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FZR1 [cytosol]
Stable Identifier
R-HSA-174249
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Cdh1
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
Association of Cdh1 with the APC/C (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Dephosphorylation of phospho-Cdh1 (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
SCF-beta-TrCP mediated degradation of Emi1 (Homo sapiens)
Phosphorylated Emi1 binds the beta-TrCP in the SCF complex (Homo sapiens)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Homo sapiens)
phospho-Emi1:Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-Emi1(Ser 182):Cdc20/Cdh1:complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-Emi1:Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-Emi1(Ser 182):Cdc20/Cdh1:complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
SCF-mediated degradation of Emi1 (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Homo sapiens)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Homo sapiens)
phospho-Emi1:Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-Emi1(Ser 182):Cdc20/Cdh1:complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Ubiquitination of Emi1 by SCF-beta-TrCP (Homo sapiens)
SCF-associated multiubiquitinated Emi1complexes [cytosol] (Homo sapiens)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Homo sapiens)
phospho-Emi1:Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-Emi1(Ser 182):Cdc20/Cdh1:complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
SCF-beta-TrCP:phospho-Emi1 complexes [cytosol] (Homo sapiens)
phospho-Emi1:Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
phospho-Emi1(Ser 145, Ser 149):Cdc20/Cdh1 complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
phospho-Emi1(Ser 182):Cdc20/Cdh1:complexes [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
APC/C E3 ligase complex [cytosol] (Homo sapiens)
Cdc20/Cdh1 [cytosol] (Homo sapiens)
FZR1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UM11 FZR1
Gene Names
FZR1, CDH1, FYR, FZR, KIAA1242
Chain
chain:1-496
Reference Genes
BioGPS Gene:51343 FZR1
COSMIC (genes):CDH1 CDH1
COSMIC (genes):FZR1 FZR1
CTD Gene:51343 FZR1
dbSNP Gene:51343 FZR1
ENSEMBL:ENSG00000105325 FZR1
HGNC:24824 FZR1
KEGG:hsa:51343 FZR1
Monarch:51343 FZR1
NCBI Gene:51343 FZR1
OMIM:603619 FZR1
UCSC:Q9UM11 FZR1
Reference Transcript
RefSeq:NM_001136198.1 FZR1
RefSeq:XM_005259573.4 FZR1
RefSeq:NM_016263.3 FZR1
RefSeq:NM_001136197.1 FZR1
Other Identifiers
11724896_a_at
11724897_a_at
11742066_a_at
16856959
209414_PM_at
209414_at
209415_PM_at
209415_at
209416_3p_s_at
209416_PM_s_at
209416_s_at
211865_PM_s_at
211865_s_at
3816989
3816996
3816997
3816998
3816999
3817000
3817001
3817002
3817005
3817007
3817008
3817009
3817010
3817011
3817012
3817013
3817014
3817015
3817016
3817017
3817018
3817019
3817020
3817021
3817023
3817024
39855_at
41623_s_at
41624_r_at
51343
77105_at
78663_r_at
8024637
A_14_P100190
A_23_P142325
A_23_P142333
A_24_P318836
A_24_P944291
A_33_P3268368
GE62170
GE82097
GO:0005515
GO:0005634
GO:0005654
GO:0005680
GO:0005737
GO:0005829
GO:0006281
GO:0007095
GO:0007346
GO:0008284
GO:0010997
GO:0016567
GO:0030154
GO:0030163
GO:0031145
