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RNPS1 [cytosol]
Stable Identifier
R-HSA-159256
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Regulation of expression of SLITs and ROBOs (Homo sapiens)
Translation of ROBO3.2 mRNA initiates NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
Translation of ROBO3.2 mRNA is negatively regulated by NMD (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
Translated ROBO3.2 mRNA in complex with NMD-initiating UPF2 [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
RNPS1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15287 RNPS1
Gene Names
RNPS1, LDC2
Chain
chain:1-305
Reference Genes
BioGPS Gene:10921 RNPS1
COSMIC (genes):RNPS1 RNPS1
CTD Gene:10921 RNPS1
dbSNP Gene:10921 RNPS1
ENSEMBL:ENSG00000205937 RNPS1
HGNC:10080 RNPS1
KEGG:hsa:10921 RNPS1
Monarch:10921 RNPS1
NCBI Gene:10921 RNPS1
OMIM:606447 RNPS1
UCSC:Q15287 RNPS1
Reference Transcript
RefSeq:NM_006711.4 RNPS1
RefSeq:NM_001286625.1 RNPS1
RefSeq:NM_001286627.1 RNPS1
RefSeq:NM_001286626.1 RNPS1
RefSeq:XM_005255049.3 RNPS1
RefSeq:XM_017022874.1 RNPS1
RefSeq:XM_005255048.1 RNPS1
RefSeq:NM_080594.3 RNPS1
Participates
as a component of
Exon Junction:UPF2:UPF3 Complex [cytosol] (Homo sapiens)
EJC [cytosol] (Homo sapiens)
Other forms of this molecule
RNPS1 [nucleoplasm]
Inferred To
rnp-5 [cytosol]
(Caenorhabditis elegans)
RNPS1 [cytosol]
(Bos taurus)
RNPS1 [cytosol]
(Canis familiaris)
RNPS1 [cytosol]
(Dictyostelium discoideum)
RNPS1 [cytosol]
(Gallus gallus)
RNPS1 [cytosol]
(Plasmodium falciparum)
RNPS1 [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of RNPS1 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of RNPS1 [cytosol]
(Sus scrofa)
RnpS1 [cytosol]
(Drosophila melanogaster)
Rnps1 [cytosol]
(Mus musculus)
Rnps1 [cytosol]
(Rattus norvegicus)
rnps1 [cytosol]
(Danio rerio)
rnps1 [cytosol]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000205937
ENSEMBL
ENSG00000205937
,
ENSP00000301730
,
ENSP00000457723
,
ENSP00000457820
,
ENSP00000456352
,
ENSP00000380275
,
ENST00000565678
,
ENST00000320225
,
ENSP00000315859
,
ENST00000397086
,
ENST00000566458
,
ENST00000568631
,
ENST00000301730
GeneCards
RNPS1
HPA
ENSG00000205937-RNPS1
PRO
Q15287
Pharos - Targets
Q15287
GlyGen
Q15287
PDB
4A8X
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08170 SRSF4
1
SRSF4 [nucleoplasm]
(R-HSA-72024)
0.678
3
UniProt:Q13523 PRPF4B
1
PRPF4B [nucleoplasm]
(R-HSA-9769525)
0.669
4
UniProt:P26368 U2AF2
2
U2AF2 [nucleoplasm]
(R-HSA-71987)
5OHK15,276-U2AF2 [nucleoplasm]
(R-HSA-9630011)
0.669
5
UniProt:Q8IYB3 SRRM1
2
SRRM1 [cytosol]
(R-HSA-159255)
SRRM1 [nucleoplasm]
(R-HSA-156781)
0.669
3
UniProt:Q16629 SRSF7
1
SRSF7 [nucleoplasm]
(R-HSA-72029)
0.666
4
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.665
3
UniProt:Q9BZI7 UPF3B
2
UPF3B [cytosol]
(R-HSA-159258)
UPF3B [nucleoplasm]
(R-HSA-156776)
0.643
3
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.589
2
UniProt:Q05519 SRSF11
1
SRSF11 [nucleoplasm]
(R-HSA-72058)
0.564
2
UniProt:Q92620 DHX38
1
DHX38 [nucleoplasm]
(R-HSA-72060)
0.564
2
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.564
2
UniProt:O94906 PRPF6
1
PRPF6 [nucleoplasm]
(R-HSA-71881)
0.564
2
UniProt:O75400 PRPF40A
1
PRPF40A [nucleoplasm]
(R-HSA-8867890)
0.564
2
UniProt:Q13427 PPIG
2
PPIG [nucleoplasm]
(R-HSA-9769592)
PPIG [cytosol]
(R-HSA-9728768)
0.564
3
UniProt:Q8N5F7 NKAP
1
NKAP [nucleoplasm]
(R-HSA-9769602)
0.564
3
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.564
3
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.564
2
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.558
4
UniProt:Q13242 SRSF9
1
SRSF9 [nucleoplasm]
(R-HSA-72037)
0.556
3
UniProt:P84103 SRSF3
1
SRSF3 [nucleoplasm]
(R-HSA-72035)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q96MU7 YTHDC1
1
YTHDC1 [nucleoplasm]
(R-HSA-9935812)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.547
3
UniProt:Q13247 SRSF6
1
SRSF6 [nucleoplasm]
(R-HSA-72026)
0.547
3
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.527
3
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.527
3
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.527
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.527
3
UniProt:O15234 CASC3
2
CASC3 [nucleoplasm]
(R-HSA-8849148)
CASC3 [cytosol]
(R-HSA-927807)
0.527
3
UniProt:O75152 ZC3H11A
1
ZC3H11A [nucleoplasm]
(R-HSA-8850659)
0.483
2
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