Reactome | p-Y191-CD28 [plasma membrane]

p-Y191-CD28 [plasma membrane]

Stable Identifier

R-HSA-388756

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Phosphorylated CD28

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        Phospho CD28 homodimer [plasma membrane] (Homo sapiens)
        
        p-Y191-CD28 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        Phospho CD28 homodimer [plasma membrane] (Homo sapiens)
        
        p-Y191-CD28 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        Phospho CD28 homodimer [plasma membrane] (Homo sapiens)
        
        p-Y191-CD28 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        CD28:PI3K [plasma membrane] (Homo sapiens)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Homo sapiens)
        
        Phospho CD28 homodimer [plasma membrane] (Homo sapiens)
        
        p-Y191-CD28 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10747 CD28

Gene Names

CD28

Chain

signal peptide:1-18, chain:19-220

Reference Genes

BioGPS Gene:940 CD28

COSMIC (genes):CD28 CD28

CTD Gene:940 CD28

dbSNP Gene:940 CD28

ENSEMBL:ENSG00000178562 CD28

HGNC:1653 CD28

KEGG:hsa:940 CD28

Monarch:940 CD28

NCBI Gene:940 CD28

OMIM:186760 CD28

UCSC:P10747 CD28

Reference Transcript

Other Identifiers

11733978_a_at

11733979_at

11733980_a_at

11753854_a_at

11753855_x_at

11754159_a_at

16889807

206545_PM_at

206545_at

211856_PM_x_at

211856_x_at

211861_PM_x_at

211861_x_at

2523802

2523803

2523804

2523805

2523808

2523809

2523810

2523815

2523816

2523817

2523818

2523819

2523820

2523822

2523824

2523826

2523828

2523830

32861_s_at

50048_at

8047677

940

A_23_P91095

A_33_P3259253

GE553109

GE58392

GO:0001772

GO:0001819

GO:0002376

GO:0002863

GO:0005515

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006366

GO:0006955

GO:0006959

GO:0007166

GO:0009897

GO:0009986

GO:0010628

GO:0010629

GO:0015026

GO:0016020

GO:0019901

GO:0030154

GO:0031295

GO:0032733

GO:0032743

GO:0032753

GO:0035739

GO:0042098

GO:0042102

GO:0042110

GO:0042129

GO:0042802

GO:0043066

GO:0043491

GO:0045060

GO:0045066

GO:0045070

GO:0045589

GO:0045727

GO:0045840

GO:0045944

GO:0048304

GO:0050852

GO:0051897

GO:0060089

GO:0097190

GO:0098636

GO:2000563

HMNXSV003047711

ILMN_1822333

M37815_cds1_at

PH_hs_0000263

TC02001199.hg

g5453610_3p_at

g6969512_3p_x_at

g6969516_3p_a_at

Participates

as a component of

Phospho CD28 homodimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

CD28 [plasma membrane]

CD28 [cytosol]

Inferred To

phospho-Cd28 [plasma membrane] (Mus musculus)

phospho-Cd28 [plasma membrane] (Rattus norvegicus)

phospho-CD28 [plasma membrane] (Bos taurus)

phospho-CD28 [plasma membrane] (Canis familiaris)

phospho-CD28 [plasma membrane] (Sus scrofa)

phospho-ctla4 [plasma membrane] (Xenopus tropicalis)

phospho-p-Y191-CD28 [plasma membrane] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 191

Coordinate

191

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001230006.1, NP_001230007.1, NP_006130.1, XP_011510499.1, XP_011510496.1

Guide to Pharmacology - Targets

2863

OpenTargets

ENSG00000178562

ENSEMBL

ENSP00000363605, ENST00000374481, ENSP00000324890, ENST00000458610, ENST00000324106, ENSP00000393648

HPA

ENSG00000178562-CD28

PRO

P10747

Pharos - Targets

P10747

Orphanet

CD28

GlyGen

P10747

PDB

7PPN, 5AUL, 7VU5, 5GJI, 5GJH, 1YJD, 3WA4, 6O8D

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.903	10
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.462	2

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