Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
WWTR1 [cytosol]
Stable Identifier
R-HSA-1629773
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, TAZ
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)
AMOT:WWTR1 (TAZ) [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1:TJP1 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1:TJP2 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
WWTR1:SMAD translocates to the nucleus (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
WWTR1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9GZV5 WWTR1
Gene Names
WWTR1, TAZ
Chain
chain:1-400
Reference Genes
BioGPS Gene:25937 WWTR1
COSMIC (genes):WWTR1 WWTR1
CTD Gene:25937 WWTR1
dbSNP Gene:25937 WWTR1
ENSEMBL:ENSG00000018408.15 WWTR1
HGNC:24042 WWTR1
KEGG Gene (Homo sapiens):25937 WWTR1
Monarch:25937 WWTR1
NCBI Gene:25937 WWTR1
OMIM:607392 WWTR1
UCSC:Q9GZV5 WWTR1
Reference Transcript
RefSeq:NM_001168278.2 WWTR1
RefSeq:NM_001348362.1 WWTR1
RefSeq:XM_017006122.1 WWTR1
RefSeq:NM_001168280.2 WWTR1
RefSeq:NM_015472.5 WWTR1
Other Identifiers
11755099_a_at
11759482_at
11759483_at
202132_PM_at
202132_at
202133_PM_at
202133_at
202134_PM_s_at
202134_s_at
25937
2700407
2700408
2700409
2700410
2700411
2700412
2700413
2700414
2700415
2700417
2700418
2700425
2700433
2700461
2700463
2700464
2700471
33876_at
8091422
A_23_P29769
A_24_P944383
A_24_P944390
A_32_P6868
GE56247
GE82008
GO:0000122
GO:0001649
GO:0001894
GO:0001933
GO:0003013
GO:0003015
GO:0003713
GO:0003714
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006469
GO:0008284
GO:0010718
GO:0016020
GO:0016567
GO:0016604
GO:0017145
GO:0023052
GO:0030154
GO:0030163
GO:0031146
GO:0032835
GO:0032991
GO:0035264
GO:0035329
GO:0036211
GO:0042803
GO:0043226
GO:0044782
GO:0045599
GO:0045669
GO:0045944
GO:0048762
GO:0048856
GO:0060271
GO:0060390
GO:0060828
GO:0060993
GO:0072307
GO:0090090
GO:1900182
HMNXSV003013267
Hs.24341.0.A2_3p_at
Hs.24341.0.A3_3p_at
ILMN_1787115
PH_hs_0002143
g13346497_3p_a_at
Participates
as a component of
AMOT:WWTR1 (TAZ) [cytosol] (Homo sapiens)
WWTR1:TJP2 [cytosol] (Homo sapiens)
WWTR1:TJP1 [cytosol] (Homo sapiens)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Homo sapiens)
as an input of
AMOT proteins bind WWTR1 (TAZ) (Homo sapiens)
Phosphorylation of WWTR1 (TAZ) by LATS2 (Homo sapiens)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Homo sapiens)
WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)
WWTR1 (TAZ) binds ZO-1 (TJP1) (Homo sapiens)
Translocation of WWTR1 (TAZ) to the nucleus (Homo sapiens)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Homo sapiens)
Other forms of this molecule
p-S89-WWTR1 [cytosol]
WWTR1 [nucleoplasm]
Inferred To
WWTR1 [cytosol]
(Bos taurus)
WWTR1 [cytosol]
(Canis familiaris)
WWTR1 [cytosol]
(Danio rerio)
WWTR1 [cytosol]
(Gallus gallus)
WWTR1 [cytosol]
(Sus scrofa)
mblac1 [cytosol]
(Xenopus tropicalis)
yki [cytosol]
(Drosophila melanogaster)
Wwtr1 [cytosol]
(Mus musculus)
Wwtr1 [cytosol]
(Rattus norvegicus)
yap-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001335291.1
,
NP_001161750.1
,
NP_056287.1
,
NP_001161752.1
,
XP_016861611.1
OpenTargets
ENSG00000018408
HPA
ENSG00000018408-WWTR1
GeneCards
Q9GZV5
Ensembl
ENST00000465804
,
ENST00000467467
,
ENSG00000018408
,
ENST00000360632
,
ENSP00000419234
,
ENSP00000353847
,
ENSP00000419465
PRO
Q9GZV5
Pharos - Targets
Q9GZV5
Orphanet
23229
PDB
6SLX
,
5N75
,
5N5R
,
6RP6
,
5N5W
,
6RJQ
,
6SLW
,
6RJL
,
5N5T
,
6RHC
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15561 TEAD4
1
TEAD4 [nucleoplasm]
(R-HSA-2032780)
0.851
9
UniProt:Q99594 TEAD3
1
TEAD3 [nucleoplasm]
(R-HSA-2032767)
0.667
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.659
3
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.641
4
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1097-LATS1 [cytosol]
(R-HSA-2028551)
0.641
5
UniProt:Q969T9 WBP2
0.61
6
UniProt:Q9BZD6 TMG4
0.602
4
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.591
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.59
3
UniProt:P62262 1433E
0.571
3
UniProt:Q9NUJ3 T11L1
0.556
3
UniProt:Q8WWV3 RT4I1
0.556
3
UniProt:Q96LT6 CA074
0.556
3
UniProt:P28347-2 TEAD1
0.556
3
UniProt:Q15562-2 TEAD2
0.556
3
UniProt:Q14005-2 Q140052
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.547
2
UniProt:Q01196 RUNX1
5
RUNX1 [plasma membrane]
(R-HSA-5667138)
p-S249,S273,T276-RUNX1 [nucleoplasm]
(R-HSA-8878063)
MeR206,MeR210-RUNX1 [nucleoplasm]
(R-HSA-8934750)
p-7Y-RUNX1 [nucleoplasm]
(R-HSA-8937712)
RUNX1 [nucleoplasm]
(R-HSA-8865295)
0.527
2
UniProt:Q15562 TEAD2
1
TEAD2 [nucleoplasm]
(R-HSA-2032763)
0.527
2
UniProt:O14640 DVL1
4
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
0.524
2
UniProt:P78371 CCT2
3
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [cytosol]
(R-HSA-390464)
0.499
2
UniProt:Q15599 NHRF2
0.463
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text