Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
POLR1A [nucleoplasm]
Stable Identifier
R-HSA-63494
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
DNA-directed RNA polymerase I largest subunit , RNA polymerase I 194 kDa subunit, RPA194
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
Transcription of intergenic spacer of the rRNA gene (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
B-WICH complex positively regulates rRNA expression (Homo sapiens)
B-WICH complex binds rDNA promoter (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
B-WICH recruits histone acetyltransferases (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 (Homo sapiens)
B-WICH:rDNA Promoter:KAT2B:KAT2A:EP300 [nucleoplasm] (Homo sapiens)
B-WICH:rDNA Promoter:SL1:RNA Pol I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Promoter Escape (Homo sapiens)
Elongation of pre-rRNA transcript (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)
RNA Polymerase I Transcription Initiation complex [nucleoplasm] (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
Binding of RRN3 to RNA Polymerase I (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Initiation complex [nucleoplasm] (Homo sapiens)
Active RNA Polymerase I [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Termination (Homo sapiens)
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
POLR1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95602 POLR1A
Gene Names
POLR1A
Chain
chain:1-1720
Reference Genes
BioGPS Gene:25885 POLR1A
COSMIC (genes):POLR1A POLR1A
CTD Gene:25885 POLR1A
dbSNP Gene:25885 POLR1A
ENSEMBL:ENSG00000068654 POLR1A
HGNC:17264 POLR1A
Monarch:25885 POLR1A
NCBI Gene:25885 POLR1A
OMIM:616404 POLR1A
UCSC:O95602 POLR1A
Reference Transcript
RefSeq:NM_015425.4 POLR1A
Other Identifiers
11724544_a_at
11747136_a_at
16899799
16899801
222704_PM_at
222704_at
228515_PM_at
228515_at
235280_PM_at
235280_at
2562585
2562586
2562599
2562601
2562602
2562604
2562606
2562607
2562608
2562609
2562610
2562611
2562612
2562613
2562614
2562615
2562617
2562618
2562619
2562620
2562622
2562623
2562624
2562625
2562626
2562627
2562628
2562629
2562630
2562631
2562633
2562634
2562635
2562636
2562637
2562638
2562639
2562640
2562642
2562644
2562645
2562646
2562648
2562649
2562650
2562651
2562652
2562653
2562654
2562656
2562657
2562658
2562659
2562661
2562663
2562664
2562665
25885
45463_at
46159_at
51233_at
61086_at
8053496
82202_at
87256_at
88378_at
A_23_P28450
A_24_P936911
A_33_P3271480
A_33_P3320533
GE470332
GE58608
GO:0000287
GO:0000428
GO:0001054
GO:0003677
GO:0003682
GO:0003824
GO:0003899
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005736
GO:0006351
GO:0006360
GO:0008270
GO:0016740
GO:0016779
GO:0034062
GO:0043226
GO:0046872
GO:0071667
GO:0140098
GO:1904750
HMNXSV003008883
HMNXSV003020197
HMNXSV003021793
HMNXSV003033487
Hs.26962.0.A1_3p_at
Hs.59475.0.S2_3p_at
Hs.59475.0.S2_3p_x_at
Hs.83427.0.A1_3p_at
ILMN_1780758
PH_hs_0002387
PH_hs_0031105
TC02002050.hg
TC02002051.hg
TC02004383.hg
p25129
Participates
as an input of
Assembly of RNA Polymerase I Holoenzyme (human) (Homo sapiens)
as a component of
RNA Polymerase I Holoenzyme [nucleoplasm] (Homo sapiens)
Inferred To
rpoa-1 [nucleoplasm]
(Caenorhabditis elegans)
polr1a [nucleoplasm]
(Xenopus tropicalis)
POLR1A [nucleoplasm]
(Bos taurus)
POLR1A [nucleoplasm]
(Canis familiaris)
POLR1A [nucleoplasm]
(Dictyostelium discoideum)
POLR1A [nucleoplasm]
(Drosophila melanogaster)
POLR1A [nucleoplasm]
(Gallus gallus)
POLR1A [nucleoplasm]
(Mus musculus)
POLR1A [nucleoplasm]
(Plasmodium falciparum)
POLR1A [nucleoplasm]
(Rattus norvegicus)
POLR1A [nucleoplasm]
(Saccharomyces cerevisiae)
POLR1A [nucleoplasm]
(Schizosaccharomyces pombe)
POLR1A [nucleoplasm]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000068654
ENSEMBL
ENSP00000263857
,
ENST00000263857
HPA
ENSG00000068654-POLR1A
ZINC - Substances
RPA1_HUMAN
ZINC target
O95602
PRO
O95602
Pharos - Targets
O95602
Orphanet
POLR1A
ZINC - Predictions - Purchasable
RPA1_HUMAN
PDB
7VBC
,
7VBB
,
7OB9
,
7VBA
,
7OBA
,
8A43
,
7OBB
HMDB Protein
HMDBP09345
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.837
6
UniProt:Q9H9Y6 POLR1B
1
POLR1B [nucleoplasm]
(R-HSA-63496)
0.744
4
UniProt:O15160 POLR1C
2
POLR1C [cytosol]
(R-HSA-1964454)
POLR1C [nucleoplasm]
(R-HSA-63498)
0.725
5
UniProt:Q3B726 POLR1F
1
TWISTNB [nucleoplasm]
(R-HSA-5419290)
0.643
4
UniProt:P0DPB6 RPAC2
0.643
3
UniProt:P61218 POLR2F
2
POLR2F [cytosol]
(R-HSA-1964441)
POLR2F [nucleoplasm]
(R-HSA-83714)
0.643
6
UniProt:Q9NWS0 PIHD1
0.643
3
UniProt:P04626 ERBB2
20
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 Y772_A775dup [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
0.567
16
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.556
3
UniProt:Q96IM9 DYDC2
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:Q9P1U0 POLR1H
1
ZNRD1 [nucleoplasm]
(R-HSA-5419292)
0.527
2
UniProt:P52434 POLR2H
2
POLR2H [cytosol]
(R-HSA-1964450)
POLR2H [nucleoplasm]
(R-HSA-63523)
0.527
2
UniProt:Q9GZS1 POLR1E
1
POLR1E [nucleoplasm]
(R-HSA-5419294)
0.527
2
UniProt:P62875 POLR2L
2
POLR2L [cytosol]
(R-HSA-1964467)
POLR2L [nucleoplasm]
(R-HSA-83715)
0.527
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.527
3
UniProt:Q9HCN4 GPN1
0.527
2
UniProt:O15446 POLR1G
1
CD3EAP [nucleoplasm]
(R-HSA-5419289)
0.527
2
UniProt:Q9NYV6 RRN3
1
RRN3 [nucleoplasm]
(R-HSA-73714)
0.527
3
UniProt:P53803 POLR2K
2
POLR2K [cytosol]
(R-HSA-1964445)
POLR2K [nucleoplasm]
(R-HSA-63537)
0.527
2
UniProt:Q9H6T3 RPAP3
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text