Reactome | FTH1 [ficolin-1-rich granule lumen]

FTH1 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6801531

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

Ferritin heavy chain, FRIH_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02794 FTH1

Gene Names

FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15

Chain

chain:1-183, initiator methionine:, chain:2-183

Reference Genes

BioGPS Gene:2495 FTH1

COSMIC (genes):FTH1 FTH1

CTD Gene:2495 FTH1

dbSNP Gene:2495 FTH1

ENSEMBL:ENSG00000167996 FTH1

HGNC:3976 FTH1

KEGG:hsa:2495 FTH1

Monarch:2495 FTH1

NCBI Gene:2495 FTH1

OMIM:134770 FTH1

UCSC:P02794 FTH1

Reference Transcript

RefSeq:NM_002032.2 FTH1

Other Identifiers

11752577_at

11757633_x_at

16739208

200748_3p_s_at

200748_PM_s_at

200748_s_at

214211_PM_at

214211_at

2384397

2495

2545844

2545846

2590361

2590364

2629711

2850328

2956776

3142410

31697_s_at

3375647

3375649

3375650

3375651

3375652

3375653

3375654

3375655

3375656

3375657

3375658

3375662

3375663

3375664

3375665

3375666

33943_at

3505170

3994182

7948656

8170360

A_21_P0013796

A_24_P919330

GE63127

GE81103

GO:0002376

GO:0003824

GO:0004322

GO:0005506

GO:0005515

GO:0005576

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005776

GO:0005829

GO:0006826

GO:0006879

GO:0006880

GO:0006955

GO:0008198

GO:0008199

GO:0008285

GO:0016020

GO:0016491

GO:0031410

GO:0042802

GO:0043226

GO:0044754

GO:0046872

GO:0048147

GO:0070062

GO:0070288

GO:0110076

GO:0140313

GO:0140315

GO:1904724

GO:1904813

HMNXSV003058212

Hs.62954.5.A1_3p_x_at

ILMN_1683146

L20941_at

TC11001860.hg

TC11003179.hg

g4503794_3p_s_at

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

FTH1 [cytosol]

FTH1 [tertiary granule lumen]

FTH1 [extracellular region]

FTH1 [endocytic vesicle lumen]

Inferred To

FTH1 [ficolin-1-rich granule lumen] (Bos taurus)

FTH1 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

FTH1 [ficolin-1-rich granule lumen] (Canis familiaris)

FTH1 [ficolin-1-rich granule lumen] (Gallus gallus)

FTH1 [ficolin-1-rich granule lumen] (Mus musculus)

FTH1 [ficolin-1-rich granule lumen] (Rattus norvegicus)

FTH1 [ficolin-1-rich granule lumen] (Sus scrofa)

Fer2LCH [ficolin-1-rich granule lumen] (Drosophila melanogaster)

ftmt [ficolin-1-rich granule lumen] (Xenopus tropicalis)

LOC119865338 [ficolin-1-rich granule lumen] (Canis familiaris)

Fer3HCH [ficolin-1-rich granule lumen] (Drosophila melanogaster)

Fth1-ps5 [ficolin-1-rich granule lumen] (Rattus norvegicus)

Homologues of FTH1 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

Homologues of FTH1 [ficolin-1-rich granule lumen] (Canis familiaris)

Homologues of FTH1 [ficolin-1-rich granule lumen] (Drosophila melanogaster)

Homologues of FTH1 [ficolin-1-rich granule lumen] (Rattus norvegicus)

Fer1HCH [ficolin-1-rich granule lumen] (Drosophila melanogaster)

fth1a [ficolin-1-rich granule lumen] (Danio rerio)

Cross References

RefSeq

NP_002023.2

OpenTargets

ENSG00000167996

ENSEMBL

ENSP00000273550, ENST00000620041, ENSP00000484477

HPA

ENSG00000167996-FTH1

PRO

P02794

Pharos - Targets

P02794

Orphanet

FTH1

GlyGen

P02794

HMDB Protein

HMDBP08672

PDB

8J9L, 8PP5, 5YI5, 4YKH, 6IPO, 7R5O, 7JGP, 7PF1, 8PP2, 5UP7, 6WYH, 8CPM, 5JKM, 7RRP, 2CN6, 6WYG, 5N26, 8A5N, 8CPX, 3AJQ, 6J4A, 2CHI, 6Z9F, 6GSR, 2Z6M, 5ZND, 8F4L, 3AJO, 5CMR, 4ZJK, 8KFD, 6Z6U, 8DHX, 8PP3, 7ZG7, 7VD8, 6JOB, 6JPS, 7K3V, 6B8G, 6KE4, 5N27, 6M54, 8CPU, 4DYX, 8B7O, 8CPS, 6H5I, 7JGN, 7A6B, 6Z9E, 7JGL, 5XB1, 6H6U, 7K26, 5CMQ, 8J9M, 6IPQ, 7JGQ, 8AAV, 4Y08, 7JGM, 8F49, 8JAI, 5UP9, 5JKL, 4DYY, 6B8F, 8A2L, 8QU9, 8CPT, 7KE5, 6WYF, 2CN7, 6FTV, 4OYN, 5GOU, 6IPC, 2IU2, 2CLU, 3AJP, 1FHA, 7CK8, 6H6T, 8A2M, 7CK9, 7JGK, 8DNP, 7K3W, 6J7G, 7V66, 6IPP, 8HHS, 2CEI, 5UP8, 4DYZ, 4DZ0, 5GN8, 5JKK, 2CIH, 6KE2, 2FHA, 7KE3, 8CPW, 6M52, 8CPV, 5VTD, 7JGO, 7A6A, 3ES3, 3ERZ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.691	5
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.635	3
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.601	4
UniProt:P07476 IVL	2	IVL [cornified envelope] (R-HSA-8847720) IVL [cytosol] (R-HSA-6810837)	0.527	2
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.527	2
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.527	2
UniProt:P02753 RBP4	3	RBP4(19-201) [extracellular region] (R-HSA-2453675) RBP4 I41N [extracellular region] (R-HSA-2471954) RBP4 G75D [extracellular region] (R-HSA-2471928)	0.527	2
UniProt:P20930 FLG	2	FLG(?-?) [cytosol] (R-HSA-6810859) FLG(1-4061) [cytosol] (R-HSA-8849818)	0.527	2
UniProt:P42357 HAL	1	HAL [cytosol] (R-HSA-70897)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2

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