Reactome | ACTA2 [cytosol]

ACTA2 [cytosol]

Stable Identifier

R-HSA-445792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Actin, aortic smooth muscle, ACTA_HUMAN, alpha-SMA, alpha-smooth muscle actin

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-cell junction organization (Homo sapiens)
    - Adherens junctions interactions (Homo sapiens)
      - Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
        
        Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
        
        Regulation of CDH1 Expression and Function (Homo sapiens)
        
        Regulation of CDH1 Function (Homo sapiens)
        
        CDH1 forms homotypic trans-dimers (Homo sapiens)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        Homotypic CDH1 trans-dimer cluster [plasma membrane] (Homo sapiens)
        
        Homotypic CDH1 trans-dimer [plasma membrane] (Homo sapiens)
        
        Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        trans-Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        CDH1-associated CTNNA1 binds F-actin (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        CDH1-associated CTNNA1 binds VCL (Homo sapiens)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
        
        Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
        
        Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
    - DGC complex binds AGRN and HSPG2 (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
    - DGC:laminin complex binds F-actin (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
      - F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62736 ACTA2

Gene Names

ACTA2, ACTSA, ACTVS, GIG46

Chain

initiator methionine:1, chain:2-377, chain:3-377

Reference Genes

BioGPS Gene:59 ACTA2

COSMIC (genes):ACTA2 ACTA2

CTD Gene:59 ACTA2

dbSNP Gene:59 ACTA2

ENSEMBL:ENSG00000107796 ACTA2

HGNC:130 ACTA2

KEGG:hsa:59 ACTA2

Monarch:59 ACTA2

NCBI Gene:59 ACTA2

OMIM:102620 ACTA2

UCSC:P62736 ACTA2

Reference Transcript

Other Identifiers

11722352_s_at

11760186_at

16716350

200974_PM_at

200974_at

243140_PM_at

243140_at

32755_at

3299505

3299506

3299507

3299508

3299513

3299517

3299518

3299519

3299520

3299521

3299522

3299524

3299525

3299526

3299527

3299529

3299530

3299531

3299532

3299533

3299534

3299535

3299536

3299537

3299538

3299539

3299540

3299541

44618_at

70637_at

7934906

A_21_P0000562

A_23_P150053

GE741965

GE84384

GO:0000166

GO:0001725

GO:0003012

GO:0003013

GO:0005515

GO:0005524

GO:0005604

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005929

GO:0006936

GO:0008217

GO:0009615

GO:0010628

GO:0014829

GO:0015629

GO:0016787

GO:0019901

GO:0030027

GO:0030175

GO:0030312

GO:0030485

GO:0031012

GO:0031514

GO:0032991

GO:0043226

GO:0044297

GO:0048856

GO:0061870

GO:0061874

GO:0070062

GO:0070374

GO:0071560

GO:0072051

GO:0072144

GO:0090131

GO:2000491

HMNXSV003015240

HMNXSV003033272

Hs.208641.0.A1_3p_at

ILMN_1671703

PH_hs_0038301

TC10001498.hg

X13839_at

g4501882_3p_s_at

p24840

Participates

as a protein marker of

as an output of

ACTA2 gene expression is stimulated by NOTCH1, NOTCH2 and NOTCH4 (Homo sapiens)

as a member of

ACTA2, ACTG2 [cytosol] (Homo sapiens)

Inferred To

acta2 [cytosol] (Danio rerio)

act-5 [cytosol] (Caenorhabditis elegans)

Arp53D [cytosol] (Drosophila melanogaster)

Acta2 [cytosol] (Mus musculus)

Acta2 [cytosol] (Rattus norvegicus)

ACTA2 [cytosol] (Bos taurus)

ACTA2 [cytosol] (Canis familiaris)

ACTA2 [cytosol] (Gallus gallus)

ACTA2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001393391.1, NP_001307784.1, NP_001393392.1, NP_001604.1, NP_001393393.1, NP_001135417.1

OpenTargets

ENSG00000107796

ENSEMBL

ENST00000224784, ENST00000713599, ENSP00000518893, ENSP00000518895, ENST00000713597, ENSP00000396730, ENSG00000107796, ENSP00000224784, ENSP00000398239, ENST00000458159, ENST00000415557, ENSP00000518898, ENST00000713602

