Reactome | PolyUb-GATA3 [nucleoplasm]

PolyUb-GATA3 [nucleoplasm]

Stable Identifier

R-HSA-6783009

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

GATA3, Trans-acting T-cell-specific transcription factor GATA-3, GATA3_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP21 deubiquitinates GATA3,IL33 (Homo sapiens)
        
        USP21:PolyUb-GATA3,PolyUb-IL33 [nucleoplasm] (Homo sapiens)
        
        PolyUb-GATA3,PolyUb-IL33 [nucleoplasm] (Homo sapiens)
        
        PolyUb-GATA3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23771 GATA3

Gene Names

GATA3

Chain

chain:1-443

Reference Genes

BioGPS Gene:2625 GATA3

COSMIC (genes):GATA3 GATA3

CTD Gene:2625 GATA3

dbSNP Gene:2625 GATA3

ENSEMBL:ENSG00000107485 GATA3

HGNC:4172 GATA3

KEGG:hsa:2625 GATA3

Monarch:2625 GATA3

NCBI Gene:2625 GATA3

OMIM:131320 GATA3

UCSC:P23771 GATA3

Reference Transcript

Other Identifiers

11729222_a_at

11729223_at

11758057_s_at

16702351

209602_PM_s_at

209602_s_at

209603_PM_at

209603_at

209604_PM_s_at

209604_s_at

2625

3234262

3234274

3234276

3234278

3234279

3234281

3234282

3234283

3234284

3234285

3234286

3234291

3234293

3234298

3234299

3234300

3234301

3234302

3234303

3234304

3234336

3234338

40511_at

7926105

A_14_P102218

A_21_P0007046

A_23_P75056

A_33_P3360341

GO:0000122

GO:0000785

GO:0000902

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001223

GO:0001227

GO:0001228

GO:0001701

GO:0001709

GO:0001764

GO:0001775

GO:0001817

GO:0001819

GO:0001822

GO:0001823

GO:0002088

GO:0002376

GO:0002520

GO:0002572

GO:0003180

GO:0003215

GO:0003281

GO:0003677

GO:0003700

GO:0005134

GO:0005515

GO:0005634

GO:0005654

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0006952

GO:0006954

GO:0006959

GO:0007165

GO:0007399

GO:0007411

GO:0008270

GO:0008283

GO:0008285

GO:0008584

GO:0009615

GO:0009653

GO:0009791

GO:0009967

GO:0010467

GO:0010595

GO:0010628

GO:0010629

GO:0010719

GO:0010975

GO:0022414

GO:0030154

GO:0030182

GO:0030217

GO:0030218

GO:0030225

GO:0030856

GO:0031929

GO:0032689

GO:0032703

GO:0032736

GO:0032753

GO:0032754

GO:0033077

GO:0033600

GO:0035162

GO:0035457

GO:0035799

GO:0035898

GO:0042421

GO:0042472

GO:0042802

GO:0043226

GO:0043491

GO:0043523

GO:0043565

GO:0043583

GO:0043627

GO:0045061

GO:0045064

GO:0045087

GO:0045165

GO:0045582

GO:0045597

GO:0045622

GO:0045786

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048469

GO:0048485

GO:0048538

GO:0048568

GO:0048589

GO:0048646

GO:0048731

GO:0048856

GO:0048870

GO:0048872

GO:0050728

GO:0050852

GO:0051216

GO:0051897

GO:0060017

GO:0060037

GO:0060065

GO:0060070

GO:0060231

GO:0060374

GO:0060676

GO:0061629

GO:0070888

GO:0071345

GO:0071353

GO:0071356

GO:0071599

GO:0071773

GO:0071837

GO:0072107

GO:0072178

GO:0072179

GO:0072182

GO:0072197

GO:0072676

GO:0098542

GO:0140110

GO:1902895

GO:1990837

GO:2000114

GO:2000146

GO:2000352

GO:2000553

GO:2000607

GO:2000611

GO:2000679

GO:2000683

GO:2000703

GO:2000734

HMNXSV003018068

HMNXSV003049654

Hs.169946.0.S3_3p_at

ILMN_2406656

PH_hs_0010139

PH_hs_0031971

TC10000070.hg

X55037_s_at

X58072_at

g13111765_3p_a_at

p18077

Participates

as a member of

PolyUb-GATA3,PolyUb-IL33 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

GATA3 [nucleoplasm]

Inferred To

PolyUb-GATA3 [nucleoplasm] (Rattus norvegicus)

GATA3 [nucleoplasm] (Bos taurus)

GATA3 [nucleoplasm] (Canis familiaris)

GATA3 [nucleoplasm] (Sus scrofa)

gata3 [nucleoplasm] (Xenopus tropicalis)

gtaQ [nucleoplasm] (Dictyostelium discoideum)

Homologues of PolyUb-GATA3 [nucleoplasm] (Dictyostelium discoideum)

gtaT [nucleoplasm] (Dictyostelium discoideum)

grn [nucleoplasm] (Drosophila melanogaster)

Gata3 [nucleoplasm] (Mus musculus)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position

Modification

PolyUb [nucleoplasm]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_002042.1, XP_005252500.1, XP_005252499.1, NP_001002295.1

OpenTargets

ENSG00000107485

ENSEMBL

ENSP00000341619, ENST00000379328, ENSP00000368632, ENST00000346208

HPA

ENSG00000107485-GATA3

PRO

P23771

Pharos - Targets

P23771

Orphanet

GATA3

GlyGen

P23771

PDB

4HC9, 4HC7, 4HCA

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.623	4
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.612	20
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.612	18
UniProt:Q9NP62 GCM1			0.61	9
UniProt:Q9UL17 TBX21			0.576	6
UniProt:P25788 PSMA3	2	PSMA3 [cytosol] (R-HSA-68728) PSMA3 [nucleoplasm] (R-HSA-174323)	0.556	3
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:P10276 RARA	3	RARA [nucleoplasm] (R-HSA-446164) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830)	0.532	5
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.527	2
IntAct:EBI-1265559 MYC			0.527	2
UniProt:Q16665 HIF1A	7	HIF1A [nucleoplasm] (R-HSA-1234135) HIF1A [cytosol] (R-HSA-1234102) p-Y565-HIF1A [cytosol] (R-HSA-8857584) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) 2xHP-HIF1A [cytosol] (R-HSA-1234131) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110)	0.524	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.524	7
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.483	2
UniProt:P08651 NFIC	1	NFIC [nucleoplasm] (R-HSA-60138)	0.471	2
UniProt:Q12857 NFIA	1	NFIA [nucleoplasm] (R-HSA-60134)	0.471	2
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.462	4
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.462	4
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.462	4

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