Reactome | PolyUb-ARRB2 [cytosol]

PolyUb-ARRB2 [cytosol]

Stable Identifier

R-HSA-6783000

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ARRB2, Beta-arrestin-2, ARRB2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
        
        USP33:PolyUb-CCP110,PolyUb-ARRB1,PolyUb-ARRB2 [cytosol] (Homo sapiens)
        
        PolyUb-CCP110, PolyUb-ARRB2,(PolyUb-ARRB1) [cytosol] (Homo sapiens)
        
        PolyUb-ARRB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32121 ARRB2

Gene Names

ARRB2, ARB2, ARR2

Chain

chain:1-409

Reference Genes

BioGPS Gene:409 ARRB2

COSMIC (genes):ARRB2 ARRB2

CTD Gene:409 ARRB2

dbSNP Gene:409 ARRB2

ENSEMBL:ENSG00000141480 ARRB2

HGNC:712 ARRB2

KEGG:hsa:409 ARRB2

Monarch:409 ARRB2

NCBI Gene:409 ARRB2

OMIM:107941 ARRB2

UCSC:P32121 ARRB2

Reference Transcript

Other Identifiers

11731620_a_at

11749573_a_at

11755952_x_at

16829835

203388_PM_at

203388_at

33283_at

3707096

3707097

3707103

3707104

3707105

3707106

3707107

3707108

3707109

3707110

3707111

3707112

3707113

3707114

3707115

3707116

3707117

3707118

3707119

3707120

3707121

3707122

3707123

3707125

3707126

409

8003903

957_at

A_14_P104808

A_23_P158829

GE54808

GO:0001664

GO:0001932

GO:0001933

GO:0002029

GO:0002031

GO:0002092

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005905

GO:0006351

GO:0006355

GO:0006366

GO:0007165

GO:0007179

GO:0007212

GO:0007628

GO:0008277

GO:0009968

GO:0010628

GO:0015031

GO:0016192

GO:0016567

GO:0019899

GO:0030139

GO:0030163

GO:0030666

GO:0031397

GO:0031410

GO:0031623

GO:0031625

GO:0031701

GO:0031748

GO:0032088

GO:0032226

GO:0032691

GO:0032695

GO:0032715

GO:0032720

GO:0034122

GO:0043124

GO:0043161

GO:0043226

GO:0043422

GO:0045953

GO:0048870

GO:0050804

GO:0051897

GO:0051898

GO:0060079

GO:0060090

GO:0060326

GO:0070374

GO:0098794

GO:0098926

GO:0098978

GO:2000727

HMNXSV003003302

HMNXSV003016080

ILMN_1675866

ILMN_2395711

PH_hs_0025447

TC17000047.hg

g4757779_3p_at

Participates

as a member of

PolyUb-CCP110, PolyUb-ARRB2,(PolyUb-ARRB1) [cytosol] (Homo sapiens)

Other forms of this molecule

ARRB2 [cytosol]

ARRB2 [endocytic vesicle membrane]

Inferred To

Arrb2 [cytosol] (Mus musculus)

Arrb2 [cytosol] (Rattus norvegicus)

arrb2 [cytosol] (Xenopus tropicalis)

krz [cytosol] (Drosophila melanogaster)

ARRB2 [cytosol] (Bos taurus)

ARRB2 [cytosol] (Canis familiaris)

ARRB2 [cytosol] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_945355.1, NP_004304.1, NP_001244260.1, NP_001244258.1, NP_001316993.1, NP_001244259.1, NP_001244257.1

OpenTargets

ENSG00000141480

ENSEMBL

ENST00000381488, ENST00000269260, ENSP00000269260, ENSP00000341895, ENSP00000370898, ENST00000412477, ENSG00000141480, ENST00000346341, ENSP00000403701

