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NGFR(251-427) [plasma membrane]
Stable Identifier
R-HSA-194476
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p75NTR cleaved of ectodomain, Tumor necrosis factor receptor superfamily member 16, TR16_HUMAN, NGFR
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
The p75NTR C-terminal fragment enters endosomes (Homo sapiens)
NGFR(251-427) [plasma membrane] (Homo sapiens)
alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)
NGFR(251-427) [plasma membrane] (Homo sapiens)
gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)
NGFR(251-427) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08138 NGFR
Gene Names
NGFR, TNFRSF16
Chain
signal peptide:1-28, chain:29-427
Reference Genes
BioGPS Gene:4804 NGFR
COSMIC (genes):NGFR NGFR
CTD Gene:4804 NGFR
dbSNP Gene:4804 NGFR
ENSEMBL:ENSG00000064300 NGFR
ENSEMBL_homo_sapiens_GENE:ENSG00000064300.9 NGFR
HGNC:7809 NGFR
KEGG Gene (Homo sapiens):4804 NGFR
Monarch:4804 NGFR
NCBI Gene:4804 NGFR
OMIM:162010 NGFR
UCSC:P08138 NGFR
Reference Transcript
RefSeq:NM_002507.3 NGFR
Other Identifiers
11723398_at
11747159_a_at
1673_at
16835592
205858_PM_at
205858_at
3725686
3725687
3725694
3725699
3725702
3725705
3725706
3725707
3725708
4804
8008201
A_23_P389897
GE57836
GO:0001540
GO:0001678
GO:0001942
GO:0004888
GO:0005035
GO:0005515
GO:0005516
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005911
GO:0006351
GO:0006355
GO:0006886
GO:0006915
GO:0006919
GO:0007165
GO:0007266
GO:0007399
GO:0007411
GO:0007417
GO:0007623
GO:0008543
GO:0009986
GO:0010468
GO:0012501
GO:0014069
GO:0015026
GO:0016020
GO:0016048
GO:0021675
GO:0023052
GO:0030154
GO:0030336
GO:0030426
GO:0031069
GO:0031267
GO:0031410
GO:0031594
GO:0031625
GO:0032922
GO:0035907
GO:0038023
GO:0040037
GO:0042475
GO:0042488
GO:0042593
GO:0042995
GO:0043121
GO:0043197
GO:0043204
GO:0043226
GO:0043588
GO:0045202
GO:0048144
GO:0048146
GO:0048406
GO:0048511
GO:0048856
GO:0048870
GO:0051402
GO:0051799
GO:0060089
GO:0098793
GO:0099171
GO:1900182
GO:1902895
GO:1903588
GO:1904646
GO:2001235
HMNXSV003023040
ILMN_1752658
M14764_at
PH_hs_0025025
TC17000645.hg
g4505392_3p_at
Participates
as an input of
gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)
The p75NTR C-terminal fragment enters endosomes (Homo sapiens)
as an output of
alpha-secretase cleaves the p75NTR extracellular domain (Homo sapiens)
Other forms of this molecule
NGFR [plasma membrane]
NGFR(29-250) [extracellular region]
NGFR(251-427) [endosome]
NGFR(273-427) [cytosol]
NGFR(251-272) [plasma membrane]
NGFR(273-427) [nucleoplasm]
Inferred To
NGFR [plasma membrane]
(Bos taurus)
NGFR [plasma membrane]
(Canis familiaris)
NGFR [plasma membrane]
(Gallus gallus)
NGFR [plasma membrane]
(Sus scrofa)
ngfr [plasma membrane]
(Xenopus tropicalis)
ngfrb [plasma membrane]
(Danio rerio)
Ngfr [plasma membrane]
(Mus musculus)
Ngfr [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_002498.1
Guide to Pharmacology - Targets
1888
OpenTargets
ENSG00000064300
GeneCards
P08138
HPA
ENSG00000064300-NGFR
ZINC - Substances
TNR16_HUMAN
ZINC target
P08138
Ensembl
ENST00000504201
,
ENSP00000421731
,
ENSP00000172229
,
ENST00000172229
,
ENSG00000064300
PRO
P08138
Pharos - Targets
P08138
ZINC - Predictions - Purchasable
TNR16_HUMAN
PDB
2N83
,
7CSQ
,
5ZGG
,
8X8T
,
2N97
,
3EWV
,
2N80
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9CPR8
1
Nsmce3 [nucleoplasm]
(R-MMU-2993761)
0.602
3
UniProt:P25233 NECD
0.602
3
UniProt:Q96FE5 LINGO1
1
LINGO1 [plasma membrane]
(R-HSA-3006563)
0.589
2
UniProt:Q9Y467 SALL2
0.581
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.558
2
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P33681 CD80
1
CD80 [plasma membrane]
(R-HSA-179789)
0.544
3
UniProt:P01138-PRO_0000019600 NGF
0.544
2
UniProt:P01138 NGF
7
NGF(19-241) [extracellular region]
(R-HSA-187033)
NGF [Golgi lumen]
(R-HSA-166515)
NGF [cytosol]
(R-HSA-190059)
NGF(1-241) [endoplasmic reticulum lumen]
(R-HSA-187026)
NGF(19-241) [Golgi lumen]
(R-HSA-187036)
NGF(19-241) [endoplasmic reticulum lumen]
(R-HSA-187047)
NGF [extracellular region]
(R-HSA-167034)
0.544
2
UniProt:O75509 TNFRSF21
1
TNFRSF21 [plasma membrane]
(R-HSA-561169)
0.544
4
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