Reactome | UQCRC1 [mitochondrial inner membrane]

UQCRC1 [mitochondrial inner membrane]

Stable Identifier

R-HSA-164284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ubiquinol-cytochrome-c reductase complex core protein I, Complex III core protein I

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P31930 UQCRC1

Gene Names

UQCRC1

Chain

transit peptide:1-34, chain:35-480

Reference Genes

BioGPS Gene:7384 UQCRC1

COSMIC (genes):UQCRC1 UQCRC1

CTD Gene:7384 UQCRC1

dbSNP Gene:7384 UQCRC1

ENSEMBL:ENSG00000010256 UQCRC1

HGNC:12585 UQCRC1

KEGG:hsa:7384 UQCRC1

Monarch:7384 UQCRC1

NCBI Gene:7384 UQCRC1

OMIM:191328 UQCRC1

UCSC:P31930 UQCRC1

Reference Transcript

RefSeq:NM_003365.2 UQCRC1

Other Identifiers

11743979_a_at

11747855_a_at

11761061_at

16953568

201903_PM_at

201903_at

2673510

2673511

2673512

2673513

2673514

2673515

2673516

2673517

2673518

2673519

2673520

2673521

2673522

2673523

2673524

2673525

2673526

2673527

2673528

2673529

2673530

2673531

2673532

2673533

2673534

2673535

2673536

283_at

7384

8087100

A_23_P132675

GE57651

GO:0003824

GO:0005215

GO:0005515

GO:0005739

GO:0005743

GO:0006091

GO:0006119

GO:0006122

GO:0008121

GO:0009060

GO:0014823

GO:0016491

GO:0031625

GO:0043226

GO:0043279

GO:0044877

GO:0045275

GO:0045333

GO:0046872

GO:0055085

GO:0098803

GO:1902600

HMNXSV003052550

ILMN_1671191

L16842_at

PH_hs_0027224

TC03001384.hg

g4507840_3p_at

Participates

as an input of

Intermediate II binds CYC1, UQCRC1, UQCRC2, UQCRH (Homo sapiens)

as a component of

Inferred To

UQCR-C1 [mitochondrial inner membrane] (Drosophila melanogaster)

UQCRC1 [mitochondrial inner membrane] (Bos taurus)

UQCRC1 [mitochondrial inner membrane] (Caenorhabditis elegans)

UQCRC1 [mitochondrial inner membrane] (Dictyostelium discoideum)

UQCRC1 [mitochondrial inner membrane] (Gallus gallus)

UQCRC1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

UQCRC1 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

UQCRC1 [mitochondrial inner membrane] (Sus scrofa)

ucr-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Uqcrc1 [mitochondrial inner membrane] (Mus musculus)

Uqcrc1 [mitochondrial inner membrane] (Rattus norvegicus)

uqcrc1 [mitochondrial inner membrane] (Danio rerio)

COR1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Homologues of UQCRC1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Homologues of UQCRC1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000010256

ENSEMBL

ENSP00000203407, ENST00000203407

HPA

ENSG00000010256-UQCRC1

PRO

P31930

Pharos - Targets

P31930

GlyGen

P31930

HMDB Protein

HMDBP00987

PDB

5XTH, 5XTI, 5XTE

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22695 UQCRC2	1	UQCRC2 [mitochondrial inner membrane] (R-HSA-164280)	0.688	4
UniProt:O14949 UQCRQ	1	UQCRQ [mitochondrial inner membrane] (R-HSA-164283)	0.669	4
UniProt:P14927 UQCRB	1	UQCRB [mitochondrial inner membrane] (R-HSA-164287)	0.669	5
UniProt:Q9UDW1 UQCR10	1	UQCR10 [mitochondrial inner membrane] (R-HSA-164282)	0.564	3
UniProt:O95947 TBX6	1	TBX6 [nucleoplasm] (R-HSA-9793377)	0.556	3
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:Q00169 PITPNA	1	PITPNA [cytosol] (R-HSA-418391)	0.556	3
UniProt:P26641 EEF1G	3	EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850) EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839) EEF1G [cytosol] (R-HSA-156925)	0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.556	3
UniProt:Q9BZM4 ULBP3	1	ULBP3 [plasma membrane] (R-HSA-198076)	0.556	3
UniProt:P52566 ARHGDIB	1	ARHGDIB [cytosol] (R-HSA-195081)	0.556	3
UniProt:O95416 SOX14			0.556	3
UniProt:Q9UFG5 CS025			0.556	3
UniProt:Q9BRT8 ZNG1A			0.556	3
IntAct:EBI-25895235 CCSB			0.556	3
UniProt:O43704 SULT1B1	1	SULT1B1 [cytosol] (R-HSA-176551)	0.556	3
UniProt:Q6ZMY6-2 Q6ZMY62			0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:Q8WU43 CB015			0.556	3
IntAct:EBI-25895034 CCSB			0.556	3
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.556	3
UniProt:Q9BUA3 SPNDC			0.556	3
UniProt:Q8IV13 CCNJL			0.556	3
UniProt:CCDC26 A0A024R9H7			0.556	3
UniProt:Q9UHV9 PFDN2	1	PFDN2 [cytosol] (R-HSA-379544)	0.556	3
UniProt:Q9P0T4 ZN581			0.556	3
UniProt:Q9HC44 GPBL1			0.556	3
UniProt:Q8N108-16 MIER1			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:Q9Y6G5 COMMD10	2	COMMD10 [nucleoplasm] (R-HSA-8955101) COMMD10 [cytosol] (R-HSA-8955105)	0.556	3
UniProt:Q8N8E2 ZN513			0.556	3
UniProt:C9J082 C9J082			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q96MN9-2 Q96MN92			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:P07919 UQCRH	1	UQCRH [mitochondrial inner membrane] (R-HSA-164286)	0.527	2
UniProt:P27105 STOM	4	STOM [azurophil granule membrane] (R-HSA-6800997) STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960)	0.508	2
UniProt:P35610 SOAT1	1	SOAT1 [endoplasmic reticulum membrane] (R-HSA-8876490)	0.508	2
UniProt:P13073 COX4I1	2	COX4I1 [mitochondrial intermembrane space] (R-HSA-9865413) COX4I1 [mitochondrial inner membrane] (R-HSA-164305)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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