Reactome | PFN1 [cytosol]

PFN1 [cytosol]

Stable Identifier

R-HSA-203081

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Profilin I

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External Reference Information

External Reference

UniProt:P07737 PFN1

Gene Names

PFN1

Chain

initiator methionine:, chain:2-140

Reference Genes

BioGPS Gene:5216 PFN1

COSMIC (genes):PFN1 PFN1

CTD Gene:5216 PFN1

dbSNP Gene:5216 PFN1

ENSEMBL:ENSG00000108518 PFN1

HGNC:8881 PFN1

KEGG:hsa:5216 PFN1

Monarch:5216 PFN1

NCBI Gene:5216 PFN1

OMIM:176610 PFN1

UCSC:P07737 PFN1

Reference Transcript

RefSeq:NM_005022.3 PFN1

Other Identifiers

11717574_s_at

11753722_x_at

16840155

200634_PM_at

200634_at

2443974

2443976

36675_r_at

3742401

3742402

3742403

3742404

3742405

3742406

3742408

3742409

3742410

3742411

3742413

5216

74991_r_at

8011759

A_23_P27096

GE564032

GO:0000774

GO:0001784

GO:0001843

GO:0003723

GO:0003779

GO:0003785

GO:0005515

GO:0005546

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0005938

GO:0006355

GO:0006357

GO:0007010

GO:0008092

GO:0008289

GO:0010634

GO:0016020

GO:0030036

GO:0030833

GO:0030837

GO:0030838

GO:0031267

GO:0032232

GO:0032233

GO:0032781

GO:0034330

GO:0043226

GO:0044087

GO:0045296

GO:0050804

GO:0050821

GO:0051497

GO:0060074

GO:0070062

GO:0070064

GO:0072562

GO:0098772

GO:0098885

GO:0098978

GO:0110053

GO:1900029

HMNXSV003022590

ILMN_1712950

ILMN_2151817

J03191_at

PH_hs_0030086

TC17001036.hg

g4826897_3p_at

g4826897_3p_x_at

Participates

as a member of

Platelet releasate (inferred) cytosolic proteins [cytosol] (Homo sapiens)

as a component of

ppDVL:DAAM1:PFN1 [cytosol] (Homo sapiens)

as an input of

DAAM1 recruits PFN1 (Homo sapiens)

as a candidate of

PFN [cytosol] (Homo sapiens)

Other forms of this molecule

PFN1 [extracellular region]

Inferred To

Homologues of PFN1 [cytosol] (Danio rerio)

pfn2b [cytosol] (Danio rerio)

pfn1 [cytosol] (Danio rerio)

PFN1 [cytosol] (Bos taurus)

PFN1 [cytosol] (Canis familiaris)

PFN1 [cytosol] (Sus scrofa)

Pfn1 [cytosol] (Mus musculus)

Pfn1 [cytosol] (Rattus norvegicus)

pfn2a [cytosol] (Danio rerio)

Cross References

RefSeq

NP_005013.1

OpenTargets

ENSG00000108518

ENSEMBL

ENSP00000225655, ENST00000225655

HPA

ENSG00000108518-PFN1

PRO

P07737

Pharos - Targets

P07737

Orphanet

PFN1

GlyGen

P07737

PDB

3CHW, 4X1L, 1CJF, 1CF0, 1FIL, 9AZP, 8RTY, 1AWI, 7P1H, 2PAV, 8BJI, 6NAS, 4X1M, 2PBD, 6NBE, 1PFL, 6NBW, 4X25, 1FIK, 8BJJ, 8BJH, 8BR0

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.693	3
UniProt:Q92558 WASF1	3	WASF1 [cytosol] (R-HSA-200965) p-Y151-WASF1 [cytosol] (R-HSA-2029058) p-Y151,S,T-WASF1 [cytosol] (R-HSA-5672390)	0.641	3
UniProt:O08816 Wasl	1	N-Wasp [cytosol] (R-RNO-442543)	0.639	4
UniProt:P68135 ACTS			0.623	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	19
UniProt:P07830 ACT1			0.611	3
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.564	2
UniProt:Q13618 CUL3	3	G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516) CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979)	0.527	2