Reactome | LEMD3 [nuclear envelope]

LEMD3 [nuclear envelope]

Stable Identifier

R-HSA-2993886

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

MAN1, Inner nuclear membrane protein Man1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        LEMD3 [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        LEMD3 [nuclear envelope] (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Nuclear Envelope Breakdown (Homo sapiens)
        
        Depolymerisation of the Nuclear Lamina (Homo sapiens)
        
        Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        LEMD3 [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        LEMD3 [nuclear envelope] (Homo sapiens)
        
        VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        LEMD3 [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        LEMD3 [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2U8 LEMD3

Gene Names

LEMD3, MAN1

Chain

initiator methionine:1, chain:2-911

Reference Genes

BioGPS Gene:23592 LEMD3

COSMIC (genes):LEMD3 LEMD3

CTD Gene:23592 LEMD3

dbSNP Gene:23592 LEMD3

ENSEMBL:ENSG00000174106 LEMD3

HGNC:28887 LEMD3

KEGG Gene (Homo sapiens):23592 LEMD3

Monarch:23592 LEMD3

NCBI Gene:23592 LEMD3

OMIM:607844 LEMD3

UCSC:Q9Y2U8 LEMD3

Reference Transcript

Other Identifiers

0004540138

11721227_at

11721228_s_at

11721229_at

16753588

218604_at

23592

3420091

3420092

3420093

3420094

3420095

3420096

3420097

3420098

3420099

3420100

3420101

3420102

3420103

3420116

3420120

3420121

3420128

3420129

3420130

3420131

3420132

3420134

3420136

3420137

3420139

3420140

3420141

3420142

54159_at

72884_at

7956842

A_14_P121448

A_23_P151018

A_33_P3382709

GE58578

GO:0003674

GO:0003676

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005637

GO:0005639

GO:0006997

GO:0006998

GO:0007165

GO:0008150

GO:0009058

GO:0016020

GO:0016021

GO:0030512

GO:0030514

GO:0031965

GO:0032926

GO:0034641

GO:0043226

GO:0061024

GO:1902531

ILMN_1727361

ILMN_2183938

PH_hs_0029077

TC12000581.hg

g7706606_3p_at

Participant Of

hasCandidate

EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope]

Inferred To

Lemd3 [nuclear envelope] (Mus musculus)

Lemd3 [nuclear envelope] (Rattus norvegicus)

LEMD3 [nuclear envelope] (Bos taurus)

LEMD3 [nuclear envelope] (Canis familiaris)

LEMD3 [nuclear envelope] (Sus scrofa)

lemd3 [nuclear envelope] (Xenopus tropicalis)

Cross References

RefSeq

NP_055134.2, NP_001161086.1

OpenTargets

ENSG00000174106

GeneCards

Q9Y2U8

HPA

ENSG00000174106-LEMD3

Ensembl

ENST00000308330, ENSG00000174106, ENSP00000308369

PRO

Q9Y2U8

Orphanet

16349

PDB

5ZOJ, 2CH0, 5ZOK

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P84022 SMAD3	21	p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) SMAD3 [nucleoplasm] (R-HSA-206150) SMAD3 [cytosol] (R-HSA-170855) p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184)	0.564	2
UniProt:Q8BUN5 Smad3	7	phospho-Smad3 [nucleoplasm] (R-MMU-2187326) Smad3 [cytosol] (R-MMU-6782830) phospho-Smad3 [nucleoplasm] (R-MMU-2176471) Smad3 [nucleoplasm] (R-MMU-206150) Smad3 [cytosol] (R-MMU-170855) p-S423,425-Smad3 [cytosol] (R-MMU-9605416) p-S423,425-Smad3 [nucleoplasm] (R-MMU-1225907)	0.564	2
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.462	3
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) LMNA(1-664) [nucleoplasm] (R-HSA-535479) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537)	0.462	4