Reactome | RABGEF1 [early endosome membrane]

RABGEF1 [early endosome membrane]

Stable Identifier

R-HSA-2029032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

Rabex5, Rab5 GDP/GTP exchange factor, RABX5_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UJ41 RABGEF1

Gene Names

RABGEF1, RABEX5

Chain

chain:1-491

Reference Genes

BioGPS Gene:27342 RABGEF1

COSMIC (genes):RABGEF1 RABGEF1

CTD Gene:27342 RABGEF1

dbSNP Gene:27342 RABGEF1

ENSEMBL:ENSG00000154710 RABGEF1

HGNC:17676 RABGEF1

KEGG:hsa:27342 RABGEF1

Monarch:27342 RABGEF1

NCBI Gene:27342 RABGEF1

OMIM:609700 RABGEF1

UCSC:Q9UJ41 RABGEF1

Reference Transcript

Participates

as a component of

GGA1,2,3:RAB5:GTP:RABGEF1 [early endosome membrane] (Homo sapiens)

Other forms of this molecule

RABGEF1 [cytosol]

Inferred To

Rabex-5 [early endosome membrane] (Drosophila melanogaster)

rabgef1l [early endosome membrane] (Danio rerio)

RABGEF1 [early endosome membrane] (Sus scrofa)

rabx-5 [early endosome membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001354660.1, NP_001354662.1, NP_001273990.1, NP_001354661.1, NP_055319.1, NP_001354656.1, NP_001354657.1, NP_001273989.1, NP_001354665.1, NP_001354663.1, NP_001273991.1, NP_001354664.1, NP_001354655.1, NP_001354659.1, NP_001354654.1, NP_001354658.1

OpenTargets

ENSG00000154710

ENSEMBL

ENST00000284957, ENST00000450873, ENSP00000415815, ENSP00000284957, ENSG00000154710

HPA

ENSG00000154710-RABGEF1

GeneCards

RABGEF1

PRO

Q9UJ41

Pharos - Targets

Q9UJ41

GlyGen

Q9UJ41

PDB

2C7N, 1TXU, 4N3X, 4N3Y, 2C7M, 4N3Z, 2OT3, 4Q9U

HMDB Protein

HMDBP08515

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.806	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.749	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.643	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.632	6
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.599	4
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.527	2
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	2
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.527	2

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