Reactome | FBL [nucleoplasm]

FBL [nucleoplasm]

Stable Identifier

R-HSA-6790638

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

rRNA 2'-O-methyltransferase fibrillarin ecNumber2.1.1.-/ecNumber, FBRL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P22087 FBL

Gene Names

FBL, FIB1, FLRN

Chain

chain:1-321

Reference Genes

BioGPS Gene:2091 FBL

COSMIC (genes):FBL FBL

CTD Gene:2091 FBL

dbSNP Gene:2091 FBL

ENSEMBL:ENSG00000105202 FBL

HGNC:3599 FBL

Monarch:2091 FBL

NCBI Gene:2091 FBL

OMIM:134795 FBL

UCSC:P22087 FBL

Reference Transcript

RefSeq:NM_001436.3 FBL

Other Identifiers

11756878_a_at

16872267

2091

211623_3p_s_at

211623_PM_s_at

211623_s_at

32843_s_at

3862159

3862160

3862165

3862166

3862168

3862169

3862170

3862171

3862172

3862173

3862174

3862175

3862176

3862177

3862178

3862179

3862180

3862181

3862182

3862183

3862184

3862185

39173_at

8036777

A_23_P78888

A_23_P78892

GE59817

GO:0000494

GO:0001094

GO:0001649

GO:0001650

GO:0001652

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006325

GO:0006338

GO:0006364

GO:0008168

GO:0008649

GO:0015030

GO:0016020

GO:0016074

GO:0016740

GO:0030154

GO:0031167

GO:0031428

GO:0032040

GO:0032259

GO:0042274

GO:0043226

GO:0048254

GO:0051117

GO:0070062

GO:0140096

GO:0140098

GO:0180021

GO:1990259

GO:1990904

HMNXSV003000480

ILMN_1719205

M30448_s_at

PH_hs_0005575

TC19001526.hg

g181154_3p_s_at

Participates

as a component of

Inferred To

FBL [nucleoplasm] (Bos taurus)

FBL [nucleoplasm] (Caenorhabditis elegans)

FBL [nucleoplasm] (Canis familiaris)

FBL [nucleoplasm] (Dictyostelium discoideum)

FBL [nucleoplasm] (Drosophila melanogaster)

FBL [nucleoplasm] (Mus musculus)

FBL [nucleoplasm] (Plasmodium falciparum)

FBL [nucleoplasm] (Rattus norvegicus)

FBL [nucleoplasm] (Schizosaccharomyces pombe)

FBL [nucleoplasm] (Sus scrofa)

Ghost homologue of FBL [nucleoplasm] (Gallus gallus)

NOP1 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000105202

ENSEMBL

ENSP00000221801, ENST00000625241, ENST00000221801, ENSP00000487390

HPA

ENSG00000105202-FBL

PRO

P22087

Pharos - Targets

P22087

GlyGen

P22087

PDB

7SE9, 7SEA, 7SEC, 2IPX, 7SE6, 7SE8, 7MQ8, 7SE7, 7MQ9, 7MQA, 7SEB, 7SED

HMDB Protein

HMDBP01856

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y2X3 NOP58	3	polySUMO2-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570460) monoSUMO1-K467,K497-NOP58 [nucleoplasm] (R-HSA-4570470) NOP58 [nucleoplasm] (R-HSA-4570488)	0.802	9
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.744	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.725	6
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	13
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.574	3
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.564	2
UniProt:Q9H8H0 NOL11	1	NOL11 [nucleoplasm] (R-HSA-6790684)	0.564	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.543	6
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:Q9H2A9 CHST8	1	CHST8 [Golgi membrane] (R-HSA-6786024)	0.527	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.527	2
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.527	2
UniProt:Q9Y4Z2 NEUROG3	1	NEUROG3 [nucleoplasm] (R-HSA-189530)	0.527	3

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