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SETD7 [nucleoplasm]
Stable Identifier
R-HSA-1183221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone-lysine N-methyltransferase SETD7, SETD7_HUMAN, KMT7
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4) (Homo sapiens)
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
SETD7 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WTS6 SETD7
Gene Names
SETD7, KIAA1717, KMT7, SET7, SET9
Chain
chain:1-366
Reference Genes
BioGPS Gene:80854 SETD7
COSMIC (genes):SETD7 SETD7
CTD Gene:80854 SETD7
dbSNP Gene:80854 SETD7
ENSEMBL:ENSG00000145391 SETD7
ENSEMBL_homo_sapiens_GENE:ENSG00000145391.14 SETD7
HGNC:30412 SETD7
KEGG Gene (Homo sapiens):80854 SETD7
Monarch:80854 SETD7
NCBI Gene:80854 SETD7
OMIM:606594 SETD7
UCSC:Q8WTS6 SETD7
Reference Transcript
RefSeq:NM_001306199.1 SETD7
RefSeq:NM_030648.3 SETD7
Other Identifiers
11717554_at
11717555_at
16980005
224928_PM_at
224928_at
2786659
2786660
2786661
2786662
2786663
2786666
2786668
2786673
2786680
46280_at
49574_r_at
80854
8102848
A_23_P80966
A_24_P251841
GE87316
GO:0002039
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006325
GO:0006351
GO:0006355
GO:0006974
GO:0008168
GO:0016279
GO:0016740
GO:0018026
GO:0018027
GO:0032259
GO:0034968
GO:0036211
GO:0042054
GO:0043226
GO:0045471
GO:0045893
GO:0070828
GO:0140096
GO:0140938
GO:0140945
HMNXSV003029764
Hs.78521.0.S1_3p_at
ILMN_1720916
PH_hs_0022750
TC04001583.hg
Participates
as a member of
SETD3, SETD7, WHSC1L1, Core MLL complex [nucleoplasm] (Homo sapiens)
Inferred To
SETD7 [nucleoplasm]
(Bos taurus)
SETD7 [nucleoplasm]
(Canis familiaris)
SETD7 [nucleoplasm]
(Dictyostelium discoideum)
SETD7 [nucleoplasm]
(Mus musculus)
SETD7 [nucleoplasm]
(Rattus norvegicus)
SETD7 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001293128.1
,
NP_085151.1
Guide to Pharmacology - Targets
2703
OpenTargets
ENSG00000145391
ZINC - Substances
SETD7_HUMAN
ZINC - Biogenic
SETD7_HUMAN
ZINC target
Q8WTS6
PRO
Q8WTS6
PDB
3M53
,
3M54
,
1XQH
,
1H3I
,
4J8O
,
4JDS
,
3OS5
,
3M58
,
1O9S
,
3M57
,
5EG2
,
4J7I
,
5AYF
,
4J7F
,
3M55
,
3M56
,
3M5A
,
3CBO
,
4JLG
,
1N6C
,
4J83
,
3VV0
,
3CBP
,
3M59
,
1MUF
,
4E47
,
1N6A
,
3CBM
,
2F69
,
1MT6
,
3VUZ
,
5YLT
ZINC - Metabolites
SETD7_HUMAN
HPA
ENSG00000145391-SETD7
GeneCards
Q8WTS6
Ensembl
ENSG00000145391
,
ENSP00000274031
,
ENST00000274031
Pharos - Targets
Q8WTS6
ZINC - Predictions - Purchasable
SETD7_HUMAN
HMDB Protein
HMDBP00404
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.922
11
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.74
9
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.737
12
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.668
11
UniProt:Q96RI1 NR1H4
1
NR1H4 [nucleoplasm]
(R-HSA-5340228)
0.633
5
UniProt:P68433 H3c1
20
H3c8 [nucleoplasm]
(R-MMU-4551293)
H3c8 [nucleoplasm]
(R-MMU-4551291)
H3c8 [nucleoplasm]
(R-MMU-4551292)
H3c8 [nucleoplasm]
(R-MMU-5229052)
H3c8 [nucleoplasm]
(R-MMU-5229062)
H3c8 [nucleoplasm]
(R-MMU-5211328)
H3c8 [nucleoplasm]
(R-MMU-5218935)
AcK9,14-p-S10-histone H3.1 [nucleoplasm]
(R-MMU-8865729)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871271)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871306)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871294)
phospho-H3c8 [nucleoplasm]
(R-MMU-8865596)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871295)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871288)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871299)
phospho-H3c8 [nucleoplasm]
(R-MMU-8871286)
H3c8 [nucleoplasm]
(R-MMU-4754193)
H3c8 [nucleoplasm]
(R-MMU-4722135)
H3c8 [nucleoplasm]
(R-MMU-5649791)
H3c8 [nucleoplasm]
(R-MMU-5649795)
0.558
2
UniProt:Q9WVH4 Foxo3
10
phospho-Foxo3 [nucleoplasm]
(R-MMU-5687010)
phospho-Foxo3 [cytosol]
(R-MMU-5687014)
Foxo3 [cytosol]
(R-MMU-5687032)
Foxo3 [mitochondrial matrix]
(R-MMU-9841824)
Foxo3 [mitochondrial matrix]
(R-MMU-9841849)
Foxo3 [nucleoplasm]
(R-MMU-9620514)
Foxo3 [nucleoplasm]
(R-MMU-9621809)
phospho-Foxo3 [cytosol]
(R-MMU-9614413)
phospho-Foxo3 [nucleoplasm]
(R-MMU-199289)
Foxo3 [nucleoplasm]
(R-MMU-199305)
0.544
5
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