GeneCards

ACTA2

HPA

ENSG00000107796-ACTA2

PRO

P62736

Pharos - Targets

P62736

GlyGen

P62736

Orphanet

ACTA2

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6IBS0 TWF2	1	TWF2 [cytosol] (R-HSA-9663291)	0.643	4
UniProt:Q8WYL5 SSH1			0.643	3
UniProt:P17900 GM2A	3	GM2A(32-193) [extracellular region] (R-HSA-6806181) GM2A(32-193) [azurophil granule lumen] (R-HSA-6799160) GM2A(32-193) [lysosomal lumen] (R-HSA-1605614)	0.589	2
UniProt:Q9BWQ6 YIPF2			0.589	2
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [cytosol] (R-HSA-5679223) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [autophagosome membrane] (R-HSA-5683638)	0.589	2
UniProt:Q8N4U5 T11L2			0.564	2
UniProt:P11684 UTER			0.564	2
UniProt:Q06141 REG3A	3	REG3A(38-175) [extracellular region] (R-HSA-6801352) REG3A(27-37) [extracellular region] (R-HSA-6801783) REG3A(27-175) [extracellular region] (R-HSA-6801803)	0.527	2
UniProt:P04201 MAS1	1	MAS1 [plasma membrane] (R-HSA-9944591)	0.527	2
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.527	2
UniProt:Q9HA38 ZMAT3			0.527	2
UniProt:Q8TC41 RNF217	1	RNF217 [cytosol] (R-HSA-8850896)	0.527	2
UniProt:P43652 AFAM			0.527	2
UniProt:Q562R1 ACTBL			0.527	3
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.527	2
UniProt:Q7Z7G2 CPLX4			0.527	2
UniProt:Q9P2M7 CGN	1	CGN [cell junction] (R-HSA-2134478)	0.527	2
UniProt:Q9UHA7 IL36A	1	IL36A [extracellular region] (R-HSA-8848324)	0.527	2
UniProt:O75167 PHACTR2	2	PHACTR2 [plasma membrane] (R-HSA-8848883) PHACTR2 [platelet alpha granule membrane] (R-HSA-8848893)	0.527	3
UniProt:Q96L46 CAPNS2	2	CAPNS2 [plasma membrane] (R-HSA-8863453) CAPNS2 [cytosol] (R-HSA-8848629)	0.527	2
UniProt:Q8TAL5 CI043			0.527	2
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.527	2
UniProt:Q03188 CENPC	2	CENPC [nucleoplasm] (R-HSA-5633512) CENPC1 [cytosol] (R-HSA-375292)	0.527	3
UniProt:P40123 CAP2	1	CAP2 [cytosol] (R-HSA-428863)	0.527	3
UniProt:Q16643 DBN1	1	DBN1 [cytosol] (R-HSA-9714666)	0.527	3
UniProt:Q8ND90 PNMA1			0.527	2
UniProt:Q5PRF9 SMAG2			0.527	2
UniProt:O14958 CASQ2	1	CASQ2 [sarcoplasmic reticulum membrane] (R-HSA-2855225)	0.527	2
UniProt:Q9Y6W6 DUSP10	2	DUSP10 [nucleoplasm] (R-HSA-203793) DUSP10 [cytosol] (R-HSA-5675334)	0.527	2
UniProt:Q9NYL9 TMOD3	1	TMOD3 [cytosol] (R-HSA-217354)	0.527	3
UniProt:P10828 THRB	3	THRB [nucleoplasm] (R-HSA-446179) monoSUMO1-K50,K146,K443-THRB [nucleoplasm] (R-HSA-4719421) polySUMO3-K50,K146,K443-THRB [nucleoplasm] (R-HSA-4719433)	0.527	2
UniProt:Q9UKJ8 ADAM21	1	ADAM21 [plasma membrane] (R-HSA-1297340)	0.527	2
UniProt:Q3KR16 PLEKHG6	1	PLEKHG6 [cytosol] (R-HSA-9714266)	0.527	2
UniProt:Q0ZGT2 NEXN			0.527	2
UniProt:P02774 GC	3	GC [extracellular region] (R-HSA-209886) GC [lysosomal lumen] (R-HSA-350137) GC [cytosol] (R-HSA-209929)	0.527	3
UniProt:P12724 RNASE3	2	RNASE3 [extracellular region] (R-HSA-6803115) RNASE3 [azurophil granule lumen] (R-HSA-6799158)	0.527	2
UniProt:Q9UDW3 ZMAT5	1	ZMAT5 [nucleoplasm] (R-HSA-6787850)	0.527	2
UniProt:Q8WTR2 DUS19			0.527	2
UniProt:Q8NG41 NPB	2	NPB(25-48) [extracellular region] (R-HSA-374794) NPB(25-53) [extracellular region] (R-HSA-374790)	0.527	2
UniProt:P15498 VAV1	5	VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.527	2
UniProt:Q8NHS9 SPT22			0.527	2
UniProt:Q92187 ST8SIA4	1	ST8SIA4 [Golgi membrane] (R-HSA-422390)	0.527	2

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