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phospho-p-S166,S188-MDM2 [cytosol]
Stable Identifier
R-MMU-198638
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P23804
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional Regulation by TP53 (Mus musculus)
Regulation of TP53 Activity (Mus musculus)
Regulation of TP53 Expression and Degradation (Mus musculus)
Regulation of TP53 Degradation (Mus musculus)
AKT phosphorylates MDM2 (Mus musculus)
phospho-p-S166,S188-MDM2 [cytosol] (Mus musculus)
MDM2 translocates to the nucleus (Mus musculus)
phospho-p-S166,S188-MDM2 [cytosol] (Mus musculus)
SGK1 phosphorylates MDM2 (Mus musculus)
phospho-p-S166,S188-MDM2 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Intracellular signaling by second messengers (Mus musculus)
PIP3 activates AKT signaling (Mus musculus)
AKT phosphorylates targets in the cytosol (Mus musculus)
AKT phosphorylates MDM2 (Mus musculus)
phospho-p-S166,S188-MDM2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P23804 Mdm2
Gene Names
Mdm2
Chain
chain:1-489
Reference Genes
BioGPS Gene:17246 Mdm2
KEGG:mmu:17246 Mdm2
Monarch:17246 Mdm2
NCBI Gene:17246 Mdm2
UCSC:P23804 Mdm2
Reference Transcript
RefSeq:NM_010786.4 Mdm2
RefSeq:NM_001288586.2 Mdm2
Other Identifiers
10372668
134102_at
1423605_a_at
1427718_a_at
17245248
17246
4349787
4361915
4374099
4390865
4411669
4443464
4512150
4645625
4655546
4715120
4715824
4939417
5009498
5010923
5064302
5140978
5162104
5244241
5295306
5295585
5380022
5432498
5467284
5578089
5580349
5584597
98110_at
A_51_P201346
A_52_P469842
A_55_P1975475
A_55_P2606086
GE35731
GO:0000122
GO:0001568
GO:0001974
GO:0002027
GO:0002039
GO:0003170
GO:0003181
GO:0003203
GO:0003281
GO:0003283
GO:0003723
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006355
GO:0006511
GO:0006915
GO:0006977
GO:0007089
GO:0007507
GO:0008097
GO:0008270
GO:0009410
GO:0009636
GO:0010039
GO:0010468
GO:0010628
GO:0010629
GO:0010955
GO:0010977
GO:0012501
GO:0014069
GO:0016567
GO:0016604
GO:0016740
GO:0016874
GO:0017053
GO:0019899
GO:0019904
GO:0030163
GO:0031625
GO:0031648
GO:0032026
GO:0032436
GO:0032991
GO:0033612
GO:0034504
GO:0042176
GO:0042220
GO:0042802
GO:0042975
GO:0043021
GO:0043066
GO:0043130
GO:0043161
GO:0043226
GO:0043518
GO:0045184
GO:0045472
GO:0045787
GO:0045892
GO:0045931
GO:0046677
GO:0046827
GO:0046872
GO:0048545
GO:0048856
GO:0051149
GO:0051603
GO:0051726
GO:0051865
GO:0060411
GO:0061630
GO:0061663
GO:0065003
GO:0065008
GO:0070301
GO:0071236
GO:0071301
GO:0071312
GO:0071363
GO:0071375
GO:0071391
GO:0071407
GO:0071456
GO:0071480
GO:0071494
GO:0072537
GO:0072717
GO:0097718
GO:0098978
GO:0099149
GO:0099576
GO:0140096
GO:1901797
GO:1902254
GO:1904404
GO:1904707
GO:1904754
GO:1990000
GO:1990785
ILMN_1229882
ILMN_1250774
ILMN_2850753
Msa.1904.0_s_at
