Reactome | SIRT2 [cytosol]

SIRT2 [cytosol]

Stable Identifier

R-HSA-2161118

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NAD-dependent deacetylase sirtuin-2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
        
        ANKLE2 is deacetylated by SIRT2 (Homo sapiens)
        
        SIRT2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IXJ6 SIRT2

Gene Names

SIRT2, SIR2L, SIR2L2

Chain

initiator methionine:1, chain:2-389

Reference Genes

BioGPS Gene:22933 SIRT2

COSMIC (genes):SIRT2 SIRT2

CTD Gene:22933 SIRT2

dbSNP Gene:22933 SIRT2

ENSEMBL:ENSG00000068903 SIRT2

HGNC:10886 SIRT2

KEGG:hsa:22933 SIRT2

Monarch:22933 SIRT2

NCBI Gene:22933 SIRT2

OMIM:604480 SIRT2

UCSC:Q8IXJ6 SIRT2

Reference Transcript

Inferred To

sirt2 [cytosol] (Danio rerio)

SIRT2 [cytosol] (Bos taurus)

SIRT2 [cytosol] (Canis familiaris)

SIRT2 [cytosol] (Gallus gallus)

SIRT2 [cytosol] (Sus scrofa)

Sirt2 [cytosol] (Drosophila melanogaster)

Sirt2 [cytosol] (Mus musculus)

Sirt2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_054176250.1, XP_011524956.1, NP_085096.1, XP_047294424.1, XP_054187933.1, XP_054176249.1, XP_006723174.1, XP_011524957.1, NP_001180215.1, XP_054187934.1, NP_036369.2

ZINC - World Drugs

SIR2_HUMAN

Guide to Pharmacology - Targets

2708

OpenTargets

ENSG00000068903

ENSEMBL

ENSP00000489602, ENSG00000068903, ENSP00000488940, ENST00000392081, ENST00000635478, ENST00000249396, ENSP00000375931, ENSG00000283100, ENST00000634533, ENSP00000249396

ZINC - FDA approved

SIR2_HUMAN

ZINC - Substances

SIR2_HUMAN

ZINC - Biogenic

SIR2_HUMAN

ZINC target

Q8IXJ6

PRO

Q8IXJ6

PDB

8QTU, 4Y6Q, 6NR0, 6L65, 7BOT, 5DY5, 5DY4, 8TGP, 6QCN, 5MAR, 5YQO, 1J8F, 4R8M, 4Y6L, 8QT2, 8QT0, 8QT8, 8QT4, 5YQN, 8XE7, 4RMH, 8QT3, 4X3O, 5YQL, 4RMG, 5G4C, 5Y5N, 6L66, 7BOS, 5D7O, 5Y0Z, 5FYQ, 8PY3, 5MAT, 4L3O, 5D7Q, 8QT1, 5D7P, 3ZGO, 4Y6O, 3ZGV, 5YQM, 6L71, 8QOO, 4RMJ, 8OWZ, 6L72, 4RMI, 4X3P

ZINC - Investigational

SIR2_HUMAN

ZINC - Metabolites

SIR2_HUMAN

HPA

ENSG00000068903-SIRT2

GeneCards

SIRT2

Pharos - Targets

Q8IXJ6

ZINC - Predictions - Purchasable

SIR2_HUMAN

HMDB Protein

HMDBP08880

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.576	4
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.576	3
UniProt:P49591 SARS1	1	SARS [cytosol] (R-HSA-379691)	0.564	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.544	2
UniProt:O60729 CDC14B	1	CDC14B [nucleoplasm] (R-HSA-3214897)	0.524	2
UniProt:P11413 G6PD	1	G6PD [cytosol] (R-HSA-70372)	0.524	3
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.463	2
UniProt:P15172 MYOD1	1	MYOD1 [nucleoplasm] (R-HSA-445441)	0.462	2
UniProt:Q9UM11 FZR1	5	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193) p-S151-FZR1 [nucleoplasm] (R-HSA-9929805)	0.462	2

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