Reactome | Ub-TLE1 [nucleoplasm]

Ub-TLE1 [nucleoplasm]

Stable Identifier

R-HSA-3322369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

ub-TLE1

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External Reference Information

External Reference

UniProt:Q04724 TLE1

Gene Names

TLE1

Chain

chain:1-770

Reference Genes

BioGPS Gene:7088 TLE1

COSMIC (genes):TLE1 TLE1

CTD Gene:7088 TLE1

dbSNP Gene:7088 TLE1

ENSEMBL:ENSG00000196781 TLE1

HGNC:11837 TLE1

KEGG:hsa:7088 TLE1

Monarch:7088 TLE1

NCBI Gene:7088 TLE1

OMIM:600189 TLE1

UCSC:Q04724 TLE1

Reference Transcript

Other Identifiers

11740414_a_at

17095150

203220_PM_s_at

203220_s_at

203221_PM_at

203221_at

203222_PM_s_at

203222_s_at

228284_PM_at

228284_at

3176267

3211580

3211581

3211583

3211585

3211586

3211588

3211590

3211591

3211592

3211596

3211597

3211598

3211599

3211601

3211604

3211605

3211606

3211609

3211610

3211611

3211612

3211613

3211617

3211618

3211619

3211636

3211637

3211639

3211653

3211654

3211655

3211659

3211660

3211662

3211663

3211664

3979574

3979578

41489_at

56754_at

7088

8161919

A_19_P00812259

A_23_P135239

A_33_P3217719

A_33_P3217731

GE58188

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005829

GO:0006355

GO:0007165

GO:0009887

GO:0010628

GO:0016055

GO:0030178

GO:0042802

GO:0043124

GO:0043226

GO:0045892

GO:0060090

GO:0090090

GO:0140110

GO:0140297

GO:1990907

GO:2000811

HMNXSV003008723

HMNXSV003033673

HMNXSV003043281

Hs.28935.0.A1_3p_a_at

Hs.28935.0.A3_3p_at

Hs.28935.1.S1_3p_at

ILMN_1751572

M99435_at

PH_hs_0024679

TC09001258.hg

g4827027_3p_a_at

Participates

as a component of

ub-TLE1 tetramer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

TLE1 [nucleoplasm]

Inferred To

gro [nucleoplasm] (Drosophila melanogaster)

tle1 [nucleoplasm] (Xenopus tropicalis)

TLE1 [nucleoplasm] (Bos taurus)

TLE1 [nucleoplasm] (Canis familiaris)

TLE1 [nucleoplasm] (Gallus gallus)

TLE1 [nucleoplasm] (Sus scrofa)

Tle1 [nucleoplasm] (Mus musculus)

Tle1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001290032.1, NP_001290033.1, NP_005068.2

ENSEMBL

ENST00000376499, ENSP00000365682

OpenTargets

ENSG00000196781

HPA

ENSG00000196781-TLE1

PRO

Q04724

Pharos - Targets

Q04724

GlyGen

Q04724

PDB

4OM2, 2CE9, 2CE8, 4OM3, 5MWJ, 1GXR

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13761 RUNX3	7	PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.593	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.564	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:O95231 VENTX	1	VENTX [nucleoplasm] (R-HSA-8853887)	0.547	2
UniProt:Q9H2X6 HIPK2	3	p-HIPK2 [nucleoplasm] (R-HSA-6799375) HIPK2 [nucleoplasm] (R-HSA-3215222) monoSUMO1-K32-HIPK2 [nucleoplasm] (R-HSA-4090405)	0.544	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.508	4
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.462	10