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SRPK2 [cytosol]
Stable Identifier
R-HSA-9729332
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SRSF protein kinase 2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of nucleoprotein (Homo sapiens)
SRPK1/2 phosphorylates nucleoprotein (Homo sapiens)
SRPK1/2 [cytosol] (Homo sapiens)
SRPK2:Mg2+ [cytosol] (Homo sapiens)
SRPK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78362 SRPK2
Gene Names
SRPK2
Chain
chain:1-688, chain:1-139, chain:140-688
Reference Genes
BioGPS Gene:6733 SRPK2
COSMIC (genes):SRPK2 SRPK2
CTD Gene:6733 SRPK2
dbSNP Gene:6733 SRPK2
ENSEMBL:ENSG00000135250 SRPK2
ENSEMBL_homo_sapiens_GENE:ENSG00000135250.17 SRPK2
HGNC:11306 SRPK2
KEGG Gene (Homo sapiens):6733 SRPK2
Monarch:6733 SRPK2
NCBI Gene:6733 SRPK2
OMIM:602980 SRPK2
UCSC:P78362 SRPK2
Reference Transcript
RefSeq:NM_182691.2 SRPK2
RefSeq:NM_001278273.1 SRPK2
RefSeq:NM_182692.2 SRPK2
RefSeq:XM_017012566.1 SRPK2
Other Identifiers
11721820_a_at
11721821_a_at
11754831_a_at
1213_at
1558254_PM_s_at
1558254_s_at
17061433
203181_PM_x_at
203181_x_at
203182_PM_s_at
203182_s_at
214931_PM_s_at
214931_s_at
230091_PM_at
230091_at
3066301
3066302
3066303
3066304
3066305
3066306
3066307
3066308
3066309
3066318
3066319
3066323
3066324
3066325
3066330
3066331
3066333
3066334
3066335
3066343
3066344
3066350
3066351
3066352
3066353
3066362
3066363
3066374
3066375
3066376
3066377
3066381
3066382
3066400
3066401
3100869
3100873
3137849
37409_at
6733
8142036
91778_s_at
A_23_P215599
A_23_P406438
GE59523
GO:0000166
GO:0000245
GO:0000287
GO:0000785
GO:0001525
GO:0002376
GO:0003723
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006325
GO:0006397
GO:0006468
GO:0008284
GO:0008380
GO:0010628
GO:0012501
GO:0016071
GO:0016301
GO:0016310
GO:0016607
GO:0016740
GO:0018105
GO:0023052
GO:0030154
GO:0035063
GO:0035556
GO:0036211
GO:0043226
GO:0043525
GO:0045070
GO:0045071
GO:0045087
GO:0045787
GO:0048024
GO:0048856
GO:0050684
GO:0062176
GO:0065003
GO:0071889
GO:0098542
GO:0106310
GO:0140096
Hs.78353.0.A1_3p_a_at
Hs.78353.1.A1_3p_at
Hs.78353.2.A1_3p_a_at
Hs2.380021.1.S1_3p_s_at
ILMN_1657451
ILMN_1669215
ILMN_1695468
PH_hs_0023115
TC07001731.hg
U88666_at
g4507220_3p_a_at
Participates
as a component of
SRPK2:Mg2+ [cytosol] (Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 52
Coordinate
52
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 588
Coordinate
588
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_872634.1
,
XP_016868055.1
,
NP_001265202.1
,
NP_872633.1
ZINC - World Drugs
SRPK2_HUMAN
Guide to Pharmacology - Targets
2209
OpenTargets
ENSG00000135250
ZINC - FDA approved
SRPK2_HUMAN
ZINC - Substances
SRPK2_HUMAN
ZINC - Biogenic
SRPK2_HUMAN
ZINC target
P78362
PRO
P78362
PDB
5MYV
,
2X7G
,
7ZKX
ZINC - Investigational
SRPK2_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000135250-SRPK2
GeneCards
P78362
Ensembl
ENST00000489828
,
ENSP00000377262
,
ENSP00000419791
,
ENST00000393651
,
ENSG00000135250
,
