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SIN3B [nucleoplasm]
Stable Identifier
R-HSA-3006450
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Paired amphipathic helix protein Sin3b, SIN3B_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA (Homo sapiens)
NoRC:pRNA:HDAC:DNMT [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
SIN3 HDAC corepressor complex [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1 binds SIN3A,(SIN3B) co-repressor (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] (Homo sapiens)
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
SIN3B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75182 SIN3B
Gene Names
SIN3B, KIAA0700
Chain
chain:1-1162
Reference Genes
BioGPS Gene:23309 SIN3B
COSMIC (genes):SIN3B SIN3B
CTD Gene:23309 SIN3B
dbSNP Gene:23309 SIN3B
ENSEMBL:ENSG00000127511 SIN3B
ENSEMBL_homo_sapiens_GENE:ENSG00000127511.10 SIN3B
HGNC:19354 SIN3B
KEGG Gene (Homo sapiens):23309 SIN3B
Monarch:23309 SIN3B
NCBI Gene:23309 SIN3B
OMIM:607777 SIN3B
UCSC:O75182 SIN3B
Reference Transcript
RefSeq:NM_015260.3 SIN3B
RefSeq:NM_001297597.1 SIN3B
RefSeq:NM_001297595.1 SIN3B
Other Identifiers
11716810_a_at
11716811_s_at
11716812_x_at
11744734_a_at
11746239_a_at
11759689_at
16859368
209352_3p_s_at
209352_PM_s_at
209352_s_at
23309
3823902
3823903
3823904
3823905
3823908
3823909
3823910
3823911
3823914
3823916
3823918
3823919
3823920
3823921
3823922
3823923
3823924
3823925
3823929
3823931
3823932
3823933
3823935
3823938
3823939
3823940
3823943
3823944
3823945
3823946
3823947
3823952
39705_PM_at
39705_at
4881944_3p_s_at
8026610
90024_at
A_24_P93901
A_33_P3225230
GE53400
GE625594
GE84153
GE85101
GO:0000122
GO:0000228
GO:0000785
GO:0000805
GO:0000806
GO:0001741
GO:0003682
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0030336
GO:0030849
GO:0043226
GO:0045892
GO:0048870
GO:0070822
GO:0140110
HMNXSV003024979
Hs.13999.0.S1_3p_a_at
Hs.13999.0.S1_3p_s_at
ILMN_1788315
PH_hs_0001342
PH_hs_0041062
TC19000325.hg
Participates
as a candidate of
SIN3A,(SIN3B) [nucleoplasm] (Homo sapiens)
Inferred To
Sin3A [nucleoplasm]
(Drosophila melanogaster)
pst3 [nucleoplasm]
(Schizosaccharomyces pombe)
SIN3 [nucleoplasm]
(Saccharomyces cerevisiae)
SIN3B [nucleoplasm]
(Bos taurus)
SIN3B [nucleoplasm]
(Canis familiaris)
SIN3B [nucleoplasm]
(Gallus gallus)
SIN3B [nucleoplasm]
(Sus scrofa)
SIN3B-1 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of SIN3B-1 [nucleoplasm]
(Schizosaccharomyces pombe)
sin3b [nucleoplasm]
(Danio rerio)
sin3b [nucleoplasm]
(Xenopus tropicalis)
pst1 [nucleoplasm]
(Schizosaccharomyces pombe)
sin-3 [nucleoplasm]
(Caenorhabditis elegans)
Sin3b [nucleoplasm]
(Mus musculus)
Sin3b [nucleoplasm]
(Rattus norvegicus)
pst2 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_056075.1
,
NP_001284526.1
,
NP_001284524.1
OpenTargets
ENSG00000127511
HPA
ENSG00000127511-SIN3B
GeneCards
O75182
Ensembl
ENST00000596802
,
ENST00000379803
,
ENSP00000248054
,
ENSG00000127511
,
ENSP00000473039
,
ENST00000248054
,
ENSP00000369131
PRO
O75182
Pharos - Targets
O75182
PDB
8C60
,
8BPA
,
8BPB
,
8BPC
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.788
7
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.643
5
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.643
5
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.643
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.607
7
UniProt:Q96ST3 SIN3A
2
SIN3A [nucleoplasm]
(R-HSA-351657)
monoSUMO1-SIN3A [nucleoplasm]
(R-HSA-4086071)
0.527
2
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