Reactome | PRDX3 [mitochondrial matrix]

PRDX3 [mitochondrial matrix]

Stable Identifier

R-HSA-3323081

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Thioredoxin-dependent peroxide reductase, mitochondrial ecNumber1.11.1.15/ecNumber, PRDX3_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - Detoxification of Reactive Oxygen Species (Homo sapiens)
      - PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O (Homo sapiens)
        
        PRDX3,5 [mitochondrial matrix] (Homo sapiens)
        
        PRDX3 dodecamer [mitochondrial matrix] (Homo sapiens)
        
        PRDX3 dimer [mitochondrial matrix] (Homo sapiens)
        
        PRDX3 [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30048 PRDX3

Gene Names

PRDX3, AOP1

Chain

transit peptide:1-61, chain:62-256

Reference Genes

BioGPS Gene:10935 PRDX3

COSMIC (genes):PRDX3 PRDX3

CTD Gene:10935 PRDX3

dbSNP Gene:10935 PRDX3

ENSEMBL:ENSG00000165672 PRDX3

ENSEMBL_homo_sapiens_GENE:ENSG00000165672.7 PRDX3

HGNC:9354 PRDX3

KEGG Gene (Homo sapiens):10935 PRDX3

Monarch:10935 PRDX3

NCBI Gene:10935 PRDX3

OMIM:604769 PRDX3

UCSC:P30048 PRDX3

Reference Transcript

Other Identifiers

10935

11727804_s_at

11754018_a_at

16718922

201619_PM_at

201619_at

2403550

3309384

3309385

3309386

3309387

3309389

3309390

3309394

3309397

3309398

3309399

3309403

3309407

3309408

36631_at

3960815

7936661

A_23_P63751

D49396_at

GE57226

GO:0001893

GO:0003824

GO:0004601

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006979

GO:0007005

GO:0008284

GO:0008379

GO:0008785

GO:0012501

GO:0016209

GO:0016491

GO:0018171

GO:0019901

GO:0022414

GO:0030099

GO:0030154

GO:0031410

GO:0032496

GO:0032991

GO:0033673

GO:0034599

GO:0034614

GO:0036211

GO:0042542

GO:0042744

GO:0042802

GO:0043027

GO:0043066

GO:0043226

GO:0043231

GO:0045454

GO:0048856

GO:0051092

GO:0051881

GO:0051920

GO:0098754

GO:0098772

GO:0098869

GO:0140824

HMNXSV003034686

ILMN_2395969

ILMN_2395974

PH_hs_0040395

TC10001702.hg

g5802973_3p_at

Participates

as a component of

PRDX3 dimer [mitochondrial matrix] (Homo sapiens)

Inferred To

prdx3 [mitochondrial matrix] (Xenopus tropicalis)

Prdx3 [mitochondrial matrix] (Mus musculus)

Prdx3 [mitochondrial matrix] (Rattus norvegicus)

Prx3 [mitochondrial matrix] (Drosophila melanogaster)

PRDX3 [mitochondrial matrix] (Bos taurus)

PRDX3 [mitochondrial matrix] (Gallus gallus)

PRDX3 [mitochondrial matrix] (Sus scrofa)

prdx-3 [mitochondrial matrix] (Caenorhabditis elegans)

cb718 [mitochondrial matrix] (Danio rerio)

Cross References

RefSeq

NP_006784.1, NP_001289201.1

OpenTargets

ENSG00000165672

IntEnz

1.11.1.24

GeneCards

P30048

HPA

ENSG00000165672-PRDX3

Ensembl

ENSP00000298510, ENST00000298510, ENSG00000165672

PRO

P30048

Pharos - Targets

P30048

Orphanet

24825

PDB

5JCG, 5UCX

HMDB Protein

HMDBP03063

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.796	14
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.508	2