Reactome | PTN [extracellular region]

PTN [extracellular region]

Stable Identifier

R-HSA-201500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Pleiotrophin, PTN_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P21246 PTN

Gene Names

PTN, HBNF1, NEGF1

Chain

signal peptide:1-32, chain:33-168

Reference Genes

BioGPS Gene:5764 PTN

COSMIC (genes):PTN PTN

CTD Gene:5764 PTN

dbSNP Gene:5764 PTN

ENSEMBL:ENSG00000105894 PTN

HGNC:9630 PTN

Monarch:5764 PTN

NCBI Gene:5764 PTN

OMIM:162095 PTN

UCSC:P21246 PTN

Reference Transcript

Other Identifiers

11723961_s_at

11753666_x_at

17063254

209465_PM_x_at

209465_x_at

209466_PM_x_at

209466_x_at

211737_PM_x_at

211737_x_at

234_s_at

3074856

3074858

3074859

3074860

3074861

3074862

3074863

3074872

3074873

3074874

3074901

3074902

3074903

34820_at

45061_at

5764

8143144

A_23_P303087

GE490527

GE57981

GO:0001503

GO:0002232

GO:0002376

GO:0002690

GO:0004864

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005886

GO:0007165

GO:0007185

GO:0007229

GO:0007399

GO:0007406

GO:0007612

GO:0007613

GO:0008083

GO:0008201

GO:0008284

GO:0010594

GO:0010976

GO:0010996

GO:0019901

GO:0022414

GO:0030246

GO:0030282

GO:0030501

GO:0031104

GO:0031641

GO:0032991

GO:0035374

GO:0042246

GO:0043113

GO:0043226

GO:0043932

GO:0044849

GO:0045597

GO:0045778

GO:0046697

GO:0048018

GO:0048167

GO:0048477

GO:0048680

GO:0048714

GO:0048856

GO:0048870

GO:0050804

GO:0050877

GO:0051781

GO:0098685

GO:0098772

GO:0140059

GO:0140677

GO:1900006

GO:1900272

GO:1903706

GO:2000036

GO:2000347

GO:2000738

HMNXSV003024258

HMNXSV003045852

ILMN_1813753

M57399_at

PH_hs_0000005

TC07001895.hg

g292072_3p_s_at

Participates

as a member of

PTN,MDK [extracellular region] (Homo sapiens)

as a component of

as an input of

ALK binds ligand pleiotrophin (PTN) (Homo sapiens)

Inferred To

Ptn [extracellular region] (Mus musculus)

Pleiotrophin [extracellular region] (Rattus norvegicus)

ptn [extracellular region] (Danio rerio)

ptn [extracellular region] (Xenopus tropicalis)

PTN [extracellular region] (Bos taurus)

PTN [extracellular region] (Canis familiaris)

PTN [extracellular region] (Gallus gallus)

PTN [extracellular region] (Sus scrofa)

Cross References

ENSEMBL

ENST00000348225, ENSP00000341170

OpenTargets

ENSG00000105894

HPA

ENSG00000105894-PTN

PRO

P21246

Pharos - Targets

P21246

HMDB Protein

HMDBP02150

PDB

8VOI, 2N6F, 8VOH

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11215 ITGAM	3	ITGAM [plasma membrane] (R-HSA-202757) ITGAM [specific granule membrane] (R-HSA-6799647) ITGAM [tertiary granule membrane] (R-HSA-6800979)	0.618	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q12797-6 ASPH			0.556	3
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.556	3
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.556	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.553	2
UniProt:Q9NRR5 UBQL4			0.553	2
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.553	2
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.553	2
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.553	2

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