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PolyUb-ARRB2 [cytosol]
Stable Identifier
R-HSA-6783000
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ARRB2, Beta-arrestin-2, ARRB2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
USP33:PolyUb-CCP110,PolyUb-ARRB1,PolyUb-ARRB2 [cytosol] (Homo sapiens)
PolyUb-CCP110, PolyUb-ARRB2,(PolyUb-ARRB1) [cytosol] (Homo sapiens)
PolyUb-ARRB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32121 ARRB2
Gene Names
ARRB2, ARB2, ARR2
Chain
chain:1-409
Reference Genes
BioGPS Gene:409 ARRB2
COSMIC (genes):ARRB2 ARRB2
CTD Gene:409 ARRB2
dbSNP Gene:409 ARRB2
ENSEMBL:ENSG00000141480.18 ARRB2
HGNC:712 ARRB2
KEGG Gene (Homo sapiens):409 ARRB2
Monarch:409 ARRB2
NCBI Gene:409 ARRB2
OMIM:107941 ARRB2
UCSC:P32121 ARRB2
Reference Transcript
RefSeq:NM_001257328.1 ARRB2
RefSeq:NM_001257330.1 ARRB2
RefSeq:NM_001257331.1 ARRB2
RefSeq:NM_199004.1 ARRB2
RefSeq:NM_001330064.1 ARRB2
RefSeq:NM_001257329.1 ARRB2
RefSeq:NM_004313.3 ARRB2
Other Identifiers
11731620_a_at
11749573_a_at
11755952_x_at
16829835
203388_PM_at
203388_at
33283_at
3707096
3707097
3707104
3707106
3707107
3707109
3707111
3707112
3707113
3707115
3707117
3707119
3707120
3707121
3707122
3707125
3707126
409
8003903
957_at
A_14_P104808
A_23_P158829
GO:0001664
GO:0001932
GO:0001933
GO:0001934
GO:0002031
GO:0002032
GO:0002092
GO:0002376
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005905
GO:0006351
GO:0006355
GO:0006366
GO:0006897
GO:0007005
GO:0007165
GO:0007179
GO:0007186
GO:0007212
GO:0007420
GO:0007628
GO:0008277
GO:0009968
GO:0010628
GO:0012501
GO:0014069
GO:0015031
GO:0016020
GO:0016192
GO:0016323
GO:0016567
GO:0019899
GO:0019904
GO:0022414
GO:0023052
GO:0030139
GO:0030154
GO:0030163
GO:0031397
GO:0031410
GO:0031623
GO:0031625
GO:0031691
GO:0031692
GO:0031701
GO:0031702
GO:0031748
GO:0031762
GO:0031826
GO:0031859
GO:0032088
GO:0032226
GO:0032691
GO:0032695
GO:0032715
GO:0032720
GO:0032967
GO:0033138
GO:0034122
GO:0034260
GO:0034392
GO:0036211
GO:0042699
GO:0042802
GO:0043154
GO:0043161
GO:0043197
GO:0043226
GO:0043422
GO:0043524
GO:0044877
GO:0045211
GO:0045953
GO:0048856
GO:0048870
GO:0050731
GO:0050804
GO:0050877
GO:0050965
GO:0051019
GO:0051897
GO:0051898
GO:0051928
GO:0060079
GO:0060326
GO:0070374
GO:0071889
GO:0090201
GO:0098542
GO:0098926
GO:0098978
GO:1904037
GO:1990763
GO:2000573
GO:2000727
HMNXSV003003302
HMNXSV003016080
ILMN_1675866
ILMN_2395711
PH_hs_0025447
TC17000047.hg
g4757779_3p_at
Participates
as a member of
PolyUb-CCP110, PolyUb-ARRB2,(PolyUb-ARRB1) [cytosol] (Homo sapiens)
Other forms of this molecule
ARRB2 [cytosol]
Inferred To
Arrb2 [cytosol]
(Mus musculus)
Arrb2 [cytosol]
(Rattus norvegicus)
arrb2 [cytosol]
(Xenopus tropicalis)
PolyUb-ARRB2 [cytosol]
(Canis familiaris)
krz [cytosol]
(Drosophila melanogaster)
ARRB2 [cytosol]
(Bos taurus)
ARRB2 [cytosol]
(Sus scrofa)
fc14e09 [cytosol]
(Danio rerio)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [cytosol]) at unknown position
Modification
PolyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_004304.1
,
NP_001244258.1
,
NP_001244259.1
,
NP_001316993.1
,
NP_001244260.1
,
NP_001244257.1
,
NP_945355.1
OpenTargets
ENSG00000141480
HPA
ENSG00000141480-ARRB2
GeneCards
P32121
Ensembl
ENSP00000341895
,
ENST00000346341
,
ENSG00000141480
,
ENSP00000403701
,
ENST00000381488
,
ENST00000412477
,
ENSP00000269260
,
ENST00000269260
,
ENSP00000370898
PRO
P32121
Pharos - Targets
P32121