GO:0031965
GO:0040020
GO:0043226
GO:0051301
GO:0051445
GO:0051603
GO:0060090
GO:0070306
GO:0070979
GO:0097027
GO:0098772
GO:1904668
GO:1905786
GO:1990756
GO:1990757
GO:2000773
HMNXSV003003015
HMNXSV003030853
Hs.268384.0.S3_3p_at
Hs.268384.0.S3_3p_x_at
Hs.268384.0.S4_3p_at
ILMN_1753207
PH_hs_0028369
TC19000070.hg
g5813826_3p_a_at
g5813826_3p_x_at
g6463684_3p_a_at
Participates
as an output of
Dephosphorylation of phospho-Cdh1 (Homo sapiens)
as an input of
Association of Cdh1 with the APC/C (Homo sapiens)
as a component of
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
as a member of
Cdc20/Cdh1 [cytosol] (Homo sapiens)
Other forms of this molecule
FZR1 [nucleoplasm]
p-FZR1 [nucleoplasm]
p-FZR1 [cytosol]
p-S151-FZR1 [nucleoplasm]
Inferred To
CDH1 [cytosol]
(Saccharomyces cerevisiae)
fzr1 [cytosol]
(Xenopus tropicalis)
FZR1 [cytosol]
(Bos taurus)
FZR1 [cytosol]
(Canis familiaris)
FZR1 [cytosol]
(Gallus gallus)
FZR1 [cytosol]
(Plasmodium falciparum)
FZR1 [cytosol]
(Sus scrofa)
cdh1 [cytosol]
(Dictyostelium discoideum)
srw1 [cytosol]
(Schizosaccharomyces pombe)
fzr [cytosol]
(Drosophila melanogaster)
Fzr1 [cytosol]
(Mus musculus)
Fzr1 [cytosol]
(Rattus norvegicus)
fzr1a [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_001129669.1
,
NP_057347.2
,
XP_005259630.1
,
NP_001129670.1
ENSEMBL
ENSP00000378529
,
ENST00000313639
,
ENST00000395095
,
ENST00000652521
,
ENSG00000105325
,
ENSP00000410369
,
ENSP00000498659
,
ENST00000441788
,
ENSP00000321800
OpenTargets
ENSG00000105325
HPA
ENSG00000105325-FZR1
GeneCards
FZR1
PRO
Q9UM11
Pharos - Targets
Q9UM11
GlyGen
Q9UM11
PDB
9GAW
,
4UI9
,
5L9T
,
5L9U
,
8TAU
,
8TAR
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30260 CDC27
2
CDC27 [cytosol]
(R-HSA-174073)
CDC27 [nucleoplasm]
(R-HSA-174175)
0.879
15
UniProt:Q9UJX6 ANAPC2
2
ANAPC2 [cytosol]
(R-HSA-174229)
ANAPC2 [nucleoplasm]
(R-HSA-174141)
0.802
8
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.643
5
UniProt:Q13042 CDC16
2
CDC16 [cytosol]
(R-HSA-174156)
CDC16 [nucleoplasm]
(R-HSA-174049)
0.643
5
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.643
5
UniProt:P31350 RRM2
1
RRM2 [cytosol]
(R-HSA-73639)
0.623
7
UniProt:P20794 MAK
0.602
7
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.564
4
UniProt:Q8IXJ6-2 SIRT2
0.544
2
UniProt:P40337-1 VHL
0.544
2
UniProt:Q8NHZ8 CDC26
2
CDC26 [cytosol]
(R-HSA-174052)
CDC26 [nucleoplasm]
(R-HSA-174216)
0.527
3
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [cytosol]
(R-HSA-6805138)
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
0.527
3
UniProt:Q9HAW4 CLSPN
5
PolyUb-CLSPN [nucleoplasm]
(R-HSA-6783087)
CLSPN(1-1072) [nucleoplasm]
(R-HSA-351929)
CLSPN(1073-1332) [nucleoplasm]
(R-HSA-351935)
CLSPN [nucleoplasm]
(R-HSA-176282)
p-T916,S945-CLSPN [nucleoplasm]
(R-HSA-176296)
0.524
4
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.524
2
UniProt:Q8VDQ8
1
SIRT2 [cytosol]
(R-MMU-2161118)
0.499
2
UniProt:A2A6Q5
2
Cdc27 [nucleoplasm]
(R-MMU-174175)
Cdc27 [cytosol]
(R-MMU-174073)
0.499
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.483
3
UniProt:P0DTD8 NS7B
0.482
2
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.462
2
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