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p-Y-PLXNA4 [plasma membrane]
Stable Identifier
R-HSA-419608
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
phosphorylated Plexin-A4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
CRMPs in Sema3A signaling (Homo sapiens)
Tyrosine phosphorylation of CRMPs by Fes (Homo sapiens)
Sema3A:NP-1:Plexin-A:Fes:CRMP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Inactivation of R-Ras by Sema3A-Plexin-A GAP activity (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Phosphorylation of Plexin-A (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Rac1 binds PlexinA (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Recruitment of Rnd1 to Plexin A (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Sema3A PAK dependent Axon repulsion (Homo sapiens)
Activation of PAK by Rac1 (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
Phosphorylation of LIMK-1 by PAK (Homo sapiens)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:pPAK [plasma membrane] (Homo sapiens)
Sema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:Fyn:Fes [plasma membrane] (Homo sapiens)
Sema3A:NRP-1:pPlexin-A:fyn [plasma membrane] (Homo sapiens)
NRP1:p-Plexin-A1-4:FYN [plasma membrane] (Homo sapiens)
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
p-Y-PLXNA4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCM2 PLXNA4
Gene Names
PLXNA4, KIAA1550, PLXNA4A, PLXNA4B, UNQ2820/PRO34003
Chain
signal peptide:1-23, chain:24-1894
Reference Genes
BioGPS Gene:91584 Q9HCM23
COSMIC - genes:PLXNA4 PLXNA4
CTD Gene:91584 Q9HCM23
dbSNP Gene:91584 PLXNA4
ENSEMBL:ENSG00000221866 PLXNA4
HGNC:9102 Q9HCM23
KEGG:hsa:91584 Q9HCM23
Monarch:91584 Q9HCM23
NCBI Gene:91584 Q9HCM23
OMIM:604280 Q9HCM23
UCSC:Q9HCM2 Q9HCM23
Reference Transcript
RefSeq:XM_006716171.5 Q9HCM23
RefSeq:NM_020911.2 Q9HCM23
RefSeq:XM_047421017.1 Q9HCM23
RefSeq:XM_054359309.1 Q9HCM23
RefSeq:NM_001393897.1 Q9HCM23
RefSeq:XM_054359308.1 Q9HCM23
RefSeq:NM_181775.4 Q9HCM23
RefSeq:NM_001105543.2 Q9HCM23
RefSeq:XM_047421019.1 Q9HCM23
RefSeq:XM_054359312.1 Q9HCM23
Participates
as a member of
p-Plexin-A1-4 [plasma membrane] (Homo sapiens)
Other forms of this molecule
PLXNA4 [plasma membrane]
Inferred To
phospho-plxna4 [plasma membrane]
(Danio rerio)
phospho-plxna4 [plasma membrane]
(Xenopus tropicalis)
phospho-Plxna4 [plasma membrane]
(Mus musculus)
phospho-Plxna4 [plasma membrane]
(Rattus norvegicus)
phospho-PLXNA4 [plasma membrane]
(Bos taurus)
phospho-PLXNA4 [plasma membrane]
(Canis familiaris)
phospho-PLXNA4 [plasma membrane]
(Gallus gallus)
phospho-PLXNA4 [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_054215287.1
,
XP_047276975.1
,
NP_001380826.1
,
XP_054215284.1
,
XP_054215283.1
,
NP_065962.1
,
NP_001099013.1
,
NP_861440.2
,
XP_006716234.1
,
XP_047276973.1
OpenTargets
ENSG00000221866
ENSEMBL
ENSG00000221866
,
ENSP00000367800
,
ENST00000378539
,
ENST00000423507
,
ENST00000359827
,
ENST00000321063
,
ENSP00000352882
,
ENSP00000323194
,
ENSP00000392772
HPA
ENSG00000221866-PLXNA4
GeneCards
PLXNA4
PRO
Q9HCM2
Pharos - Targets
Q9HCM2
GlyGen
Q9HCM2
PDB
4E74
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95825 QORL1
0.564
2
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.558
2
UniProt:Q06481 APLP2
4
APLP2 [endoplasmic reticulum lumen]
(R-HSA-8956784)
p-APLP2 [endoplasmic reticulum lumen]
(R-HSA-8956977)
APLP2 [platelet alpha granule membrane]
(R-HSA-8848898)
APLP2 [plasma membrane]
(R-HSA-8848902)
0.558
2
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