GeneCards

ARRB2

HPA

ENSG00000141480-ARRB2

PRO

P32121

Pharos - Targets

P32121

GlyGen

P32121

HMDB Protein

HMDBP14520

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P45984 MAPK9	3	p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319) p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293) MAPK9 [cytosol] (R-HSA-450355)	0.841	9
UniProt:Q14978 NOLC1			0.757	8
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.744	10
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.708	5
UniProt:Q00610 CLTC	10	CLTC [plasma membrane] (R-HSA-2980668) CLTC [lysosomal membrane] (R-HSA-2980660) CLTC [clathrin-coated endocytic vesicle membrane] (R-HSA-5138450) CLTC [endolysosome membrane] (R-HSA-8870827) CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710853) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710835) CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710854) CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9710852) CLTC [cytosol] (R-HSA-8856820) CLTC [trans-Golgi network membrane] (R-HSA-5333703)	0.676	6
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.669	4
UniProt:Q13428 TCOF			0.641	4
UniProt:P07550 ADRB2	5	ADRB2 [plasma membrane] (R-HSA-390647) pS-ADRB2 [plasma membrane] (R-HSA-8852158) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143)	0.608	3
UniProt:O75688 PPM1B	3	PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713479) PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713477) PPM1B [cytosol] (R-HSA-1169375)	0.604	4
UniProt:P23528 CFL1	3	CFL1 [cytosol] (R-HSA-350751) p-S3-CFL1 [cytosol] (R-HSA-399813) CFL1 [extracellular region] (R-HSA-350747)	0.577	4
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.564	2
UniProt:Q08499-2 PDE4D			0.564	2
UniProt:P22087 FBL	1	FBL [nucleoplasm] (R-HSA-6790638)	0.564	2
UniProt:Q08499 PDE4D	1	PDE4D [cytosol] (R-HSA-52389)	0.564	2
UniProt:Q9Q2G4 Q9Q2G4			0.558	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P06213-1 INSR			0.544	2
UniProt:Q68CQ4 UTP25	1	DIEXF [nucleoplasm] (R-HSA-6790689)	0.527	3
UniProt:Q7Z4V5 HDGR2			0.527	3
UniProt:P36575 ARRC			0.527	2
UniProt:P31750 Akt1	12	phospho-p-T308,S473-AKT1 [nucleoplasm] (R-MMU-198357) phospho-p-T308,S473-AKT1 [cytosol] (R-MMU-198356) phospho-p-S473-AKT1 [plasma membrane] (R-MMU-377265) AKT1 [plasma membrane] (R-MMU-199416) AKT1 [cytosol] (R-MMU-58252) phospho-p-T308-AKT1 [cytosol] (R-MMU-198634) phospho-p-Y315,Y326-AKT1 [cytosol] (R-MMU-8848757) p-T308,S473-Akt1 [cytosol] (R-MMU-162346) phospho-p-T308,S473-AKT1 [plasma membrane] (R-MMU-199430) Akt1 [cytosol] (R-MMU-189709) phospho-p-S473-AKT1 [cytosol] (R-MMU-9841264) p-T308,S473-Akt1 [plasma membrane] (R-MMU-1445123)	0.525	3
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.499	3
UniProt:P06702 S100A9	3	S100A9 [secretory granule lumen] (R-HSA-6804774) S100A9 [cytosol] (R-HSA-9626869) S100A9 [extracellular region] (R-HSA-5432857)	0.499	2
UniProt:P25101 EDNRA	1	EDNRA [plasma membrane] (R-HSA-388549)	0.499	2
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.499	3
UniProt:O95218 ZRAB2			0.499	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.499	3
UniProt:P14618 PKM	3	PKM [ficolin-1-rich granule lumen] (R-HSA-6801387) PKM [extracellular region] (R-HSA-6806491) PKM [secretory granule lumen] (R-HSA-6801401)	0.499	4
UniProt:P35813 PPM1A	2	PPM1A [nucleoplasm] (R-HSA-205813) PPM1A [cytosol] (R-HSA-380928)	0.499	3
UniProt:P11142 HSPA8	10	HSPA8 [cytosol] (R-HSA-264476) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)	0.499	4
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN [extracellular region] (R-HSA-6806510) GSN [secretory granule lumen] (R-HSA-6801486) GSN(200-270) [extracellular region] (R-HSA-976940)	0.499	3
UniProt:P62158 CALM			0.499	3
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.499	3
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.483	3
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.483	3
UniProt:Q14247 CTTN	2	CTTN [cytosol] (R-HSA-201894) p-S113-CTTN [cytosol] (R-HSA-442842)	0.483	2
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.483	3
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.483	2
UniProt:P35221 CTNNA1	2	CTNNA1 [plasma membrane] (R-HSA-191735) CTNNA1 [cytosol] (R-HSA-191697)	0.483	3

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