Reactome | DUSP10 [nucleoplasm]

DUSP10 [nucleoplasm]

Stable Identifier

R-HSA-203793

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dual specificity protein phosphatase 10, DUSA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y6W6 DUSP10

Gene Names

DUSP10, MKP5

Chain

chain:1-482

Reference Genes

BioGPS Gene:11221 DUSP10

COSMIC (genes):DUSP10 DUSP10

CTD Gene:11221 DUSP10

dbSNP Gene:11221 DUSP10

ENSEMBL:ENSG00000143507 DUSP10

HGNC:3065 DUSP10

KEGG:hsa:11221 DUSP10

Monarch:11221 DUSP10

NCBI Gene:11221 DUSP10

OMIM:608867 DUSP10

UCSC:Q9Y6W6 DUSP10

Reference Transcript

RefSeq:NM_007207.5 DUSP10

Other Identifiers

11221

11729169_a_at

11729170_x_at

11731303_a_at

11751237_a_at

16699533

215501_PM_s_at

215501_s_at

221563_PM_at

221563_at

2457260

2457262

2457263

2457264

2457267

2457268

2457273

2457283

2457284

2457285

2457288

2457289

38555_at

56889_at

7924450

A_23_P51856

A_24_P182494

GE53677

GO:0002819

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006470

GO:0008330

GO:0008432

GO:0010633

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0030154

GO:0030336

GO:0032496

GO:0032873

GO:0033549

GO:0033550

GO:0035970

GO:0043226

GO:0043508

GO:0045088

GO:0045591

GO:0046329

GO:0048273

GO:0048709

GO:0048715

GO:0050680

GO:0051403

GO:0060266

GO:0070373

GO:0090335

GO:0140096

GO:1903753

GO:1905042

GO:1990264

HMNXSV003046016

HMNXSV003052620

Hs.177534.0.S2_3p_at

Hs.177534.1.S1_3p_a_at

ILMN_1759175

ILMN_1759488

ILMN_2401873

ILMN_2401878

PH_hs_0010548

TC01003847.hg

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Homo sapiens)

Other forms of this molecule

DUSP10 [cytosol]

Inferred To

mpl2 [nucleoplasm] (Dictyostelium discoideum)

dusp10 [nucleoplasm] (Xenopus tropicalis)

DUSP10 [nucleoplasm] (Bos taurus)

DUSP10 [nucleoplasm] (Canis familiaris)

DUSP10 [nucleoplasm] (Dictyostelium discoideum)

DUSP10 [nucleoplasm] (Gallus gallus)

DUSP10 [nucleoplasm] (Plasmodium falciparum)

DUSP10 [nucleoplasm] (Sus scrofa)

Homologues of DUSP10 [nucleoplasm] (Dictyostelium discoideum)

mpl1 [nucleoplasm] (Dictyostelium discoideum)

Dusp10 [nucleoplasm] (Mus musculus)

Dusp10 [nucleoplasm] (Rattus norvegicus)

mpl3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_009138.1

ENSEMBL

ENSP00000355866, ENST00000366899

OpenTargets

ENSG00000143507

HPA

ENSG00000143507-DUSP10

ZINC - Substances

DUS10_HUMAN

ZINC target

Q9Y6W6

PRO

Q9Y6W6

Pharos - Targets

Q9Y6W6

ZINC - Predictions - Purchasable

DUS10_HUMAN

HMDB Protein

HMDBP08903

PDB

3TG1, 7Y4B, 7UMV, 7Y4D, 7Y4C, 7Y4E, 7U4O, 1ZZW, 6MC1, 2OUC, 2OUD, 7UMU, 7UN4, 7UN0, 7U4R

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.556	3
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	5
UniProt:P60709 ACTB	5	ACTB [plasma membrane] (R-HSA-196016) ACTB [lysosomal membrane] (R-HSA-196160) ACTB [cytosol] (R-HSA-201861) ACTB [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462)	0.527	2
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2