Reactome | SORBS3 [cytosol]

SORBS3 [cytosol]

Stable Identifier

R-HSA-445805

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Vinexin, VINEX_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)
        
        SORBS3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60504 SORBS3

Gene Names

SORBS3, SCAM1

Chain

initiator methionine:, chain:1-671

Reference Genes

BioGPS Gene:10174 SORBS3

COSMIC (genes):SORBS3 SORBS3

CTD Gene:10174 SORBS3

dbSNP Gene:10174 SORBS3

ENSEMBL:ENSG00000120896 SORBS3

ENSEMBL_homo_sapiens_GENE:ENSG00000120896.14 SORBS3

HGNC:30907 SORBS3

KEGG Gene (Homo sapiens):10174 SORBS3

Monarch:10174 SORBS3

NCBI Gene:10174 SORBS3

OMIM:610795 SORBS3

UCSC:O60504 SORBS3

Reference Transcript

Other Identifiers

10174

11716773_s_at

11734781_a_at

11747575_a_at

11753099_a_at

17066650

207788_PM_s_at

207788_s_at

209253_PM_at

209253_at

3089484

3089487

3089488

3089489

3089490

3089491

3089493

3089495

3089498

3089500

3089501

3089502

3089505

3089506

3089507

3089511

3089512

3089514

3089516

3089517

3089518

3089520

3089521

3089523

3089524

3089528

3089529

3089530

3089531

3089532

35675_at

8145151

A_14_P139103

A_23_P300714

A_33_P3409625

GE54297

GO:0000122

GO:0000165

GO:0005198

GO:0005200

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0006351

GO:0006355

GO:0007010

GO:0007155

GO:0008092

GO:0017166

GO:0023052

GO:0030055

GO:0031589

GO:0043226

GO:0043410

GO:0051495

GO:0051496

GO:0070161

HMNXSV003024722

HMNXSV003027947

ILMN_1717904

ILMN_1789338

ILMN_2261099

PH_hs_0023606

TC08000173.hg

g3004947_3p_at

g5032072_3p_a_at

Participates

as a component of

integrin:cytoskeletal adhesion complex [plasma membrane] (Homo sapiens)

Inferred To

CAP [cytosol] (Drosophila melanogaster)

Ghost homologue of SORBS3 [cytosol] (Gallus gallus)

SORBS3 [cytosol] (Bos taurus)

SORBS3 [cytosol] (Canis familiaris)

SORBS3 [cytosol] (Rattus norvegicus)

SORBS3 [cytosol] (Sus scrofa)

Sorbs3 [cytosol] (Mus musculus)

sorb-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016868434.1, XP_005273428.1, XP_016868435.1, XP_016868433.1, NP_001018003.1, NP_005766.3

OpenTargets

ENSG00000120896

HPA

ENSG00000120896-SORBS3

GeneCards

O60504

Ensembl

ENSG00000120896, ENSP00000429764, ENSP00000240123, ENST00000523965, ENST00000240123

PRO

O60504

Pharos - Targets

O60504

HMDB Protein

HMDBP01932

PDB

2YUP, 2DLM, 2NWM, 2CT3

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.775	6
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.666	4
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q5ST30 VARS2	1	VARS2 [mitochondrial matrix] (R-HSA-379626)	0.556	3
UniProt:Q15561 TEAD4	1	TEAD4 [nucleoplasm] (R-HSA-2032780)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P31751 AKT2	7	p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056) p-T309-AKT2 [cytosol] (R-HSA-202066) AKT2 [cytosol] (R-HSA-49859) AKT2 [plasma membrane] (R-HSA-202053) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:O75771 RAD51D	1	RAD51D [nucleoplasm] (R-HSA-216920)	0.556	3
UniProt:Q9BST9 RTKN	1	RTKN [cytosol] (R-HSA-5666184)	0.508	3

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