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PolyUb-RUNX3 [nucleoplasm]
Stable Identifier
R-HSA-8952417
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
SMURFs ubiquitinate RUNX3 (Homo sapiens)
PolyUb-RUNX3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13761 RUNX3
Gene Names
RUNX3, AML2, CBFA3, PEBP2A3
Chain
chain:1-415
Reference Genes
BioGPS Gene:864 RUNX3
COSMIC (genes):RUNX3 RUNX3
CTD Gene:864 RUNX3
dbSNP Gene:864 RUNX3
ENSEMBL:ENSG00000020633 RUNX3
ENSEMBL_homo_sapiens_GENE:ENSG00000020633.19 RUNX3
HGNC:10473 RUNX3
KEGG Gene (Homo sapiens):864 RUNX3
Monarch:864 RUNX3
NCBI Gene:864 RUNX3
OMIM:600210 RUNX3
UCSC:Q13761 RUNX3
Reference Transcript
RefSeq:XM_005246024.4 RUNX3
RefSeq:NM_004350.2 RUNX3
RefSeq:NM_001320672.1 RUNX3
RefSeq:NM_001031680.2 RUNX3
Other Identifiers
106_at
11740486_a_at
11743428_a_at
11752954_x_at
11755054_x_at
16683624
204197_PM_s_at
204197_s_at
204198_PM_s_at
204198_s_at
2401988
2401990
2401992
2401993
2401995
2401996
2401997
2402004
2402008
2402013
2402016
2402017
2402018
2402026
2402027
2402028
2402029
7913805
864
A_23_P51231
A_33_P3221748
GE60398
GE84493
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001222
GO:0001503
GO:0002062
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0007155
GO:0016513
GO:0030097
GO:0030154
GO:0030182
GO:0036211
GO:0043226
GO:0043231
GO:0043371
GO:0043378
GO:0043565
GO:0045595
GO:0045786
GO:0045893
GO:0048856
GO:0048935
GO:0050680
GO:0071559
GO:0140110
GO:1990837
HMNXSV003032604
Hs.170019.0.S1_3p_a_at
Hs.170019.1.S1_3p_a_at
Hs.170019.1.S1_3p_at
Hs.170019.1.S1_3p_x_at
ILMN_1751839
ILMN_1787461
PH_hs_0010147
TC01002370.hg
TC01005339.hg
TC01005340.hg
TC01005341.hg
Z35278_at
g4757917_3p_a_at
Participates
as an output of
SMURFs ubiquitinate RUNX3 (Homo sapiens)
Other forms of this molecule
RUNX3 [nucleoplasm]
RUNX3 [cytosol]
Ac-K94,K171-RUNX3 [nucleoplasm]
PolyUb-K94,K148-RUNX3 [cytosol]
PolyUb-K94,K148-RUNX3 [nucleoplasm]
p-Y-RUNX3 [cytosol]
Inferred To
Runx3 [nucleoplasm]
(Mus musculus)
run [nucleoplasm]
(Drosophila melanogaster)
PolyUb-RUNX3 [nucleoplasm]
(Bos taurus)
PolyUb-RUNX3 [nucleoplasm]
(Caenorhabditis elegans)
PolyUb-RUNX3 [nucleoplasm]
(Canis familiaris)
PolyUb-RUNX3 [nucleoplasm]
(Danio rerio)
PolyUb-RUNX3 [nucleoplasm]
(Gallus gallus)
PolyUb-RUNX3 [nucleoplasm]
(Rattus norvegicus)
PolyUb-RUNX3 [nucleoplasm]
(Sus scrofa)
Homologues of PolyUb-RUNX3 [nucleoplasm]
(Drosophila melanogaster)
RunxB [nucleoplasm]
(Drosophila melanogaster)
lz [nucleoplasm]
(Drosophila melanogaster)
RunxA [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at unknown position
Modification
polyubiquitin chain [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001307601.1
,
NP_004341.1
,
XP_005246081.1
,
NP_001026850.1
OpenTargets
ENSG00000020633
GeneCards
Q13761
HPA
ENSG00000020633-RUNX3
Ensembl
ENST00000399916
,
ENST00000308873
,
ENSP00000308051
,
ENSG00000020633
,
ENST00000338888
,
ENSP00000343477
,
ENSP00000382800
PRO
Q13761
Pharos - Targets
Q13761
PDB
5W69
HMDB Protein
HMDBP14478
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQB0 TCF7L2
4
TCF7L2 K485fs*25 [nucleoplasm]
(R-HSA-5334040)
TCF7L2 R397W [nucleoplasm]
(R-HSA-5339696)
pT201,T212-TCF7L2 [nucleoplasm]
(R-HSA-4411392)
TCF7L2 [nucleoplasm]
(R-HSA-201923)
0.656
14
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.656
12
UniProt:P25440 BRD2
1
BRD2 [nucleoplasm]
(R-HSA-8951979)
0.599
8
UniProt:Q04724 TLE1
2
Ub-TLE1 [nucleoplasm]
(R-HSA-3322369)
TLE1 [nucleoplasm]
(R-HSA-212327)
0.593
3
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.558
9
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.558
7
UniProt:Q9UQL6 HDAC5
1
HDAC5 [nucleoplasm]
(R-HSA-3004533)
0.499
5
UniProt:Q13951 CBFB
1
CBFB [nucleoplasm]
(R-HSA-8865293)
0.499
3
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.462
8
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