aa415488_rc_at
aa415488_rc_g_at
mMC002697
Participates
as an input of
MDM2 translocates to the nucleus (Mus musculus)
as an output of
AKT phosphorylates MDM2 (Mus musculus)
SGK1 phosphorylates MDM2 (Mus musculus)
Other forms of this molecule
PolyUb-MDM2 [nucleoplasm]
monoSUMO1-K182-MDM2 [nucleoplasm]
Mdm2 [cytosol]
MDM2 [plasma membrane]
MDM2 [endocytic vesicle membrane]
phospho-p-5S,T-MDM2 [nucleoplasm]
phospho-PolyUb,p-S166,S188-MDM2 [nucleoplasm]
phospho-p-S166,S188,T218-MDM2 [nucleoplasm]
MDM2 [nucleoplasm]
MDM2 [cytosol]
phospho-p-S166,S188-MDM2 [nucleoplasm]
Inferred From
p-S166,S188-MDM2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 166 (in Homo sapiens)
Coordinate
166
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 188 (in Homo sapiens)
Coordinate
188
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_034916.1
,
NP_001275515.1
ENSEMBL
ENSMUST00000020408
,
ENSMUSP00000100898
,
ENSMUST00000105263
,
ENSMUSP00000020408
,
ENSMUSG00000020184
PRO
P23804
MGI
96952
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02340 Tp53
20
TP53 [cytosol]
(R-MMU-8869337)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-MMU-2997661)
p- S18-Tp53 [nucleoplasm]
(R-MMU-9816424)
phospho-p-S15,S20-TP53 [nucleoplasm]
(R-MMU-69683)
phospho-p-S15-TP53 [nucleoplasm]
(R-MMU-69507)
TP53 [nucleoplasm]
(R-MMU-69488)
PolyUb-TP53 [cytosol]
(R-MMU-6793681)
PolyUb-TP53 [nucleoplasm]
(R-MMU-6793679)
phospho-PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-MMU-6804446)
phospho-p-S15,S20,S46-TP53 [nucleoplasm]
(R-MMU-6798369)
phospho-p-T55-TP53 [nucleoplasm]
(R-MMU-6805400)
phospho-p-S15,S20,S392-TP53 [nucleoplasm]
(R-MMU-6805053)
phospho-p-S15,S33,S46-TP53 [nucleoplasm]
(R-MMU-6805268)
phospho-p-S15,S392-TP53 [nucleoplasm]
(R-MMU-3222015)
phospho-p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-MMU-6805133)
phospho-p-S37-TP53 [nucleoplasm]
(R-MMU-3239022)
phospho-p-S315-TP53 [nucleoplasm]
(R-MMU-6805106)
phospho-p-S392-TP53 [nucleoplasm]
(R-MMU-9836341)
Me2K-370,382-TP53 [nucleoplasm]
(R-MMU-3222242)
0.918
9
UniProt:Q9CXW4 Rpl11
1
Rpl11 [cytosol]
(R-MMU-9633593)
0.723
4
UniProt:P47962 Rpl5
1
Rpl5 [cytosol]
(R-MMU-9633557)
0.669
3
UniProt:P62991 UBIQ
0.589
2
UniProt:O35618
5
Mdm4 [nucleoplasm]
(R-MMU-6782502)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349461)
phospho-Mdm4 [nucleoplasm]
(R-MMU-349441)
phospho-Mdm4 [nucleoplasm]
(R-MMU-6804938)
Mdm4 [nucleoplasm]
(R-MMU-349430)
0.564
2
UniProt:Q5EBH1 RASF5
0.557
3
UniProt:O88904
1
HIPK1 [nucleoplasm]
(R-MMU-3215224)
0.537
3
UniProt:P62830 Rpl23
1
Rpl23 [cytosol]
(R-MMU-9633465)
0.499
2
UniProt:Q62108 Dlg4
3
SAP-90 [plasma membrane]
(R-MMU-443606)
Dlg4 [endocytic vesicle membrane]
(R-MMU-416847)
Dlg4 [cytosol]
(R-MMU-6794267)
0.463
3
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