Reactome | p-S722,S792-RPTOR [cytosol]

p-S722,S792-RPTOR [cytosol]

Stable Identifier

R-HSA-3132767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S722,792-RPTOR, Regulatory-associated protein of mTOR, RPTOR_HUMAN, phosphorylated RPTOR

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - MTORC1 dissociates from ULK complex (Homo sapiens)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        p-S722,S792-RPTOR [cytosol] (Homo sapiens)
    - MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        p-S722,S792-RPTOR [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Homo sapiens)
      - MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        p-S722,S792-RPTOR [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MTOR signalling (Homo sapiens)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Homo sapiens)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        p-S722,S792-RPTOR [cytosol] (Homo sapiens)
  - mTORC1-mediated signalling (Homo sapiens)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Homo sapiens)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Homo sapiens)
        
        mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)
        
        p-S722,S792-RPTOR [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N122 RPTOR

Gene Names

RPTOR, KIAA1303, RAPTOR

Chain

chain:1-1335

Reference Genes

BioGPS Gene:57521 RPTOR

COSMIC (genes):RPTOR RPTOR

CTD Gene:57521 RPTOR

dbSNP Gene:57521 RPTOR

ENSEMBL:ENSG00000141564 RPTOR

HGNC:30287 RPTOR

KEGG:hsa:57521 RPTOR

Monarch:57521 RPTOR

NCBI Gene:57521 RPTOR

OMIM:607130 RPTOR

UCSC:Q8N122 RPTOR

Reference Transcript

Other Identifiers

11722496_a_at

11722497_a_at

11722498_s_at

11745456_a_at

11752252_a_at

11760476_at

16838698

225715_PM_at

225715_at

3737489

3737490

3737491

3737500

3737502

3737519

3737520

3737528

3737532

3737534

3737535

3737536

3737537

3737539

3737551

3737552

3737553

3737560

3737563

3737565

3737568

3737578

3737581

3737582

3737583

3737584

3737585

3737586

3737593

3737601

3737602

3737603

3737604

3737608

3737613

3737614

3737615

3737616

3737617

3737618

3737621

3737623

3737624

3737625

3737626

3737627

3737628

56274_at

57521

71664_at

8010512

A_14_P113638

A_14_P117564

A_14_P121236

A_14_P125470

A_23_P384499

GE53894

GO:0001558

GO:0001938

GO:0005515

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0006355

GO:0006974

GO:0008361

GO:0009267

GO:0009410

GO:0010494

GO:0010506

GO:0010507

GO:0010800

GO:0016020

GO:0019901

GO:0030291

GO:0030295

GO:0030307

GO:0030425

GO:0030674

GO:0031267

GO:0031669

GO:0031929

GO:0031931

GO:0032008

GO:0033138

GO:0035176

GO:0038202

GO:0043025

GO:0043226

GO:0044877

GO:0045672

GO:0045821

GO:0045945

GO:0046889

GO:0060090

GO:0071230

GO:0071233

GO:0071333

GO:0071456

GO:0071470

GO:0071889

GO:0098772

GO:0140767

GO:1900087

GO:1901331

GO:1905857

HMNXSV003041280

Hs.20677.0.S1_3p_at

ILMN_1793514

ILMN_1797816

PH_hs_0023108

TC17000921.hg

Participates

as a component of

mTORC1 with p-S722,S792-RPTOR [cytosol] (Homo sapiens)

Other forms of this molecule

RPTOR [cytosol]

RPTOR [nucleoplasm]

Inferred To

phospho-Rptor [cytosol] (Mus musculus)

phospho-Rptor [cytosol] (Rattus norvegicus)

phospho-daf-15 [cytosol] (Caenorhabditis elegans)

phospho-p-S722,S792-RPTOR [cytosol] (Gallus gallus)

phospho-raptor [cytosol] (Dictyostelium discoideum)

phospho-raptor [cytosol] (Drosophila melanogaster)

phospho-RPTOR [cytosol] (Bos taurus)

phospho-RPTOR [cytosol] (Canis familiaris)

phospho-RPTOR [cytosol] (Sus scrofa)

phospho-rptor [cytosol] (Danio rerio)

phospho-rptor [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 722

Coordinate

722

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 792

Coordinate

792

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001156506.1, NP_065812.1

OpenTargets

ENSG00000141564

ENSEMBL

ENSP00000307272, ENST00000570891, ENSP00000442479, ENST00000306801, ENSP00000460136, ENST00000544334

HPA

ENSG00000141564-RPTOR

PRO

Q8N122

Pharos - Targets

Q8N122

GlyGen

Q8N122

HMDB Protein

HMDBP13901

PDB

7UXH, 6SB2, 7PEB, 6U62, 7UX2, 5H64, 6BCU, 8ERA, 7PEA, 7PEC, 7UXC, 6SB0, 7OWG, 6BCX

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13541 EIF4EBP1	2	p-T37,T46-EIF4EBP1 [cytosol] (R-HSA-165685) EIF4EBP1 [cytosol] (R-HSA-72580)	0.711	5
UniProt:Q96B36 AKT1S1	4	AKT1S1 [cytosol] (R-HSA-200155) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) p-T246-AKT1S1 [cytosol] (R-HSA-377124) AKT1S1 [nucleoplasm] (R-HSA-5083637)	0.669	5
UniProt:O43504 LAMTOR5	1	LAMTOR5 [lysosomal membrane] (R-HSA-5655441)	0.643	4
UniProt:Q0VGL1 LAMTOR4	1	LAMTOR4 [lysosomal membrane] (R-HSA-5655432)	0.643	4
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [specific granule membrane] (R-HSA-6799631)	0.527	2
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.527	2
UniProt:Q9UHA4 LAMTOR3	5	LAMTOR3 [lysosomal membrane] (R-HSA-5653581) LAMTOR3 [endosome membrane] (R-HSA-5693294) LAMTOR3 [specific granule membrane] (R-HSA-6800178) LAMTOR3 [plasma membrane] (R-HSA-6806307) LAMTOR3 [tertiary granule membrane] (R-HSA-6800189)	0.527	3
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.499	6
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.499	3
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.499	3
UniProt:P67999	2	phospho-p-T412-RPS6KB1 [cytosol] (R-RNO-165714) RPS6KB1 [cytosol] (R-RNO-165716)	0.499	2