Reactome | HERC5 [cytosol]

HERC5 [cytosol]

Stable Identifier

R-HSA-936553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CEB1, Probable E3 ubiquitin-protein ligase HERC5, HERC5_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - RSV-host interactions (Homo sapiens)
        
        ISGylation of BECN1 (Homo sapiens)
        
        ISG15 E3 ligases [cytosol] (Homo sapiens)
        
        HERC5 [cytosol] (Homo sapiens)
        
        ISG15:UBCH8:ISG15 E3 ligase [cytosol] (Homo sapiens)
        
        ISG15 E3 ligases [cytosol] (Homo sapiens)
        
        HERC5 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UII4 HERC5

Gene Names

HERC5, CEB1, CEBP1

Chain

chain:1-1024

Reference Genes

BioGPS Gene:51191 HERC5

COSMIC (genes):HERC5 HERC5

CTD Gene:51191 HERC5

dbSNP Gene:51191 HERC5

ENSEMBL:ENSG00000138646 HERC5

HGNC:24368 HERC5

KEGG:hsa:51191 HERC5

Monarch:51191 HERC5

NCBI Gene:51191 HERC5

OMIM:608242 HERC5

UCSC:Q9UII4 HERC5

Reference Transcript

RefSeq:NM_016323.3 HERC5

Other Identifiers

11755374_a_at

16968765

219863_PM_at

219863_at

2735410

2735411

2735412

2735413

2735414

2735415

2735416

2735417

2735418

2735419

2735420

2735421

2735422

2735423

2735424

2735425

2735426

2735427

2735428

2735429

2735430

2735431

2735432

2735433

2735434

2735435

2735436

2735437

2735438

2735439

2735440

2735441

2735442

2735443

2735444

51191

61371_at

8096361

A_23_P110196

GE53687

GO:0000079

GO:0000209

GO:0002376

GO:0003723

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0006511

GO:0016567

GO:0016740

GO:0032020

GO:0039585

GO:0042296

GO:0045087

GO:0048471

GO:0050688

GO:0051607

GO:0061630

GO:0098542

GO:0140096

HMNXSV003027708

ILMN_1729749

PH_hs_0002353

TC04000485.hg

g7705930_3p_at

Participates

as a component of

ISG15:UBEIL/UbcH8:CEB1 [cytosol] (Homo sapiens)

as a member of

Inferred To

herc-1 [cytosol] (Caenorhabditis elegans)

HERC5 [cytosol] (Bos taurus)

HERC5 [cytosol] (Canis familiaris)

HERC5 [cytosol] (Dictyostelium discoideum)

HERC5 [cytosol] (Gallus gallus)

HERC5 [cytosol] (Plasmodium falciparum)

HERC5 [cytosol] (Sus scrofa)

Homologues of HERC5 [cytosol] (Caenorhabditis elegans)

Homologues of HERC5 [cytosol] (Dictyostelium discoideum)

gacGG [cytosol] (Dictyostelium discoideum)

glo-4 [cytosol] (Caenorhabditis elegans)

tirA [cytosol] (Dictyostelium discoideum)

Herc4 [cytosol] (Drosophila melanogaster)

herc4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_057407.2

ENSEMBL

ENSP00000264350, ENST00000264350

OpenTargets

ENSG00000138646

HPA

ENSG00000138646-HERC5

PRO

Q9UII4

Pharos - Targets

Q9UII4

GlyGen

Q9UII4

PDB

8Y4Z

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	3
UniProt:Q9P031 CCDC59	1	CCDC59 [nucleoplasm] (R-HSA-5683813)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	2