Reactome | FZR1 [nucleoplasm]

FZR1 [nucleoplasm]

Stable Identifier

R-HSA-174099

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cdh1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        FZR1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UM11 FZR1

Gene Names

FZR1, CDH1, FYR, FZR, KIAA1242

Chain

chain:1-496

Reference Genes

BioGPS Gene:51343 FZR1

COSMIC (genes):CDH1 CDH1

COSMIC (genes):FZR1 FZR1

CTD Gene:51343 FZR1

dbSNP Gene:51343 FZR1

ENSEMBL:ENSG00000105325 FZR1

HGNC:24824 FZR1

KEGG:hsa:51343 FZR1

Monarch:51343 FZR1

NCBI Gene:51343 FZR1

OMIM:603619 FZR1

UCSC:Q9UM11 FZR1

Reference Transcript

Other Identifiers

11724896_a_at

11724897_a_at

11742066_a_at

16856959

209414_PM_at

209414_at

209415_PM_at

209415_at

209416_3p_s_at

209416_PM_s_at

209416_s_at

211865_PM_s_at

211865_s_at

3816989

3816996

3816997

3816998

3816999

3817000

3817001

3817002

3817005

3817007

3817008

3817009

3817010

3817011

3817012

3817013

3817014

3817015

3817016

3817017

3817018

3817019

3817020

3817021

3817023

3817024

39855_at

41623_s_at

41624_r_at

51343

77105_at

78663_r_at

8024637

A_14_P100190

A_23_P142325

A_23_P142333

A_24_P318836

A_24_P944291

A_33_P3268368

GE62170

GE82097

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005829

GO:0006281

GO:0007095

GO:0007346

GO:0008284

GO:0010997

GO:0016567

GO:0030154

GO:0030163

GO:0031145

GO:0031965

GO:0040020

GO:0043226

GO:0051301

GO:0051445

GO:0051603

GO:0060090

GO:0070306

GO:0070979

GO:0097027

GO:0098772

GO:1904668

GO:1905786

GO:1990756

GO:1990757

GO:2000773

HMNXSV003003015

HMNXSV003030853

Hs.268384.0.S3_3p_at

Hs.268384.0.S3_3p_x_at

Hs.268384.0.S4_3p_at

ILMN_1753207

PH_hs_0028369

TC19000070.hg

g5813826_3p_a_at

g5813826_3p_x_at

g6463684_3p_a_at

Participates

as an input of

as a member of

as a component of

Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

FZR1 [cytosol]

p-FZR1 [nucleoplasm]

p-FZR1 [cytosol]

p-S151-FZR1 [nucleoplasm]

Inferred To

cdh1 [nucleoplasm] (Dictyostelium discoideum)

fzr1a [nucleoplasm] (Danio rerio)

CDH1 [nucleoplasm] (Saccharomyces cerevisiae)

Fzr1 [nucleoplasm] (Mus musculus)

Fzr1 [nucleoplasm] (Rattus norvegicus)

fzr1 [nucleoplasm] (Xenopus tropicalis)

FZR1 [nucleoplasm] (Bos taurus)

FZR1 [nucleoplasm] (Canis familiaris)

FZR1 [nucleoplasm] (Gallus gallus)

FZR1 [nucleoplasm] (Plasmodium falciparum)

FZR1 [nucleoplasm] (Sus scrofa)

fzr [nucleoplasm] (Drosophila melanogaster)

srw1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001129669.1, NP_057347.2, XP_005259630.1, NP_001129670.1

ENSEMBL

ENSP00000378529, ENST00000313639, ENST00000395095, ENST00000652521, ENSG00000105325, ENSP00000410369, ENSP00000498659, ENST00000441788, ENSP00000321800

OpenTargets

ENSG00000105325

HPA

ENSG00000105325-FZR1

GeneCards

FZR1

PRO

Q9UM11

Pharos - Targets

Q9UM11

GlyGen

Q9UM11

PDB

9GAW, 4UI9, 5L9T, 5L9U, 8TAU, 8TAR

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30260 CDC27	2	CDC27 [cytosol] (R-HSA-174073) CDC27 [nucleoplasm] (R-HSA-174175)	0.879	15
UniProt:Q9UJX6 ANAPC2	2	ANAPC2 [cytosol] (R-HSA-174229) ANAPC2 [nucleoplasm] (R-HSA-174141)	0.802	8
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.643	5
UniProt:Q13042 CDC16	2	CDC16 [cytosol] (R-HSA-174156) CDC16 [nucleoplasm] (R-HSA-174049)	0.643	5
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.643	5
UniProt:P31350 RRM2	1	RRM2 [cytosol] (R-HSA-73639)	0.623	7
UniProt:P20794 MAK			0.602	7
UniProt:Q13309 SKP2	3	SKP2 [nucleoplasm] (R-HSA-975554) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [cytosol] (R-HSA-975495)	0.564	4
UniProt:Q8IXJ6-2 SIRT2			0.544	2
UniProt:P40337-1 VHL			0.544	2
UniProt:Q8NHZ8 CDC26	2	CDC26 [cytosol] (R-HSA-174052) CDC26 [nucleoplasm] (R-HSA-174216)	0.527	3
UniProt:Q96DE5 ANAPC16	2	ANAPC16 [cytosol] (R-HSA-6805138) ANAPC16 [nucleoplasm] (R-HSA-6805137)	0.527	3
UniProt:Q9HAW4 CLSPN	5	PolyUb-CLSPN [nucleoplasm] (R-HSA-6783087) CLSPN(1-1072) [nucleoplasm] (R-HSA-351929) CLSPN(1073-1332) [nucleoplasm] (R-HSA-351935) CLSPN [nucleoplasm] (R-HSA-176282) p-T916,S945-CLSPN [nucleoplasm] (R-HSA-176296)	0.524	4
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.524	2
UniProt:Q8VDQ8	1	SIRT2 [cytosol] (R-MMU-2161118)	0.499	2
UniProt:A2A6Q5	2	Cdc27 [nucleoplasm] (R-MMU-174175) Cdc27 [cytosol] (R-MMU-174073)	0.499	2
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.483	3
UniProt:P0DTD8 NS7B			0.482	2
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.462	2