ENST00000357311
,
ENSP00000349863
Pharos - Targets
P78362
ZINC - Predictions - Purchasable
SRPK2_HUMAN
HMDB Protein
HMDBP08814
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.908
12
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.855
7
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.837
8
UniProt:P26368 U2AF2
2
5OHK15,276-U2AF2 [nucleoplasm]
(R-HSA-9630011)
U2AF2 [nucleoplasm]
(R-HSA-71987)
0.803
8
UniProt:Q8WVK2 SNRNP27
1
SNRNP27 [nucleoplasm]
(R-HSA-6806778)
0.754
5
UniProt:Q8IYB3 SRRM1
2
SRRM1 [nucleoplasm]
(R-HSA-156781)
SRRM1 [cytosol]
(R-HSA-159255)
0.702
4
UniProt:Q13243 SRSF5
1
SRSF5 [nucleoplasm]
(R-HSA-72028)
0.688
4
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.659
3
UniProt:Q13247 SRSF6
1
SRSF6 [nucleoplasm]
(R-HSA-72026)
0.643
4
UniProt:Q13523 PRPF4B
1
PRPF4B [nucleoplasm]
(R-HSA-9769525)
0.643
3
UniProt:Q9UQ35 SRRM2
1
SRRM2 [nucleoplasm]
(R-HSA-8865888)
0.643
3
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.642
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.613
3
UniProt:Q9Y3Y2 CHTOP
1
CHTOP [nucleoplasm]
(R-HSA-8849147)
0.59
2
UniProt:P50613 CDK7
1
CDK7 [nucleoplasm]
(R-HSA-69218)
0.59
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.59
2
UniProt:Q9H0G5 NSRP1
1
NSRP1 [nucleoplasm]
(R-HSA-9770428)
0.59
2
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.59
2
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.59
2
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.59
2
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.59
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.553
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.547
2
UniProt:Q9Y3T9 NOC2L
1
NOC2L [nucleoplasm]
(R-HSA-3222129)
0.527
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q9UDY2 TJP2
4
TJP2 [plasma membrane]
(R-HSA-351862)
TJP2(?-?) [plasma membrane]
(R-HSA-351897)
TJP2 [cytosol]
(R-HSA-2064412)
TJP2 [nucleoplasm]
(R-HSA-2064410)
0.527
2
UniProt:Q01130 SRSF2
1
SRSF2 [nucleoplasm]
(R-HSA-72033)
0.527
2
UniProt:Q9Y221 NIP7
1
NIP7 [nucleoplasm]
(R-HSA-6797236)
0.527
2
UniProt:Q14966 ZNF638
1
ZNF638 [nucleoplasm]
(R-HSA-8939429)
0.527
2
UniProt:O95232 LUC7L3
1
LUC7L3 [nucleoplasm]
(R-HSA-9770258)
0.527
2
UniProt:Q05519 SRSF11
1
SRSF11 [nucleoplasm]
(R-HSA-72058)
0.527
2
UniProt:O43159 RRP8
1
RRP8 [nucleoplasm]
(R-HSA-427524)
0.527
2
UniProt:Q9NW13 RBM28
1
RBM28 [nucleoplasm]
(R-HSA-6791192)
0.527
2
UniProt:Q8IY81 FTSJ3
1
FTSJ3 [nucleoplasm]
(R-HSA-6791507)
0.527
2
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.527
2
UniProt:P46087 NOP2
1
NOP2 [nucleoplasm]
(R-HSA-6790922)
0.527
2
UniProt:P62306 SNRPF
2
SNRPF [nucleoplasm]
(R-HSA-71907)
SNRPF [cytosol]
(R-HSA-191852)
0.527
2
UniProt:O43143 DHX15
1
DHX15 [nucleoplasm]
(R-HSA-5688097)
0.527
2
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.525
2
UniProt:Q86UR5 RIMS1
1
RIMS1 [cytosol]
(R-HSA-210407)
0.499
3
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.483
2
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