Reactome | NGF [cytosol]

NGF [cytosol]

Stable Identifier

R-HSA-190059

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nerve Growth Factor, Neurotrophin

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Activation of TRKA receptors (Homo sapiens)
        
        TRKA activation by NGF (Homo sapiens)
        
        Activated TrkA receptor internalizes to endosomes (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        (Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
        
        Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Homo sapiens)
        
        Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        FRS2 binds to active TrkA receptor (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        Active TrkA receptor:FRS2 complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        FRS2 is phosphorylated by active TrkA receptor (Homo sapiens)
        
        Active TrkA receptor:FRS2 complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        p-FRS2 binds CRKL (Homo sapiens)
        
        Active TrkA receptor:p-FRS2 complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        p-FRS2:CRKL binds C3G (Homo sapiens)
        
        Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)
        
        Active TrkA receptor:p-FRS2:CRKL:RAPGEF1 [endosome membrane] (Homo sapiens)
        
        Active TrkA receptor:p-FRS2:CRKL complex [endosome membrane] (Homo sapiens)
        
        Activated TrkA receptor complex [endosome membrane] (Homo sapiens)
        
        beta-NGF homodimer [cytosol] (Homo sapiens)
        
        NGF [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01138 NGF

Gene Names

NGF, NGFB

Chain

signal peptide:1-18, propeptide:19-121, chain:122-241

Reference Genes

BioGPS Gene:4803 NGF

COSMIC (genes):NGF NGF

CTD Gene:4803 NGF

dbSNP Gene:4803 NGF

ENSEMBL:ENSG00000134259 NGF

HGNC:7808 NGF

KEGG:hsa:4803 NGF

Monarch:4803 NGF

NCBI Gene:4803 NGF

OMIM:162030 NGF

UCSC:P01138 NGF

Reference Transcript

Participates

as a component of

beta-NGF homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

NGF [extracellular region]

NGF(19-241) [endoplasmic reticulum lumen]

NGF(19-241) [Golgi lumen]

NGF(1-241) [endoplasmic reticulum lumen]

NGF [Golgi lumen]

NGF(19-241) [extracellular region]

Inferred To

NGF [cytosol] (Bos taurus)

NGF [cytosol] (Canis familiaris)

NGF [cytosol] (Gallus gallus)

NGF [cytosol] (Mus musculus)

NGF [cytosol] (Rattus norvegicus)

NGF [cytosol] (Sus scrofa)

ngf [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_006710726.1, NP_002497.2

OpenTargets

ENSG00000134259

ENSEMBL

ENSP00000502380, ENST00000680540, ENSP00000505694, ENSG00000134259, ENST00000675637, ENST00000676038, ENST00000679806, ENST00000680116, ENSP00000506492, ENSP00000358525, ENST00000680752, ENSP00000502831, ENSP00000505558, ENST00000369512, ENSP00000506569

ZINC - Substances

NGF_HUMAN

ZINC target

P01138

PRO

P01138

GlyGen

P01138

PDB

1SG1, 1WWW, 5JZ7, 4ZBN, 2IFG, 4EDW, 6YW8, 4EDX

HPA

ENSG00000134259-NGF

GeneCards

NGF

Pharos - Targets

P01138

Orphanet

NGF

HMDB Protein

HMDBP02581

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07174 Ngfr	8	Ngfr [nucleoplasm] (R-RNO-197473) Ngfr [extracellular region] (R-RNO-194470) Ngfr [endosome] (R-RNO-209541) Ngfr [plasma membrane] (R-RNO-194509) Ngfr [cytosol] (R-RNO-194458) Ngfr [plasma membrane] (R-RNO-194476) Tumor necrosis factor receptor superfamily member 16 [plasma membrane] (R-RNO-193863) Ngfr [plasma membrane] (R-RNO-193664)	0.722	3
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413) NTRK1 [plasma membrane] (R-HSA-3008784) NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810)	0.683	3
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.676	5
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	9
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.556	3
UniProt:P08138 NGFR	7	NGFR [plasma membrane] (R-HSA-193664) NGFR(251-427) [plasma membrane] (R-HSA-194476) NGFR(273-427) [cytosol] (R-HSA-194458) NGFR(251-272) [plasma membrane] (R-HSA-194509) NGFR(251-427) [endosome] (R-HSA-209541) NGFR(29-250) [extracellular region] (R-HSA-194470) NGFR(273-427) [nucleoplasm] (R-HSA-197473)	0.544	2

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