFR [endoplasmic reticulum membrane]
(R-HSA-975999)
0.553
2
UniProt:Q13404-2 UBE2V1
0.544
2
UniProt:Q62925
2
MAP3K1 [cytosol]
(R-RNO-166866)
phospho-p-T1400,T1412-MAP3K1 [cytosol]
(R-RNO-2685607)
0.527
46
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.527
2
UniProt:Q96RN5 MED15
1
MED15 [nucleoplasm]
(R-HSA-556827)
0.508
2
UniProt:Q8NEH6 MNS1
0.508
2
UniProt:Q8NHG8 ZNRF2
1
ZNRF2 [cytosol]
(R-HSA-8850901)
0.508
2
UniProt:Q9UKJ5 CHIC2
0.508
2
UniProt:Q86SQ7 SDCCAG8
1
SDCCAG8 [cytosol]
(R-HSA-380273)
0.508
2
UniProt:Q149N8-1 SHPRH
0.499
2
UniProt:Q96EP1 CHFR
0.488
2
UniProt:Q86Y13 DZIP3
1
DZIP3 [cytosol]
(R-HSA-976002)
0.488
2
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