Reactome | MARK4 [cytosol]

MARK4 [cytosol]

Stable Identifier

R-HSA-5626653

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MARKL1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96L34 MARK4

Gene Names

MARK4, KIAA1860, MARKL1

Chain

chain:1-752

Reference Genes

BioGPS Gene:57787 MARK4

COSMIC (genes):MARK4 MARK4

CTD Gene:57787 MARK4

dbSNP Gene:57787 MARK4

ENSEMBL:ENSG00000007047 MARK4

ENSEMBL_homo_sapiens_GENE:ENSG00000007047.16 MARK4

HGNC:13538 MARK4

KEGG Gene (Homo sapiens):57787 MARK4

Monarch:57787 MARK4

NCBI Gene:57787 MARK4

OMIM:606495 MARK4

UCSC:Q96L34 MARK4

Reference Transcript

Other Identifiers

11715214_at

16863243

221560_PM_at

221560_at

3836157

3836158

3836162

3836164

3836165

3836166

3836168

3836169

3836170

3836171

3836173

3836174

3836175

3836177

3836178

3836179

3836183

3836184

3836189

3836192

3836193

3836194

3836195

3836196

3836198

3836201

3836202

3836203

3836204

3836205

3836206

3836207

3836214

55065_PM_at

55065_at

57787

8029642

80445_at

A_14_P116842

A_23_P107714

A_33_P3232980

A_33_P3322415

A_33_P3322428

GE61793

GO:0000166

GO:0000226

GO:0000930

GO:0001578

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006468

GO:0007010

GO:0007049

GO:0007399

GO:0008017

GO:0008092

GO:0008093

GO:0012501

GO:0015630

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030030

GO:0030425

GO:0030496

GO:0035556

GO:0036064

GO:0036211

GO:0042995

GO:0043005

GO:0043015

GO:0043068

GO:0043130

GO:0043226

GO:0044782

GO:0045724

GO:0045787

GO:0046605

GO:0048156

GO:0048856

GO:0050321

GO:0051301

GO:0060090

GO:0065003

GO:0106310

GO:0140096

GO:1900227

GO:1904781

HMNXSV003035622

ILMN_1651604

PH_hs_0006557

TC19000644.hg

g13366083_3p_s_at

Participates

as an input of

MARK4 binds ODF2 in the centriole (Homo sapiens)

as a component of

Inferred To

MARK4 [cytosol] (Bos taurus)

MARK4 [cytosol] (Canis familiaris)

MARK4 [cytosol] (Mus musculus)

MARK4 [cytosol] (Rattus norvegicus)

MARK4 [cytosol] (Sus scrofa)

Ghost homologue of MARK4 [cytosol] (Gallus gallus)

Ghost homologue of MARK4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_113605.2, NP_001186796.1

ZINC - World Drugs

MARK4_HUMAN

Guide to Pharmacology - Targets

2100

OpenTargets

ENSG00000007047

ZINC - FDA approved

MARK4_HUMAN

ZINC - Substances

MARK4_HUMAN

ZINC - Biogenic

MARK4_HUMAN

ZINC target

Q96L34

PRO

Q96L34

PDB

5ES1, 8XFL

ZINC - Investigational

MARK4_HUMAN

GeneCards

Q96L34

HPA

ENSG00000007047-MARK4

Ensembl

ENST00000300843, ENSG00000007047, ENSP00000262891, ENSP00000300843, ENST00000262891

Pharos - Targets

Q96L34

ZINC - Predictions - Purchasable

MARK4_HUMAN

HMDB Protein

HMDBP01243

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.723	7
UniProt:P23258 TUBG1	1	TUBG1 [cytosol] (R-HSA-379269)	0.623	4
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q06481-5 APLP2			0.556	3
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.544	2
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	2
UniProt:P27448 MARK3	1	MARK3 [cytosol] (R-HSA-5672591)	0.527	2
UniProt:Q9UL42 PNMA2			0.527	2
UniProt:Q8ND90 PNMA1			0.499	2
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [cytosol] (R-HSA-442630)	0.499	2
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.499	2

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