Reactome | TPI1 [cytosol]

TPI1 [cytosol]

Stable Identifier

R-HSA-70451

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

triosephosphate isomerase monomer, TPIS_HUMAN, Triosephosphate isomerase , TIM

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60174 TPI1

Gene Names

TPI1, TPI

Chain

initiator methionine:1, chain:2-249

Reference Genes

BioGPS Gene:7167 TPI1

COSMIC (genes):TPI1 TPI1

CTD Gene:7167 TPI1

dbSNP Gene:7167 TPI1

ENSEMBL:ENSG00000111669 TPI1

ENSEMBL:ENSG00000111669.15 TPI1

HGNC:12009 TPI1

KEGG Gene (Homo sapiens):7167 TPI1

Monarch:7167 TPI1

NCBI Gene:7167 TPI1

OMIM:190450 TPI1

UCSC:P60174 TPI1

Reference Transcript

Other Identifiers

11732392_x_at

11753401_x_at

11754053_x_at

16747529

200822_PM_x_at

200822_x_at

210050_PM_at

210050_at

213011_PM_s_at

213011_s_at

2342882

2342884

2342885

3023287

34003_at

3402936

3402937

3402938

3402939

3402940

3402942

3402943

3402944

3402945

3402947

3402950

3402951

3402952

3402953

3402954

3402955

3402956

3402957

3402959

3402961

7167

7953508

8180371

A_14_P109695

A_23_P53546

GE79869

GO:0003824

GO:0004807

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005829

GO:0005975

GO:0006006

GO:0006091

GO:0006094

GO:0006096

GO:0008929

GO:0016829

GO:0016853

GO:0019242

GO:0019563

GO:0019682

GO:0031625

GO:0042803

GO:0043226

GO:0046166

GO:0055086

GO:0061621

GO:0070062

GO:1901135

HMNXSV003009011

ILMN_1707627

ILMN_2181191

TC12000096.hg

TC12002207.hg

g339840_3p_at

g4507644_3p_a_at

Participates

as a component of

TPI1 dimer [cytosol] (Homo sapiens)

Inferred To

Homologues of TPI1 [cytosol] (Rattus norvegicus)

LOC500959 [cytosol] (Rattus norvegicus)

TPI1 [cytosol] (Bos taurus)

TPI1 [cytosol] (Caenorhabditis elegans)

TPI1 [cytosol] (Canis familiaris)

TPI1 [cytosol] (Danio rerio)

TPI1 [cytosol] (Dictyostelium discoideum)

TPI1 [cytosol] (Drosophila melanogaster)

TPI1 [cytosol] (Gallus gallus)

TPI1 [cytosol] (Mus musculus)

TPI1 [cytosol] (Plasmodium falciparum)

TPI1 [cytosol] (Rattus norvegicus)

TPI1 [cytosol] (Saccharomyces cerevisiae)

TPI1 [cytosol] (Schizosaccharomyces pombe)

TPI1 [cytosol] (Sus scrofa)

TPI1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000356.1, NP_001152759.1, NP_001244955.1

OpenTargets

ENSG00000111669

ZINC - Substances

TPIS_HUMAN

ZINC target

P60174

PRO

P60174

PDB

2IAN, 1WYI, 4UNK, 1HTI, 7SX1, 2VOM, 4ZVJ, 6UP1, 4UNL, 4POC, 4POD, 6D43, 6UP5, 1KLG, 6NLH, 7T0Q, 2JK2, 6C2G, 4E41, 7RDE, 6UP8, 1KLU, 6UPF, 4BR1, 2IAM

IntEnz

5.3.1.1

HPA

ENSG00000111669-TPI1

GeneCards

P60174

Ensembl

ENST00000229270, ENSP00000443599, ENSP00000484435, ENST00000396705, ENSG00000111669, ENSP00000379933, ENST00000613953, ENST00000488464, ENST00000535434, ENSP00000475620, ENSP00000229270

Pharos - Targets

P60174

Orphanet

15646

ZINC - Predictions - Purchasable

TPIS_HUMAN

HMDB Protein

HMDBP01584

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.544	2

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