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ATP2A2 [platelet dense tubular network membrane]
Stable Identifier
R-HSA-427903
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet dense tubular network membrane
Synonyms
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, AT2A2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Reduction of cytosolic Ca++ levels (Homo sapiens)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)
ATP2A1-3 [platelet dense tubular network membrane] (Homo sapiens)
ATP2A2 [platelet dense tubular network membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen (Homo sapiens)
ATP2A1-3 [platelet dense tubular network membrane] (Homo sapiens)
ATP2A2 [platelet dense tubular network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16615 ATP2A2
Gene Names
ATP2A2, ATP2B
Chain
chain:1-1042
Reference Genes
BioGPS Gene:488 ATP2A2
COSMIC (genes):ATP2A2 ATP2A2
CTD Gene:488 ATP2A2
dbSNP Gene:488 ATP2A2
ENSEMBL:ENSG00000174437 ATP2A2
ENSEMBL_homo_sapiens_GENE:ENSG00000174437.18 ATP2A2
HGNC:812 ATP2A2
KEGG Gene (Homo sapiens):488 ATP2A2
Monarch:488 ATP2A2
NCBI Gene:488 ATP2A2
OMIM:108740 ATP2A2
UCSC:P16615 ATP2A2
Reference Transcript
RefSeq:XM_005253888.2 ATP2A2
RefSeq:NM_170665.3 ATP2A2
RefSeq:XM_011538402.2 ATP2A2
RefSeq:NM_001681.3 ATP2A2
Other Identifiers
11718873_a_at
11718874_s_at
11740332_a_at
11754301_a_at
11754302_a_at
11758558_s_at
16756923
209186_PM_at
209186_at
212361_PM_s_at
212361_s_at
212362_PM_at
212362_at
239996_3p_x_at
239996_PM_x_at
239996_x_at
3431484
3431485
3431487
3431488
3431493
3431497
3431503
3431506
3431507
3431511
3431512
3431513
3431515
3431516
3431517
3431518
3431519
3431520
3431522
3431523
3431526
3431527
3431528
3431529
3431530
3431531
3431532
3431533
3431534
3431535
3431536
3431537
3431538
3431539
3431540
39790_at
39791_at
488
7958644
79971_r_at
83506_at
A_14_P112250
A_14_P119331
A_23_P53603
A_24_P141786
A_24_P73290
GE57875
GE86393
GE86414
GO:0000045
GO:0000166
GO:0002026
GO:0003012
GO:0003013
GO:0003723
GO:0003824
GO:0005215
GO:0005388
GO:0005509
GO:0005515
GO:0005524
GO:0005783
GO:0005789
GO:0005886
GO:0006811
GO:0006816
GO:0006874
GO:0006914
GO:0006984
GO:0006996
GO:0007155
GO:0008544
GO:0010460
GO:0010666
GO:0010882
GO:0012501
GO:0014801
GO:0014883
GO:0014898
GO:0016020
GO:0016192
GO:0016240
GO:0016529
GO:0016787
GO:0016887
GO:0019899
GO:0023052
GO:0030154
GO:0031095
GO:0032469
GO:0032470
GO:0033017
GO:0033292
GO:0034220
GO:0034599
GO:0034976
GO:0043226
GO:0044325
GO:0044548
GO:0045822
GO:0046872
GO:0048856
GO:0055065
GO:0055085
GO:0055119
GO:0061024
GO:0070050
GO:0070296
GO:0070588
GO:0086036
GO:0086039
GO:0090534
GO:0097470
GO:0098909
GO:0106222
GO:0140056
GO:0140657
GO:1900121
GO:1903233
GO:1903515
GO:1903779
GO:1990036
GO:1990456
HMNXSV003018967
HMNXSV003030484
Hs.1526.2.S1_3p_at
Hs.1526.2.S2_3p_a_at
Hs.205454.0.A1_3p_at
Hs.205454.0.A1_3p_x_at
ILMN_1655884
ILMN_1687375
ILMN_1815666
M23114_at
PH_hs_0024236
TC12000856.hg
g184100_3p_s_at
Participates
as a member of
ATP2A1-3 [platelet dense tubular network membrane] (Homo sapiens)
Other forms of this molecule
ATP2A2 [endoplasmic reticulum membrane]
Inferred To
sca-1 [platelet dense tubular network membrane]
(Caenorhabditis elegans)
si:dkey-28b4.8 [platelet dense tubular network membrane]
(Danio rerio)
ATP2A2 [platelet dense tubular network membrane]
(Bos taurus)
ATP2A2 [platelet dense tubular network membrane]
(Canis familiaris)
ATP2A2 [platelet dense tubular network membrane]
(Drosophila melanogaster)
ATP2A2 [platelet dense tubular network membrane]
(Gallus gallus)
ATP2A2 [platelet dense tubular network membrane]
(Mus musculus)
ATP2A2 [platelet dense tubular network membrane]
(Plasmodium falciparum)
ATP2A2 [platelet dense tubular network membrane]
(Rattus norvegicus)
ATP2A2 [platelet dense tubular network membrane]
(Sus scrofa)
Cross References
RefSeq
NP_733765.1
,
XP_005253945.1
,
NP_001672.1
,
XP_011536704.1
Guide to Pharmacology - Targets
841
OpenTargets
ENSG00000174437
HPA
ENSG00000174437-ATP2A2
GeneCards
P16615
Ensembl
ENST00000539276
,
ENSP00000440045
,
ENSG00000174437
,
ENST00000308664
,
ENSP00000311186
PRO
P16615
Pharos - Targets
P16615
Orphanet
15324
HMDB Protein
HMDBP01470
PDB
7BT2
,
6LN5
,
7W7T
,
7W7U
,
6LLY
,
7W7V
,
6LN6
,
7E7S
,
5ZTF
,
6LN7
,
6LLE
,
6LN8
,
7W7W
,
6LN9
,
6JJU
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
16
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.643
3
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.643
3
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:P0DTC4 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9694754)
nascent E [endoplasmic reticulum lumen]
(R-COV-9694312)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694305)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694423)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9694465)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9694687)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698420)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698422)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698416)
0.527
2
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.524
3
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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