p-6Y-FGFR3 K650T [plasma membrane]

Stable Identifier
R-HSA-2032966
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
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p-6Y-FGFR3 K650T [plasma membrane] icon
p-6Y-FGFR3 K650T [plasma membrane] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
19855393 Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors

Goriely, A, Hansen, RM, Taylor, IB, Olesen, IA, Jacobsen, GK, McGowan, SJ, Pfeifer, SP, McVean, GA, Rajpert-De Meyts, E, Wilkie, AO

Nat Genet 2009
12461689 Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders

van Rhijn, BW, van Tilborg, AA, Lurkin, I, Bonaventure, J, de Vries, A, Thiery, JP, van der Kwast, TH, Zwarthoff, EC, Radvanyi, F

Eur J Hum Genet 2002
11055896 Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype

Bellus, GA, Spector, EB, Speiser, PW, Weaver, CA, Garber, AT, Bryke, CR, Israel, J, Rosengren, SS, Webster, MK, Donoghue, DJ, Francomano, CA

Am J Hum Genet 2000
External Reference Information
External Reference
UniProt:P22607 FGFR3
Gene Names
FGFR3, JTK4
Chain
signal peptide:1-22, chain:23-806
Reference Genes
ENSEMBL:ENSG00000068078 FGFR3
Participates
as a component of
Other forms of this molecule
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
FGFR3 K650T [plasma membrane]
FGFR3 K650N [plasma membrane]
FGFR3 K650M [plasma membrane]
FGFR3 K650Q [plasma membrane]
FGFR3 A391E [plasma membrane]
FGFR3 K650E [plasma membrane]
FGFR3 G380R [plasma membrane]
FGFR3 G382D [plasma membrane]
FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 A391E [plasma membrane]
p-6Y-FGFR3 G382D [plasma membrane]
p-6Y-FGFR3 G380R [plasma membrane]
p-6Y-FGFR3 K650M [plasma membrane]
p-6Y-FGFR3 K650E [plasma membrane]
p-6Y-FGFR3 K650N [plasma membrane]
p-6Y-FGFR3 K650Q [plasma membrane]
pY-FGFR3 [plasma membrane]
p-6Y-FGFR3 R248C [plasma membrane]
p-6Y-FGFR3 805fs*141 [plasma membrane]
p-6Y-FGFR3 Y373C [plasma membrane]
p-4Y-FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
p-4Y-FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
p-4Y-FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
p-4Y-FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
p-6Y-FGFR3 G370C [plasma membrane]
p-6Y-FGFR3 S371C [plasma membrane]
FGFR3 R248C [plasma membrane]
FGFR3 G370C [plasma membrane]
FGFR3 Y373C [plasma membrane]
FGFR3 S371C [plasma membrane]
FGFR3 [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
L-lysine 650 replaced with L-threonine
Coordinate
650
PsiMod
L-threonine residue [MOD:00026]
A protein modification that effectively converts a source amino acid residue to L-threonine.
L-lysine removal [MOD:01642]
A protein modification that effectively removes or replaces an L-lysine.
Disease
Name Identifier Synonyms
hypochondroplasia DOID:0080041
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
bone development disease DOID:0080006
testicular cancer DOID:2998 testicular tumor, testicular tumor (disorder), testis cancer, testis neoplasm, neoplasm of testis (disorder)
Cross References
COSMIC
Mondo
Interactors (55)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P08238 HSP90AB1  6 0.667 4
 UniProt:O95674 CDS2  1 0.659 4
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:P62333 PSMC6  2 0.556 3
 UniProt:O15534 PER1  4 0.556 3
 UniProt:A0AVK6 E2F8  1 0.556 3
 UniProt:Q9NZH6 IL37  6 0.556 3
 UniProt:P01106 MYC  2 0.556 3
 UniProt:Q13352 ITGB3BP  2 0.556 3
 UniProt:P10809 HSPD1  6 0.556 3
 UniProt:P24941 CDK2  5 0.556 3
 UniProt:Q86WV5 TEN1  1 0.556 3
 UniProt:O43504 LAMTOR5  1 0.556 3
 UniProt:Q6N021 TET2  1 0.556 3
 UniProt:Q7Z7J5 DPPA2  1 0.556 3
 UniProt:Q8WUX9 CHMP7  2 0.556 3
 UniProt:Q16621 NFE2  1 0.556 3
 UniProt:Q13573 SNW1  1 0.556 3
 UniProt:Q06547-2 GABPB1  1 0.556 3
 UniProt:Q6NXG1 ESRP1  3 0.556 3
 UniProt:P19388 POLR2E  2 0.556 3
 UniProt:P14618 PKM  4 0.556 3
 UniProt:Q9H147 DNTTIP1  1 0.556 3
 UniProt:Q15814 TBCC  1 0.556 3
 UniProt:Q8N5V2 NGEF  2 0.556 3
 UniProt:Q9UBX5 FBLN5  1 0.556 3
 UniProt:Q9GZQ8 MAP1LC3B  3 0.556 3
 UniProt:Q06323 PSME1  1 0.556 3
 UniProt:P41134 ID1  1 0.556 3
 UniProt:Q99075 HBEGF  8 0.556 3
 UniProt:Q9H2A9 CHST8  1 0.556 3
 UniProt:Q04206 RELA  7 0.556 3
 UniProt:P22692 IGFBP4  5 0.556 3
 UniProt:Q06547-3 GABPB1  1 0.556 3
 UniProt:O14544 SOCS6  1 0.556 3
 UniProt:P17275 JUNB  1 0.556 3
 UniProt:Q9Y2Y0 ARL2BP  2 0.556 3
 UniProt:P55318 FOXA3  1 0.556 3
 UniProt:Q9UJU6 DBNL  7 0.556 3
 UniProt:Q6IAA8 LAMTOR1  5 0.556 3
 UniProt:Q99743 NPAS2  2 0.556 3
 UniProt:P05412 JUN  4 0.556 3
 UniProt:Q9BXU0 TEX12  1 0.556 3
 UniProt:Q12824 SMARCB1  1 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:P38936 CDKN1A  5 0.556 3
 UniProt:O14641 DVL2  5 0.556 3
 UniProt:P22415 USF1  2 0.556 3
 UniProt:Q9BVC3 DSCC1  1 0.556 3
 UniProt:P62244 RPS15A  2 0.556 3
 UniProt:P23771 GATA3  2 0.556 3
 UniProt:Q9UKV8 AGO2  2 0.556 3
 UniProt:Q00994 BEX3  1 0.556 3
 UniProt:Q07869 PPARA  2 0.556 3
 UniProt:Q8N3R9 PALS1  2 0.556 3
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