HMDB Protein
HMDBP14520
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.841
9
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.708
5
UniProt:P49407 ARRB1
5
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.669
8
UniProt:Q13428 TCOF
0.641
4
UniProt:Q14978 NOLC1
0.641
5
UniProt:P07550 ADRB2
5
pS-ADRB2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869143)
ADRB2 [endosome membrane]
(R-HSA-6783036)
PolyUb-ADRB2 [endosome membrane]
(R-HSA-6783066)
pS-ADRB2 [plasma membrane]
(R-HSA-8852158)
ADRB2 [plasma membrane]
(R-HSA-390647)
0.608
3
UniProt:O75688 PPM1B
3
PPM1B(2-282)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713477)
PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9713479)
PPM1B [cytosol]
(R-HSA-1169375)
0.604
4
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.577
4
UniProt:Q08499 PDE4D
1
PDE4D [cytosol]
(R-HSA-52389)
0.564
2
UniProt:P22087 FBL
1
FBL [nucleoplasm]
(R-HSA-6790638)
0.564
2
UniProt:Q08499-2 PDE4D
0.564
2
UniProt:P12931 SRC
6
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.564
2
UniProt:Q9Q2G4 Q9Q2G4
0.558
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P06213-1 INSR
0.544
2
UniProt:P32121 ARRB2
2
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
0.527
3
UniProt:P31750 Akt1
10
p-T308,S473-Akt1 [plasma membrane]
(R-MMU-1445123)
p-T308,S473-Akt1 [cytosol]
(R-MMU-162346)
phospho-p-Y315,Y326-AKT1 [cytosol]
(R-MMU-8848757)
phospho-p-T308,S473-AKT1 [plasma membrane]
(R-MMU-199430)
phospho-p-T308-AKT1 [cytosol]
(R-MMU-198634)
AKT1 [cytosol]
(R-MMU-58252)
AKT1 [plasma membrane]
(R-MMU-199416)
phospho-p-S473-AKT1 [plasma membrane]
(R-MMU-377265)
phospho-p-T308,S473-AKT1 [cytosol]
(R-MMU-198356)
phospho-p-T308,S473-AKT1 [nucleoplasm]
(R-MMU-198357)
0.525
3
UniProt:P62158 CALM
0.499
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.499
3
UniProt:P14618 PKM
3
PKM [secretory granule lumen]
(R-HSA-6801401)
PKM [extracellular region]
(R-HSA-6806491)
PKM [ficolin-1-rich granule lumen]
(R-HSA-6801387)
0.499
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.499
3
UniProt:Q15208 STK38
1
STK38 [cytosol]
(R-HSA-9715143)
0.499
3
UniProt:O95218 ZRAB2
0.499
4
UniProt:P25101 EDNRA
1
EDNRA [plasma membrane]
(R-HSA-388549)
0.499
2
UniProt:P06702 S100A9
3
S100A9 [secretory granule lumen]
(R-HSA-6804774)
S100A9 [cytosol]
(R-HSA-9626869)
S100A9 [extracellular region]
(R-HSA-5432857)
0.499
2
UniProt:P35813 PPM1A
2
PPM1A [cytosol]
(R-HSA-380928)
PPM1A [nucleoplasm]
(R-HSA-205813)
0.499
3
UniProt:Q13523 PRPF4B
1
PRPF4B [nucleoplasm]
(R-HSA-9769525)
0.499
3
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.499
4
UniProt:P19338 NCL
1
NCL [nucleoplasm]
(R-HSA-6791213)
0.499
3
UniProt:Q15750 TAB1
6
TAB1(445-504) [cytosol]
(R-HSA-9729691)
TAB1(133-504) [cytosol]
(R-HSA-9729724)
TAB1(1-132) [cytosol]
(R-HSA-9729698)
TAB1(1-444) [cytosol]
(R-HSA-9729751)
TAB1 [endosome membrane]
(R-HSA-450238)
TAB1 [cytosol]
(R-HSA-167923)
0.483
3
UniProt:Q14247 CTTN
2
CTTN [cytosol]
(R-HSA-201894)
p-S113-CTTN [cytosol]
(R-HSA-442842)
0.483
2
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.483
3
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.483
3
UniProt:P35221 CTNNA1
2
CTNNA1 [cytosol]
(R-HSA-191697)
CTNNA1 [plasma membrane]
(R-HSA-191735)
0.483
3
UniProt:Q13233 MAP3K1
2
MAP3K1 [cytosol]
(R-HSA-166866)
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
0.483
2
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