Reactome | SUPT16H [nucleoplasm]

SUPT16H [nucleoplasm]

Stable Identifier

R-HSA-112415

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FACT 140 kDa subunit

Locations in the PathwayBrowser

Expand all

General

DSIF is a heterodimer consisting of hSPT4 (human homolog of yeast Spt4- p14) and hSPT5 (human homolog of yeast Spt5-p160). DSIF association with Pol II may be enabled by Spt5 binding to Pol II creating a scaffold for NELF binding (Wada et al.,1998). Spt5 subunit of DSIF can be phosphorylated by P-TEFb.

External Reference Information

External Reference

UniProt:Q9Y5B9 SUPT16H

Gene Names

SUPT16H, FACT140, FACTP140

Chain

initiator methionine:1, chain:2-1047

Reference Genes

BioGPS Gene:11198 SUPT16H

COSMIC (genes):SUPT16H SUPT16H

CTD Gene:11198 SUPT16H

dbSNP Gene:11198 SUPT16H

ENSEMBL:ENSG00000092201 SUPT16H

ENSEMBL:ENSG00000092201.10 SUPT16H

HGNC:11465 SUPT16H

KEGG Gene (Homo sapiens):11198 SUPT16H

Monarch:11198 SUPT16H

NCBI Gene:11198 SUPT16H

OMIM:605012 SUPT16H

UCSC:Q9Y5B9 SUPT16H

Reference Transcript

RefSeq:NM_007192.3 SUPT16H

Other Identifiers

11198

11717114_a_at

16790267

217815_PM_at

217815_at

233827_PM_s_at

233827_s_at

3446084

3446086

3446094

3446097

3446099

3446101

3446103

3446107

3446108

3446109

3556324

3556325

3556326

3556327

3556329

3556330

3556331

3556333

3556334

3556336

3556337

3556338

3556339

3556340

3556341

3556342

3556343

3556344

3556345

3556346

3556347

3556348

3556349

3556350

3556352

3556353

3556354

3556356

3556358

3556364

3556365

3556366

57040_at

68143_at

7977674

90470_r_at

A_23_P151634

A_24_P153800

GE58441

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006281

GO:0006325

GO:0006334

GO:0006337

GO:0006351

GO:0006355

GO:0006366

GO:0006368

GO:0006974

GO:0031491

GO:0032786

GO:0035101

GO:0043226

GO:0065003

HMNXSV003007434

Hs.14963.1.S1_3p_a_at

ILMN_1781516

TC14000916.hg

g6005756_3p_at

Participates

as an input of

Formation of FACT complex (Homo sapiens)

as a component of

FACT complex [nucleoplasm] (Homo sapiens)

Inferred To

spt-16 [nucleoplasm] (Caenorhabditis elegans)

spt16 [nucleoplasm] (Dictyostelium discoideum)

spt16 [nucleoplasm] (Schizosaccharomyces pombe)

supt16h [nucleoplasm] (Xenopus tropicalis)

SUPT16H [nucleoplasm] (Bos taurus)

SUPT16H [nucleoplasm] (Canis familiaris)

SUPT16H [nucleoplasm] (Plasmodium falciparum)

SUPT16H [nucleoplasm] (Sus scrofa)

Ghost homologue of SUPT16H [nucleoplasm] (Gallus gallus)

SPT16 [nucleoplasm] (Saccharomyces cerevisiae)

Supt16h [nucleoplasm] (Mus musculus)

Supt16h [nucleoplasm] (Rattus norvegicus)

dre4 [nucleoplasm] (Drosophila melanogaster)

zgc:194732 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_009123.1

OpenTargets

ENSG00000092201

HPA

ENSG00000092201-SUPT16H

GeneCards

Q9Y5B9

Ensembl

ENSG00000092201, ENST00000216297, ENSP00000216297

PRO

Q9Y5B9

Pharos - Targets

Q9Y5B9

Orphanet

29691

PDB

5UMU, 5XM2, 4Z2M, 8I17, 6UPK, 5UMT, 5E5B, 6UPL, 4Z2N

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.855	7
UniProt:P33991 MCM4	1	MCM4 [nucleoplasm] (R-HSA-68549)	0.602	3
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.569	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.547	2
UniProt:P16104 H2AX	7	K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:Q9UGP5 POLL	1	POLL [nucleoplasm] (R-HSA-5687352)	0.508	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.462	3
UniProt:Q9UPN9 TRIM33	1	TRIM33 [nucleoplasm] (R-HSA-870522)	0.462	3