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PolyUb-K94,K148-RUNX3 [cytosol]
Stable Identifier
R-HSA-8952400
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
PolyUb-K94,K148-RUNX3 [cytosol] (Homo sapiens)
Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)
PolyUb-K94,K148-RUNX3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13761 RUNX3
Gene Names
RUNX3, AML2, CBFA3, PEBP2A3
Chain
chain:1-415
Reference Genes
COSMIC (genes):RUNX3 RUNX3
dbSNP Gene:864 RUNX3
ENSEMBL:ENSG00000020633 RUNX3
Participates
as an output of
Polyubiquitinated RUNX3 translocates to the cytosol (Homo sapiens)
as an input of
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
Other forms of this molecule
PolyUb-RUNX3 [nucleoplasm]
p-Y-RUNX3 [cytosol]
PolyUb-K94,K148-RUNX3 [nucleoplasm]
Ac-K94,K171-RUNX3 [nucleoplasm]
RUNX3 [cytosol]
RUNX3 [nucleoplasm]
Inferred To
Homologues of PolyUb-K94,K148-RUNX3 [cytosol]
(Drosophila melanogaster)
PolyUb-K94,K148-RUNX3 [cytosol]
(Bos taurus)
PolyUb-K94,K148-RUNX3 [cytosol]
(Caenorhabditis elegans)
PolyUb-K94,K148-RUNX3 [cytosol]
(Canis familiaris)
PolyUb-K94,K148-RUNX3 [cytosol]
(Danio rerio)
PolyUb-K94,K148-RUNX3 [cytosol]
(Gallus gallus)
PolyUb-K94,K148-RUNX3 [cytosol]
(Rattus norvegicus)
PolyUb-K94,K148-RUNX3 [cytosol]
(Sus scrofa)
RunxB [cytosol]
(Drosophila melanogaster)
RunxA [cytosol]
(Drosophila melanogaster)
Runx3 [cytosol]
(Mus musculus)
lz [cytosol]
(Drosophila melanogaster)
run [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at 94
Coordinate
94
Modification
polyubiquitin chain [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at 148
Coordinate
148
Modification
polyubiquitin chain [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.656
12
UniProt:Q9NQB0 TCF7L2
4
TCF7L2 K485fs*25 [nucleoplasm]
(R-HSA-5334040)
TCF7L2 R397W [nucleoplasm]
(R-HSA-5339696)
pT201,T212-TCF7L2 [nucleoplasm]
(R-HSA-4411392)
TCF7L2 [nucleoplasm]
(R-HSA-201923)
0.656
14
UniProt:P25440 BRD2
1
BRD2 [nucleoplasm]
(R-HSA-8951979)
0.599
8
UniProt:Q04724 TLE1
2
Ub-TLE1 [nucleoplasm]
(R-HSA-3322369)
TLE1 [nucleoplasm]
(R-HSA-212327)
0.593
3
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.558
9
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.558
7
UniProt:Q9UQL6 HDAC5
1
HDAC5 [nucleoplasm]
(R-HSA-3004533)
0.499
5
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.499
3
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.462
8
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