Reactome | SRRM1 [nucleoplasm]

SRRM1 [nucleoplasm]

Stable Identifier

R-HSA-156781

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SRm160

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        SRRM1 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        SRRM1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IYB3 SRRM1

Gene Names

SRRM1, SRM160

Chain

chain:1-904

Reference Genes

BioGPS Gene:10250 SRRM1

COSMIC (genes):SRRM1 SRRM1

CTD Gene:10250 SRRM1

dbSNP Gene:10250 SRRM1

ENSEMBL:ENSG00000133226 SRRM1

HGNC:16638 SRRM1

KEGG:hsa:10250 SRRM1

Monarch:10250 SRRM1

NCBI Gene:10250 SRRM1

OMIM:605975 SRRM1

UCSC:Q8IYB3 SRRM1

Reference Transcript

Other Identifiers

10250

11718775_a_at

11718776_s_at

11718777_at

11745984_a_at

11745985_s_at

11746679_a_at

11758235_s_at

16660828

201224_PM_s_at

201224_s_at

201225_PM_s_at

201225_s_at

2325527

2325528

2325529

2325530

2325531

2325532

2325533

2325536

2325537

2325538

2325539

2325540

2325541

2325542

2325543

2325544

2325545

2325546

2325547

2325548

2325549

2325550

2325551

2325552

2325553

2325554

2325555

2325556

2325557

2325558

2325559

2325560

2325562

2325563

2325564

2325565

2325566

2325567

2325568

2325569

2325572

2325573

2325574

2325575

2325576

2325577

2325578

2325579

2325580

2325581

2325582

2325583

2325584

2325585

2325586

3115345

3152679

3152682

3152684

3152685

4023615

4023616

4023626

4023627

41737_at

72692_r_at

7898975

85257_at

A_14_P121494

A_24_P11131

A_24_P264192

A_24_P679409

GE54421

GO:0000375

GO:0000398

GO:0003677

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006397

GO:0008380

GO:0016071

GO:0016363

GO:0016607

GO:0043226

GO:0048024

GO:0071013

HMNXSV003018893

HMNXSV003022025

HMNXSV003049441

Hs.18192.0.A1_3p_a_at

ILMN_1697670

PH_hs_0040525

TC01000313.hg

g5032118_3p_a_at

Participates

as an input of

Formation of the Spliceosomal Pre-B complex (Homo sapiens)

as a component of

Other forms of this molecule

SRRM1 [cytosol]

Inferred To

Ghost homologue of SRRM1 [nucleoplasm] (Danio rerio)

Ghost homologue of SRRM1 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of SRRM1 [nucleoplasm] (Xenopus tropicalis)

Srrm1 [nucleoplasm] (Drosophila melanogaster)

Srrm1 [nucleoplasm] (Mus musculus)

Srrm1 [nucleoplasm] (Rattus norvegicus)

SRRM1 [nucleoplasm] (Bos taurus)

SRRM1 [nucleoplasm] (Canis familiaris)

SRRM1 [nucleoplasm] (Dictyostelium discoideum)

SRRM1 [nucleoplasm] (Gallus gallus)

SRRM1 [nucleoplasm] (Plasmodium falciparum)

SRRM1 [nucleoplasm] (Sus scrofa)

JIP4 [nucleoplasm] (Saccharomyces cerevisiae)

rsr-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005830.2, NP_001290378.1, NP_001290377.1

ENSEMBL

ENSP00000326261, ENST00000323848

OpenTargets

ENSG00000133226

HPA

ENSG00000133226-SRRM1

PRO

Q8IYB3

Pharos - Targets

Q8IYB3

GlyGen

Q8IYB3

PDB

6FF7, 1MP1, 7ABG, 6FF4, 7DVQ, 7ABI, 7ABH

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.758	4
UniProt:P49760 CLK2			0.718	6
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.702	4
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.564	2
UniProt:P49760-3 CLK2			0.556	3
UniProt:A7MD48 SRRM4			0.556	3
UniProt:O95758 PTBP3			0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2