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LEMD3 [nuclear envelope]
Stable Identifier
R-HSA-2993886
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
MAN1, Inner nuclear membrane protein Man1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope Reassembly (Homo sapiens)
Initiation of Nuclear Envelope Reformation (Homo sapiens)
BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD3 [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD3 [nuclear envelope] (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerisation of the Nuclear Lamina (Homo sapiens)
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD3 [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD3 [nuclear envelope] (Homo sapiens)
VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD3 [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
LEMD3 [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2U8 LEMD3
Gene Names
LEMD3, MAN1
Chain
initiator methionine:1, chain:2-911
Reference Genes
BioGPS Gene:23592 LEMD3
COSMIC (genes):LEMD3 LEMD3
CTD Gene:23592 LEMD3
dbSNP Gene:23592 LEMD3
ENSEMBL:ENSG00000174106 LEMD3
HGNC:28887 LEMD3
KEGG Gene (Homo sapiens):23592 LEMD3
Monarch:23592 LEMD3
NCBI Gene:23592 LEMD3
OMIM:607844 LEMD3
UCSC:Q9Y2U8 LEMD3
Reference Transcript
RefSeq:NM_001167614.1 LEMD3
RefSeq:NM_014319.4 LEMD3
Other Identifiers
0004540138
11721227_at
11721228_s_at
11721229_at
16753588
218604_at
23592
25078
2CH0
3420091
3420092
3420093
3420094
3420095
3420096
3420097
3420098
3420099
3420100
3420101
3420102
3420103
3420116
3420120
3420121
3420128
3420129
3420130
3420131
3420132
3420134
3420136
3420137
3420139
3420140
3420141
3420142
54159_at
5ZOJ
5ZOK
72884_at
76986
7956842
A0A024RBB9
A_14_P121448
A_23_P151018
A_33_P3382709
AAD31593
AAF73293
AF112299
AF180135
AF180136
AF180137
AF180138
AF180139
AF180140
AF180141
AF180142
AF263918
AL137533
CAB70796
CCDS8972
CH471054
EAW97148
EAW97149
ENSG00000174106
ENSP00000308369
ENST00000308330
ENST00000308330.2
EntrezGene:23592
EntrezGene:LEMD3
g7706606_3p_at
GE58578
GO:0001525
GO:0003674
GO:0003676
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005635
GO:0005637
GO:0005639
GO:0006997
GO:0006998
GO:0007165
GO:0008150
GO:0009058
GO:0016020
GO:0016021
GO:0030512
GO:0030514
GO:0031965
GO:0032926
GO:0034641
GO:0043226
GO:0048646
GO:0048856
GO:0061024
GO:1902531
HGNC:28887
HPA025078
HPA076986
ILMN_1727361
ILMN_2183938
IPR003887
IPR011015
IPR012677
IPR018996
IPR034394
IPR034997
IPR035979
IPR041885
LEMD3
LEMD3-201
MIM:166700
MIM:607844
NM_001167614
NM_014319
NP_001161086
NP_055134
PF03020
PF09402
PH_hs_0029077
SM00540
TC12000581.hg
UPI000012EB75
Participant Of
hasCandidate
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope]
Inferred To
LEMD3 [nuclear envelope] (Bos taurus)
LEMD3 [nuclear envelope] (Canis familiaris)
LEMD3 [nuclear envelope] (Mus musculus)
LEMD3 [nuclear envelope] (Rattus norvegicus)
LEMD3 [nuclear envelope] (Sus scrofa)
LEMD3 [nuclear envelope] (Xenopus tropicalis)
Cross References
RefSeq
NP_055134.2
,
NP_001161086.1
OpenTargets
ENSG00000174106
GeneCards
Q9Y2U8
PRO
Q9Y2U8
Orphanet
16349
PDB
2CH0
,
5ZOK
,
5ZOJ
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P84022 SMAD3
12
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
SMAD3 [nucleoplasm]
(R-HSA-206150)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
0.564
2
UniProt:Q8BUN5 Smad3
7
phospho-2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-MMU-2187326)
Ub-SMAD3 [cytosol]
(R-MMU-6782830)
phospho-p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-MMU-2176471)
SMAD3 [nucleoplasm]
(R-MMU-206150)
SMAD3 [cytosol]
(R-MMU-170855)
p-S423,425-Smad3 [cytosol]
(R-MMU-9605416)
p-S423,425-Smad3 [nucleoplasm]
(R-MMU-1225907)
0.564
2
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.462
3
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
0.462
4
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