Reactome | TEAD2 [nucleoplasm]

TEAD2 [nucleoplasm]

Stable Identifier

R-HSA-2032763

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcriptional enhancer factor TEF-4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15562 TEAD2

Gene Names

TEAD2, TEF4

Chain

chain:1-447

Reference Genes

BioGPS Gene:8463 TEAD2

COSMIC (genes):TEAD2 TEAD2

CTD Gene:8463 TEAD2

dbSNP Gene:8463 TEAD2

ENSEMBL:ENSG00000074219 TEAD2

HGNC:11715 TEAD2

KEGG:hsa:8463 TEAD2

Monarch:8463 TEAD2

NCBI Gene:8463 TEAD2

OMIM:601729 TEAD2

UCSC:Q15562 TEAD2

Reference Transcript

Participates

as a candidate of

TEAD1,TEAD4,(TEAD2,TEAD3) [nucleoplasm] (Homo sapiens)

as a component of

TEAD2:YAP1 [nucleoplasm] (Homo sapiens)

as an input of

YAP1 binds TEAD2 (Homo sapiens)

as a member of

TEADs [nucleoplasm] (Homo sapiens)

Inferred To

egl-44 [nucleoplasm] (Caenorhabditis elegans)

tead4 [nucleoplasm] (Xenopus tropicalis)

sd [nucleoplasm] (Drosophila melanogaster)

TEAD2 [nucleoplasm] (Bos taurus)

TEAD2 [nucleoplasm] (Canis familiaris)

TEAD2 [nucleoplasm] (Sus scrofa)

TEC1 [nucleoplasm] (Saccharomyces cerevisiae)

Tead2 [nucleoplasm] (Mus musculus)

Tead2 [nucleoplasm] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

3241

OpenTargets

ENSG00000074219

ENSEMBL

ENSP00000472109, ENSP00000310701, ENST00000311227, ENSP00000366419, ENST00000593945, ENSP00000437928, ENSP00000469672, ENSP00000469640, ENST00000539846, ENST00000601519, ENST00000598810, ENSG00000074219, ENST00000377214

HPA

ENSG00000074219-TEAD2

GeneCards

TEAD2

PRO

Q15562

Pharos - Targets

Q15562

PDB

6S69, 6CDY, 6UYB, 6UYC, 5HGU, 8P29, 7TYU, 7T2K, 5EMV, 7TYP, 7T2L, 6S66, 7T2J, 6S60, 7TYQ, 8CUH, 5DQE, 3L15, 7OYJ, 8E1O, 6VAH, 7T2M, 6S64, 8POM, 8PON, 8PUX, 8PUY, 6E5G, 6S6J, 5DQ8, 8POJ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46937 YAP1	8	YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.823	9
UniProt:Q9GZV5 WWTR1	3	WWTR1 [nucleoplasm] (R-HSA-1629775) WWTR1 [cytosol] (R-HSA-1629773) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.643	5
UniProt:Q5TBC7 B2L15			0.61	4
UniProt:Q15853 USF2	1	USF2 [nucleoplasm] (R-HSA-9023564)	0.556	3
UniProt:P28347 TEAD1	1	TEAD1 [nucleoplasm] (R-HSA-2032774)	0.527	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.527	2
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.527	2
UniProt:P0DJI9 SAA2			0.488	2